Infection and Autoimmunity

Edited by

  • Yehuda Shoenfeld, Head: Zabludowicz Center for Autoimmune Diseases,Sheba Medical Center, Affiliate of Tel-Aviv University, Israel
  • Nancy Agmon-Levin, Deputy Head: Zabludowicz Center for Autoimmune Diseases,Sheba Medical Center, Affiliate of Tel-Aviv University, Israel
  • Noel R Rose, Director, Center for Autoimmune Disease Research, Bloomberg School of Public Health, John's Hopkins University, Baltimore, MD, USA
  • Yehuda Shoenfeld, Zabludowicz Center for Autoimmune Diseases,Sheba Medical Center, Affiliate of Tel-Aviv University, Israel
  • Noel R Rose, Director, Center for Autoimmune Disease Research, Bloomberg School of Public Health, John's Hopkins University, Baltimore, MD, USA

Infection and Autoimmunity encompasses the different mechanisms involved in the infection-autoimmunity association/induction. Special attention is given to heat shock proteins (HSPs) and to transgenic mouse models to better understand infection-induced autoimmunity. Organized into six parts, this book first discusses the mechanisms of autoimmune induction by infection. Some chapters follow discussing the vaccination and vaccines, including the controversial issue of vaccine-autoimmunity relationship. Other chapters elucidate the relationship of bacteria and parasites to autoimmunity. Lastly, the aspects of infections and diseases are described. This reference material will help readers gain a deeper insight into the important etiological aspects of autoimmunity.
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Book information

  • Published: September 2004
  • Imprint: ELSEVIER
  • ISBN: 978-0-444-51271-0


Table of Contents


List of Contributors

Introduction: Infection and Autoimmunity

I Mechanisms of Autoimmune Induction by Infection

Implications of T Cell Receptor Crossreactivity for the Pathogenesis of Autoimmune Diseases

Epitope Spreading

Molecular Mimicry in Multiple Sclerosis: Role of MHC-Altered Peptide Ligands (MAPL)

Adverse Events of Desirable Gain in Immunocompetence: The Immune Restoration Inflammatory Syndromes (IRIS)

CD5-Expressing B Cells and Infection

Endothelial Cell Autoreactivity and Infection

II Vaccination

Induction of Autoimmunity by Adjuvant Hydrocarbons

Vaccination and Autoimmunity

BCG Vaccination

III Viruses

Viruses: The Culprits of Autoimmune Diseases?

How Transgenic Mouse Models Contribute to a Better Understanding of Virus-Induced Autoimmunity

Epstein-Barr Virus and Autoimmunity

HIV and Autoimmunity

Parvovirus B19 Infection and Its Association to Autoimmune Disease

Hepatitis C Infection and Vasculitis

HCV and Cryoglobulinemia

Virus-Induced Systemic Vasculitides

Viral Infections and Autoimmune Hepatitis

Viral Infections and Type 1 Diabetes

Theiler's Murine Encephalomyelitis Virus-Induced Demyelinating Disease (TMEV-IDD) and Autoimmunity

Viruses and Multiple Sclerosis

Endogenous Retroviruses as Etiological Agents in Systemic Lupus Erythematosus

Sjögren's Syndrome - Autoimmune Epithelitis: Role of Coxsackieviruses in Pathogenesis

Viral Infection and Heart Disease: Autoimmune Mechanisms

IV Bacteria and Autoimmunity

Rheumatic Fever: How Streptococcal Throat Infection Triggers an Autoimmune Disease

Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections (PANDAS)

Helicobacter Pylori Infection and Gastric Autoimmunity: Coincidence or Cause-Effect Relationship?

Yersinia Enterocolitica Infections and Autoimmune Thyroid Diseases

Reactive Arthritis (Reiter's Syndrome): Roles of Infection, HLA-B27 and the Immune Response

Bovine Spongiform Encephalopathy as an Autoimmune Disease Evoked by Acinetobacter: Implications for Multiple Sclerosis and Creutzfeldt-Jakob Disease

Infection and Autoimmunity in Patients with Antibiotic Treatment-Resistant Lyme Arthritis

Post-Infectious Arthritis: Reactive Arthritis or Slow Infectious Arthritis?

V Parasites and Autoimmunity

Parasitic Infection and Autoimmunity

Autoimmunity in Chagas' Disease

Anti-Saccharomyces Cerevisiae Antibodies and Autoimmune Diseases

VI Infection and Diseases

The Infectious Origin of the Antiphospholipid Syndrome

SLE and Infections

Type I Diabetes Mellitus, Infection and Toll-like Receptors

Infection and Autoimmune Thyroid Diseases

Pemphigus and Infection

Infection, Autoimmunity and Autoimmune Liver Diseases

Infections and Vasculitis

Infection and Multiple Sclerosis

Infections and Polymyositis-Dermatomyositis

Infection and Guillain-Barré Syndrome

Infection and Systemic Sclerosis

Tuberculosis and SLE-like Symptoms as a Complication of Biological Anti-TNF Therapy

Infection and Behçet's Syndrome

Infections and Immune Thrombocytopenic Purpura

Inflammatory Bowel Disease

Infection and Spondyloarthropathies

Celiac Disease and Infection

Infections Associated with Retinal Autoimmunity

Infection and Atherosclerosis

The Pathogenic Role of Heat Shock Proteins in Atherosclerosis

Interaction between Rheumatoid Arthritis and Infections

Subject Index