Principles of Cellular Engineering

Understanding the Biomolecular Interface

Edited by

  • Michael King, Cornell University, Ithaca, NY, USA

This comprehensive work discusses novel biomolecular surfaces that have been engineered to either control or measure cell function at the atomic, molecular, and cellular levels. Each chapter presents real results, concepts, and expert perspectives of how cells interact with biomolecular surfaces, with particular emphasis on interactions within complex mechanical environments such as in the cardiovascular system. In addition, the book provides detailed coverage of inflammation and cellular immune response as a useful model for how engineering concepts and tools may be effectively applied to complex systems in biomedicine.
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Biomedical engineers, cell and molecular biologists, and graduate students in cell and tissue engineering


Book information

  • Published: December 2005
  • ISBN: 978-0-12-369392-1

Table of Contents

Partial Contents:PART I. NEUTROPHIL ADHESIONAdhesion of flowing neutrophils to model vessel surfacesBond formation during cell compressionA flow chamber for capillary networksMembrane dynamics during neutrophil recruitmentHydrodynamic recruitment of cells to reactive surfacesPART II: CELL-SUBSTRATE ADHESIONCell tensegrity models and cell-substrate interactionsUse of hydrodynamic shear stress to analyze cell adhesionTraction forces exerted by endothelial cellsControl of endothelial cell adhesion by mechanotransmissionPART III. ENGINEERED BIOMIMETIC SURFACESRealistic atomistic modeling of protein adsorption to ceramic biomaterialsCell responses to micro- and nano-topography