Miniaturized Systems for (Bio)Chemical Analysis and Synthesis

Edited by

  • Edwin Oosterbroek, University of Twente, Enschede, The Netherlands
  • A. van den Berg, University of Twente, Enschede, The Netherlands

In the past ten years there has been a rapid growth of the research and application area known as Lab-on-a-Chip. After an initial focus on electrokinetic separation techniques on chip, the scope of the field has widened to include topics like microfluidics, DNA analysis, cell analysis, microreactors and mass spectrometer interfacing. As well as the analytical chemistry community, synthetic chemists, chemical engineers, biochemists and biomedical engineers are now also becoming more and more interested in using new micro- and nanotechnological techniques.This first Lab-on-a-Chip book contains a broad collection of papers on microtechnology, microfluidics, analytical methods and applications. All contributions are written by leading researchers in their respective fields, and provide new scientists with an overview of the field, to make him/her aware of the enormous opportunities offered by modern technology. The work presented in this book will definitely stimulate readers to new ideas and concepts, and lead to further innovations in this area.
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Universities, research organisations and private companies, world-wide, working in the field of micro Total Analysis Systems.


Book information

  • Published: October 2003
  • Imprint: ELSEVIER
  • ISBN: 978-0-444-51100-3

Table of Contents

I TECHNOLOGIESHydrogels and polymers as components of a lab on a chipMicroreplication technologies for polymer-based ┬ÁTAS applicationsSilicon and glass micromachining for ┬ÁTASSurface chemistry in polymer microfluidic systemsPlastic microfluidic devices: electrokinetic manipulations, life science applications, and production technologiesII METHODSTransverse diffusion in microfluidic systemsNanoliter & picoliter liquid handlingMicro sequential injection system for monitoring of metabolites extruded by cultured cellsIII CELL- & BEAD-BASED SYSTEMSHandling of beads in microfluidic devices for biotech applicationsParticles and molecules handling in micro channelsCell counting and cell sizing in microstructuresIV APPLICATIONSMicrofabricated capillary array electrophoresis: implementation and applicationsMicrofluidic systems for analysis of the proteome with mass spectrometryInterfacing ┬ÁTAS to matrix assisted laser desorption time-of-flight masspectrometry - MALDI-TOF MSMicro integrated chemical systems for general useSynthesis in micro reactors using electro-osmotic flowBiochips aiming at advanced medical treatmentBioMEMS for drug delivery applications