Principles and Practice


  • Miles Hacker, The University of Toledo College of Pharmacy, Ohio, USA
  • William Messer, The University of Toledo College of Pharmacy, Ohio, USA
  • Kenneth Bachmann, The University of Toledo College of Pharmacy, Ohio, USA

This unique and much needed textbook meets the rapidly emerging needs of programs training pharmacologic scientists seeking careers in basic research and drug discovery rather than such applied fields as pharmacy and medicine. While the market is crowded with many clinical and therapeutic pharmacology textbooks, the field of pharmacology is booming with the prospects of discovering new drugs, and virtually no extant textbook meets this need at the student level. The market is so bereft of such approaches that many pharmaceutical companies will adopt Hacker, et al. to help train new drug researchers.

The boom in pharmacology is driven by the recent decryption of the human genome and enormous progress in controlling genes and synthesizing proteins, making new and even custom drug design possible. This book makes use of these discoveries in presenting its topics, moving logically from drug receptors to the target molecules drug researchers seek, covering such modern topics along the way as side effects, drug resistance, Pharmacogenomics, and even nutriceuticals, one in a string of culminating chapters on the drug discovery process.
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Advanced undergraduates and beginning graduate students in medical, pharmacy, and graduate schools who want a solid introduction to the basic science of pharmacology and envision careers in drug research


Book information

  • Published: August 2009
  • ISBN: 978-0-12-369521-5

Table of Contents

TABLE OF CONTENTS:1. Routes of Administration2. Membranes and Drug Action3. Drug Absorption4. Drug Transporters in ADME5. Drug Distribution6. Drug Metabolism7. Drug Excretion8. Pharmacokinetics9. Receptor-ligand Interaction10. Molecular Targets for Drug Actions11. Cell Signaling Pathways12. Immunopharmacology13. Drug Toxicity14. Adverse Drug Reactions15. Cell Death16. Pharmacogenomics and Pharmacogenetics17. Drug Tolerance, Dependence, Addiction18. Drug Resistance19. Role of Molecular Biology in Modern Pharmacology20. Drug Discovery – Sources of New Drugs21. Drug Development – Pre-clinical22. Drug Development – Clinical23. Nutriceuticals24. The FDA