- Fuyuhiko Tamanoi, University of California, Los Angeles, USA
- David Sigman, University of California School of Medicine, Los Angeles, California, U.S.A.
This is the first compilation of protein lipidation enzymes. This volume summarizes recent dramatic developments regarding enzymes responsible for protein lipidation, a process critical for a number of physiological functions, including cell proliferation and morphology. Inhibitors of protein lipidation have recently been shown to be useful as anticancer drugs. Enzymatic mechanisms, mutational analysis, and structural studies are presented.View full description
Biochemists, molecular biologists, biotechnologists, researchers in biomedical and in pharmaceutical research, physiologists.
- Published: October 2000
- Imprint: ACADEMIC PRESS
- ISBN: 978-0-12-122722-7
Table of ContentsPreface.Mechanism of Catalysis by Protein Farnesyltransferase, R.A. Spence and P.J. Casey.Structure of Protein Farnesyltransferase, K.L. Terry, S.B. Long, and L.S. Beese.Mutational Analyses of Protein Farnesyltransferase, J. Urano, W. Yang, and F. Tamanoi.Farnesyltransferase Inhibitors, J.B. Gibbs.Protein Geranylgeranyltransferase Type I, K. Yokoyama and M.H. Geleb.Biochemistry of Rab Geranylgeranyltransferase, M.C. Seabra.Postisoprenylation Protein Processing: CXXX (CaaX) Endoproteases and Isoprenylcysteine Carboxyl Methyltransferase, S.G. Young, P. Ambroziak, E. Kim, and S. Clarke.Reversible Modification of Proteins with Thioester-Linked Fatty Acids, M.E. Linder.Biology and Enzymology of Protein N-Myristoylation, R.S. Bhatnagar, K. Ashrafi, K. Futterer, G. Waksman, and J.I. Gordon.Chapter References.Author Index.Subject Index.