Neuropeptides and Brain Function

Edited by

  • E.R. de Kloet
  • V.M. Wiegant
  • D. de Wied

The study of neuropeptides and brain function forms the backbone of a long tradition of original and innovative research carried out at the Rudolph Magnus Institute in Utrecht. A symposium designed to provide a broad overview of the subject was organized to commemorate the 350th anniversary of the University of Utrecht and attracted international experts in the field. Their review papers are published in this volume. The papers are organized into three sections: `Neuropeptides and Adaptation' reviews the role of neuropeptides in brain mechanisms underlying adaptive processes; `Neuropeptides: Basic Concepts' considers more fundamental aspects and the influence of neuropeptides on electrical and molecular processes in the brain; `Neuropeptides, Therapeutic Implications and Future Developments' focusses on the clinical significance of neuropeptides in the treatment of brain aging, regeneration of damaged nerve tissue and neural transplantation. The resulting volume is an outstanding review of value to all interested in brain function and its study in health and disease.
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Book information

  • Published: January 1987
  • Imprint: ELSEVIER
  • ISBN: 978-0-444-80851-6

Table of Contents

Contents: Section 1. Neuropeptides and Adaptation. 1. Adaptation and brain function (P.G. Smelik). 2. Neuroendocrine aspects of adaptation (B.S. McEwen and R.E. Brinton). 3. New designs in neuroendocrine systems (C. Kordon, M.-T. Bluet-Pajot, H. Clauser, S. Drouva, A. Enjalbert and J. Epelbaum). 4. Evolutionary aspects of neuropeptides (J. Joosse). 5. Organization of the stress response at the anatomical level (M. Palkovits). 6. Neuroendocrine states and behavioral and physiological stress responses (B. Bohus, R.F. Benus, D.S. Fokkema, J.M. Koolhaas, C. Nyakas, G.A. van Oortmerssen, A.J.A. Prins, A.J.H. de Ruiter, A.J.W. Scheurink and A.B. Steffens). 7. Brain and immune system: a one way conversation or a genuine dialogue? (R.E. Ballieux and C.J. Heijnen). 8. Conditioned immune responses: adenocortical influences (R. Ader). Section II. Neuropeptides: Basic Concepts. 9. The neuropeptide concept (D. de Wied). 10. Neurohypophyseal hormones and behavior (G.L. Kovács, G. Szabó, Z. Sarnyai and G. Telegdy). 11. Neuropeptides and neurotransmitters involved in regulation of Corticotropin-releasing Factor-containing neurons in the rat (É. Mezey, W.S. Young III, R.E. Siegel and K. Kovács). 12. Gene expression for behavioral relevant peptides in hypothalamic neurons (D.W. Pfaff). 13. Cell biology of the neural circuit for steroid-dependent female reproductive behavior (R.S. Cohen). 14. The cell biology and development of vasopressinergic and oxytocinergic neurons (H. Gainer, M. Altstein and M.H. Whitnall). 15. Brain vasopressin: from electrophysiological effects to neurophysiological significance (I.J.A. Urban). 16. Neurohypophyseal hormone receptor systems in brain and periphery (S. Jard, C. Barberis, S. Audigier and E. Tribollet). 17. Analysis of receptor-coupler events in neuropeptide action using clonal cell lines (M.R. Hanley). 18. Tachykinin receptors in the CNS (J. Glowinski, Y. Torrens, M. Saffroy, L. Bergström, J.C. Beaujouan, S. Lavielle, O. Ploux, G. Chassaing, A. Marquet). 19. Imaging of neuropeptide - neurotransmitter interactions (W.H. Rostène, A. Sarrieau, E. Moyse, D. Hervé, P. Kitabgi, B.S. McEwen, M. Vial, J.P. Tassin, J.P. Vincent and A. Beaudet). 20. Molecular diversity and cellular functions of neuropeptides (F.E. Bloom). Section III. Neuropeptides: Therapeutic Implication and Future Developments. 21. Possible therapeutic implications of the effects of some peptides on the brain (A.J. Kastin, R.H. Ehrensing, W.A. Banks and J.E. Zadina). 22. The role of peptides in affective disorders: A review (A.J. Prange, Jr., J.C. Garbutt, P.T. Loosen, G. Bisset and C.B. Nemeroff). 23. Animal and clinical research on neuropeptides and schizophrenia (J.M. van Ree, W.M.A. Verhoeven and D. de Wied). 24. Neuropeptides and dementia (P. Kragh-Sørenson and A. Lolk). 25.Modulation of brain aging correlates by long-term alterations of adrenal steroids and neurally-active peptides (P.W. Landfield). 26. Suprachiasmatic nucleus in aging, Alzheimer's disease, transsexuality and Prader - Willi syndrome (D.F. Swaab, B. Roozendaal, R. David, D.N. Velis, L. Gooren and R.S. Williams). 27. ACTH neuropeptide stimulation of serotonergic neuronal maturation in tissue culture: modulation by hippocampal cells (E.C. Azmitia and E.R. de Kloet). 28. On the neurotrophic action of melanocortins. (W.H. Gispen, P. De Koning, R.R.D. Kuiters, C.E.E.M. Van der Zee and J. Verhaagen). 29. Grafts of fetal septal cholinergic neurons to the hippocampal formation in aged or fimbria-fornix lesioned rats (A. Björklund and F.H. Gage)