Macrolide Antibiotics book cover

Macrolide Antibiotics

Chemistry, Biology, and Practice

Macrolide Antibiotics: Chemistry, Biochemistry, and Practice, Second Edition explores the discovery of new macrolide antibiotics, their function, and their clinical use in diseases such as cancer, AIDS, cystic fibrosis and pneumonia. This book discusses the creation of synthetic macrolides and the mechanisms of antibiotic activity. The uses for antimicrobial macrolides in clinical practice are also covered. This book is designed to appeal to both the basic and applied research communities interested in microbiology, bacteriology, and antibiotic/antifungal research and treament.

Audience
Researchers in microbiology, bacteriology, and antibiotic/antifungal research and treatment.

Hardbound, 635 Pages

Published: June 2002

Imprint: Academic Press

ISBN: 978-0-12-526451-8

Reviews

  • "...will be of use to students, clinicians, applied and basic scientists, and physicians. Scientists devoted to the study of secondary metabolites will especially welcome this new coverage of an important group of compounds by a leader in the field." -(2003)

Contents


  • Contributors

    Preface

    1. Discovery of New Macrolides

    I. Introduction

    II. Macrolides from Actinomycetes

    III. Macrolides from Bacteria Including Myxobacteria

    IV. Macrolides from Fungi

    V. Macrolides from Plants and Lichens

    VI. Macrolides from Insects

    VII. Other Macrolides

    VIII. Concluding Remarks

    References

    2. Discovery of New Macrolides from Marine Organisms

    I. Introduction

    II. Macrocyclic Lactones of Marine Organism Origin

    III. Concluding Remarks

    References

    3. Chemical Modification of Macrolides

    I. Introduction

    II. Fourteen-Membered Macrolides

    III. Sixteen-Membered Macrolide Antibiotics and the Avermectin Family

    IV. Concluding Remarks

    References

    4. Total Synthesis of Macrolides

    I. Introduction

    II. Synthetic Strategy for Macrolide Synthesis

    III. Total Synthesis of Selected Macrolides

    IV. Concluding Remarks

    References

    5. Biosynthesis, Regulation, and Genetics of Macrolide Production

    I. Introduction

    II. Reaction Mechanism of Polyketide Biosynthesis

    III. Polyketide Synthase

    IV. Genes Encoding Modular Polyketide Synthase

    V. Sugar Biosynthesis

    VI. Genetic Manipulation of PKS Genes

    References

    6. Pharmacokinetics and Metabolism of Macrolides

    I. Introduction

    II. Pharmacokinetics and Metabolism

    III. Drug Interaction

    IV. Concluding Remarks

    References

    7. Antimicrobial Macrolides in Clinical Practice

    I. Introduction

    II. Fourteen- and Fifteen-Membered Macrolides

    III. Sixteen-Membered Macrolides

    IV. Concluding Remarks

    References

    8. Ivermectin in Clinical Practice

    I. Introduction

    II. Novel Activity of Ivermectin in Clinical Practice

    III. Concluding Remarks

    References

    9. Tacrolimus and Other Immunosuppressive Macrolides in Clinical Practice

    I. Introduction

    II. Tacrolimus, a Brief Developmental History

    III. Novel Activity of Tacrolimus and Other Immunosuppressive Macrolides in Clinical Practice

    IV. Concluding Remarks

    References

    10. Mode of Action and Resistance Mechanisms of Antimicrobial Macrolides

    I. Introduction

    II. Mode of Action of Macrolide Antibiotics

    III. Mechanisms of Resistance to Antimicrobial Macrolides

    IV. Important Developments in Macrolide Antibiotics

    V. Concluding Remarks

    VI. Addendum

    References

    11. Mode of Action of Macrolides with Motilin Agonistic Activity--Motilides

    I. Introduction

    II. Mode of Action of Motilin

    III. Invention of Motilides

    IV. BiologicalActivity of Motilides

    V. Clinical Trials of Motilides

    VI. Concluding Remarks

    References

    12. Novel Activity of Erythromycin and Its Derivatives

    I. Erythromycin Treatment in Diffuse Panbronchiolitis

    II. Inhibition of Chloride Channel

    III. Effects of Macrolides on Cytokine/Chemokine Expression

    IV. Modulation of Bacterial Function

    V. New Challenge for Novel Action

    References

    13. Mode of Action of Avermectin

    I. Introduction

    II. Target of Avermectin Action

    III. Cloning and Structure of Avermectin Binding Protein

    IV. Concluding Remarks

    References

    14. Mode of Action of FK506 and Rapamycin

    I. Introduction

    II. Initial Cellular Target for FK506 and Rapamycin; Peptidyl Prolylcis-trans Isomerases (Rotamases, Immunophilins)

    III. Target of FK506-FKBP12 Complex: Calcineurin

    IV. Target of Rapamycin-FKBP12 Complex: mTOR/FRAP/RFAT

    V. Intervention of Intracellular Signaling Pathways by FK506 and Rapamycin

    References

    Index

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