Principles of Nucleic Acid Structure


  • Stephen Neidle, The School of Pharmacy, University College London, UK

This unique and practical resource provides the most complete and concise summary of underlying principles and approaches to studying nucleic acid structure, including discussion of x-ray crystallography, NMR, molecular modelling, and databases. Its focus is on a survey of structures especially important for biomedical research and pharmacological applications. To aid novices, the book includes an introduction to technical lingo used to describe nucleic acid structure and conformations (roll, slide, twist, buckle, etc.). This completely updated edition features expanded coverage of the latest advances relevant to recognition of DNA and RNA by small molecules and proteins. In particular, the reader will find extensive new discussions on: RNA folding, ribosome structure and antibiotic interactions, DNA quadruplexes, DNA and RNA protein complexes, and short interfering RNA (siRNA). This handy guide ends with a complete list of resources, including relevant online databases and software.
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Researchers in biochemistry, as well as for advanced undergraduate and graduate students studying nucleic acid structure and function.


Book information

  • Published: October 2007
  • ISBN: 978-0-12-369507-9


Review of the previous edition: "Stephen Neidle's excellent new introductory textbook will prove to be very timely, and provides a calm, balanced and objective study of the major advances."--Crystallography News

Table of Contents

Methods for Studying Nucleic Acid Structure.The building-blocks of DNA and RNA.DNA Structure as Observed in Fibres and Crystals.DNA-DNA recognition: non-standard and higher-order DNA structures.Principles of small molecule-DNA Recognition.The RNA structural world.Principles of Protein-DNA Recognition.