Mouse Models of Developmental Genetic Disease book cover

Mouse Models of Developmental Genetic Disease

Approximately three percent of newborn humans have congenital anomalies with significant cosmetic and/or functional consequences. Much of our ability to understand what has gone awry in these birth defects rests with development of animal models for them; the mouse has emerged as the model organism of choice for these studies. This volume reviews mouse models of specific developmental genetic diseases, including neural tube defects; cleft lip and/or palate; congenital heart disease; ciliopathies; hereditary deafness and others to provide conceptual insight into congenital anomalies generally. The interplay between clinical observation and murine model systems is expected to yield deep insight into mammalian developmental processes and the emergence of effective preventive and/or therapeutic strategies.

Audience
Graduate students and scientists in developmental biology

Hardbound, 512 Pages

Published: December 2008

Imprint: Academic Press

ISBN: 978-0-12-374454-8

Contents

  • 1) Comprehensive Phenotyping of Genetically Modified Mice to Identify New Target Disease IndicationsAuthor: Sandra Engle2) Modeling the Repair Process in Multiple SclerosisAuthor: H. Arnett3) Mouse Genetic Models for Individualized Symptomatology of Cancer and Infectious DiseaseAuthor: P. Demant4) New Rodent Models for Obesity, Diabetes, and Metabolic SyndromeAuthor: R. Peterson5) Mouse Models of Huntingdon’s DiseaseAuthor: L. Menalled, M. Chesselet6) Mouse Models for Ocular DiseaseAuthor: L. Molday7) Hyperlipidemia-Induced AtherosclerosisAuthor: A. Daugherty 8) Mouse Models for Mitochondrial DiseaseAuthors: D. Wallace

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