Oligomerization in Health and Disease book cover

Oligomerization in Health and Disease

This special volume of Progress in Molecular Biology and Translational Science focuses on oligomerization in health and disease.


Researchers, professors and graduate students in biochemistry, chemistry, molecular biology, biotechnology, and medicine.

Hardbound, 656 Pages

Published: May 2013

Imprint: Academic Press

ISBN: 978-0-12-386931-9


    "Full of interest not only for the molecular biologist-for whom the numerous references will be invaluable-but will also appeal to a much wider circle of biologists, and in fact to all those who are concerned with the living cell."--BRITISH MEDICAL JOURNAL


  • Section I. Structural, Physico-Chemical, and Evolutionary Aspects of Protein Oligomerization

    1. Evolutionary, Physico-Chemical and Functional Mechanisms of Protein Homooligomerization
    2. Structural, Evolutionary and Assembly Principles of Protein Oligomerization
    3. Physico-Chemical Principles of Protein Aggregation
    4. Structural Aspects of Amyloid Formation
    5. Section II. Oligomerization in Seven-Transmembrane Receptors

    6. Quaternary Structure Predictions and Structural Communication Features of GPCR Dimers
    7. Challenges in the Development of Heteromer-GPCR-Based Drugs
    8. Oligomerization of GPCRs in Health and Disease on "Di/Oligomerisation of GPCRS; Mechanisms and Functional Significance"
    9. G Protein-Coupled Receptor Heterocomplexes in Neuropsychiatric Disorders
    10. Disease-Specific Heteromerization of G Protein-Coupled Receptors that Target Drugs of Abuse
    11. Section III. Oligomerization in Ion Channels

    12. Social Networking among Voltage-Gated Potassium Channels
    13. Oligomerization of the Mitochondrial Protein VDAC1: From Structure to Function and Cancer Therapy
    14. Consequences of Dimerization of the Voltage Gated Proton Channel
    15. Receptor Heteromeric Assembly, How it Works and Why it Matters - The Case of Ionotropic Glutamate Receptors
    16. Section IV. Oligomerization in Enzymes

    17. The Structural Basis for the Allosteric Regulation of Ribonucleotide Reductase
    18. Oligomerization of Dynamin Superfamily Proteins in Health and Disease
    19. Multimerization of the Dnmt3a DNA Methyltransferase and its Functional Implications
    20. Oligomerization in Endoplasmic Reticulum Stress Signaling
    21. Section V. Oligomerization in Regulatory Proteins

    22. Toll-IL-1-Receptor-Containing Adaptor Molecule-1 (TICAM-1), a Signaling Adaptor Linking Innate Immunity to Adaptive Immunity
    23. Assembly of Gamma-Tubulin Ring Complexes: Implications for Cell Biology and Disease
    24. Chemokine Oligomerization in Cell Signaling and Migration
    25. Oligomerization of Rab/Effector Complexes in the Regulation of Vesicle Trafficking


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