Histone Deacetylase Inhibitors as Cancer Therapeutics

Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. This thematic volume looks at "Histone Deacetylase Inhibitors as Cancer Therapeutics."
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Researchers and students in the basic and clinical sciences of cancer biology and oncology, plus related areas in genetics, immunology, pharmacology, cell biology, and molecular biology.


Book information

  • Published: November 2012
  • ISBN: 978-0-12-394387-3

Table of Contents

    1. Histone Deacetylase Inhibitors Disrupt the Mitotic Spindle Assembly Checkpoint by Targeting Histone and Non-Histone Proteins
    2. Brian Gabrielli and Mellissa Brown

    3. Mechanisms of Resistance to Histone Deacetylase Inhibitors
    4. Ju-Hee Lee, Megan L. Choy and Paul A. Marks

    5. HDAC Inhibitors: Roles of DNA Damage and Repair
    6. Carine Robert and Feyruz V. Rassool

    7. HDAC Inhibitor Modulation of Proteotoxicity as a Therapeutic Approach in Cancer
    8. David J. McConkey, Matthew White, and Wudan Yan

    9. Intrinsic and Extrinsic Apoptotic Pathway Signaling as Determinants of Histone Deacetylase Inhibitor Anti-Tumor Activity
    10. Geoffrey M Matthews, Andrea Newbold and Ricky W. Johnstone

    11. Histone Deacetylase Inhibitors and Rational Combination Therapies
    12. Steven Grant

    13. HDAC Inhibitors and Chaperone Function

    Rekha Rao, Siddhartha Ganguly, Suman Kambhampati and Kapil N. Bhalla