Herb, Nutrient, and Drug Interactions

Clinical Implications and Therapeutic Strategies


  • Mitchell Stargrove, ND, LAc, Founder/Developer, IBIS: The Integrative BodyMind Information System; President, MedicineWorks.com/Health Resources Unlimited, Inc., Beaverton, OR, USA
  • Jonathan Treasure, MA, MNIMH, RH (AHG), MCPP, Centre for Natural Healing, Ashland, OR, USA
  • Dwight McKee, MD, Diplomate, American Boards of Internal Medicine, Medical Oncology and Hematology, Aptos, CA, USA

Presenting detailed, evidence-based coverage of the most commonly encountered therapeutic agents in modern clinical practice, this resource is designed to help you safely and effectively integrate herbal, nutrient, and drug therapy for your patients or clients. Combining pharmaceuticals with herbs or supplements may complement or interfere with a drug’s therapeutic action or may increase adverse effects. Additionally, drug-induced depletion of nutrients can occur. Comprehensive clinical data, quick-reference features, and the insight and expertise of trusted authorities help you gain a confident understanding of how herbal remedies and nutritional supplements interact with pharmaceuticals and develop safe, individualized treatment strategies for your patients.
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Book information

  • Published: December 2007
  • Imprint: MOSBY
  • ISBN: 978-0-323-02964-3


LE Magazine April 2009
New Book Provides Definitive Guide to Supplement-Drug Interactions

The recent release of the landmark textbook Herb, Nutrient, and Drug Interactions: Clinical Implications and Therapeutic Strategies provides the most detailed, complete source of information available on how commonly used herbs and nutrients interact with medications. Using these therapies together can support or interfere with a drug's action, or lead to adverse effects.

The book is co-authored by a team of practicing health care professionals with special expertise in integrative medicine: Dr. Mitchell Stargrove, a naturopathic physician, Jonathan Treasure, an authority on medical herbalism, and Dr. Dwight L. McKee, a diplomat of the boards of Internal Medicine, Medical Oncology, and Hematology. Over 60 of the most commonly used herbs and nutrients are covered in depth.

This collaborative effort goes beyond previous books on herb-drug-nutrient interactions in that it analyzes the source, strength, and relevance of the scientific studies, and clearly presents the information in a clinically relevant format. Special consideration is also given to how nutrients are depleted from the body by specific medications.

Access to accurate, clinically relevant information on herb-drug and nutrient-drug interactions is vital to anyone combining therapies. Herb, Nutrient, and Drug Interactions: Clinical Implications and Therapeutic Strategies provides consumers with the ability to work with their doctors to confidently design safe and effective integrative treatment plans.

-Michael J. Hall, ND

* Stargrove MB, Treasure J, McKee DL. Herb, Nutrient, and Drug Interactions: Clinical Implications and Therapeutic Strategies. St. Louis, MO: Mosby Elsevier; 2008.



The Pharmaceutical Journal

This is a useful reference book for a pharmacy and will help pharmacists involved in medicines use reviews or advising on the use of herbal products or food supplements in the context of conventional medicines to give evidence-based information to patients.

-Pam Mason

Table of Contents

Interactions Probability, Significance and Source Strength Guides

Section I: Herbs Interacting with Drugs

Aloe (Aloe vera)

Astragalus (Astragalus membranaceus)

Bilberry (Vaccinium myrtillus)

Black Cohosh (Cimicifuga racemosa)


Cayenne (Capsicum)

Dang Gui (Angelica sinensis)

Devil's Claw (Harpagophytum procumbens)

Echinacea (Echinacea spp.)

Eleuthero (Eleutherococcus senticosus)

Ephedra (Ephedra sinica)

Feverfew (Tanacetum parth.)

Garlic (Allium sativum)

Ginger (Zingiber off.)

Ginkgo (Ginkgo biloba)

Ginseng, Chinese/Korean (Panax ginseng)

Gotu Kola (Centella asiatica)

Green Tea (Camellia sinensis)

Hawthorn (Crataegus)

Horse Chestnut (Aesculus hippocastanum)

Kava Kava (Piper methysticum)

Licorice Root (Glycyrrhiza glabra)

Milk Thistle Seed (Silybum marianum)

Red Clover (Trifolium pratense)

Reishi Mushroom (Ganoderma lucidum)

Saw Palmetto (Serenoa repens)

St. John's Wort (Hypericum perforatum)

Turmeric/Curcumin (Curcuma longa)

Valerian (Valeriana off.)

Vitex/Chaste (Vitex agnus-castus)

Section II: Nutrients Interacting with Drugs and Drug-Induced Nutrient Depletions

A. Vitamins


Folic Acid

Vitamin A / Retinol

Vitamin B1 / Thiamine

Vitamin B2 / Riboflavin

Vitamin B3 / Niacin/Niacinamide

Vitamin B6

Vitamin B12

Vitamin C / Ascorbic Acid

Vitamin D / Calciferol

Vitamin E

Vitamin K

B. Minerals










C. Amino Acids







D. Nutriceuticals and Physiologics

5-HTP (5-Hydroxytryptophan)

Alpha Lipoic Acid

Chondroitin Sulfate

Coenzyme Q10

DHEA (Dehydroepiandrosterone)

Glucosamine sulfate



Omega 3 Fatty Acids (including Fish Oils: DHA and EPA)

PABA (Para-aminobenzoic Acid)


Probiotic Intestinal Flora and Prebiotics

S-adenosyl Methionine (SAMe)

Section III: Cross Indexes

A. Drugs by Trade Names

B. Drugs by Generic Names

C. Drugs by Drug Classes