Haschek and Rousseaux

Haschek and Rousseaux's Handbook of Toxicologic Pathology

Haschek and Rousseaux's Handbook of Toxicologic Pathology is a key reference on the integration of structure and functional changes in tissues associated with the response to pharmaceuticals, chemicals and biologics. The 3e has been expanded by a full volume, and covers aspects of safety assessment not discussed in the 2e. Completely revised with many new chapters, it remains the most authoritative reference on toxicologic pathology for scientists and researchers studying and making decisions on drugs, biologics, medical devices and other chemicals, including agrochemicals and environmental contaminants. New topics include safety assessment, the drug life cycle, risk assessment, communication and management, carcinogenicity assessment, pharmacology and pharmacokinetics, biomarkers in toxicologic pathology, quality assurance, peer review, agrochemicals, nanotechnology, food and toxicologic pathology, the environment and toxicologic pathology and more.


Scientists, including pathologists, toxicologists and graduate students, in academia, industry and government. Potential settings include biopharmaceutical, medical device, and chemical companies; contract and basic research organizations; veterinary diagnostic laboratories and medical forensic laboratories.


Published: June 2013

Imprint: Academic Press

ISBN: 978-0-12-415759-0


  • "The 3 volumes are well organized, and the editors have endeavored to provide clearer and more complete content description for chapter titles that will be easier for nonpathologist to recognize.…This…handbook belongs on the physical- or e-shelf of practitioners of toxicologic pathology and toxicology and needs to be in the communal library of a broad range of individuals in life sciences who interact with toxicologic pathologists."--International Journal of Toxicology, December 2, 2013
    "The 2 volumes are excellent companions that complement each other as a "1,2" punch! This publication should be on the bookshelf of clinical toxicologists, environmental professionals and laboratory investigators..."--VETERINARY AND HUMAN TOXICOLOGY (October 2002)
    "...gives an excellent overview of the numerous processes associated with toxicologic pathology as used in risk assessment. It stands alone as a classic textbook in toxicology, or would be an excellent supplement to other such books. ...Its readability will allow acceptance to all scientists ranging from undergraduate to experienced industry/regulatory professional."--Paul Baldrick for THE BRITISH TOXICOLOGY SOCIETY NEWSLETTER (Spring 2002)
    "...very readable, well-referenced, and current... an excellent book for research training."--DOODY'S


  • Volume 1: General Toxicologic PathologyPreface.Contributors.Part A: Basics of Toxicologic PathologyToxicologic Pathology: An Introduction.Biochemical Basis of Toxicity.Morphologic Manifestation of Toxic Cell Injury.Organelle Biochemistry and Regulation of Cell Death.Carcinogenesis.Applied Clinical Pathology in Preclinical Toxicology Testing.Nomenclature.Part B: The Practice of Toxicologic PathologyBasic Techniques.Managing Pitfalls in Toxicologic Pathology.Special Techniques in Toxicologic Pathology.Application of New Technologies to Toxicologic Pathology.Issues in Laboratory Animal Science for the Toxicologic Pathologist.New Animal Models in Toxicology.Pathology Issues in the Design of Toxicology Studies.Use and Misuse of Statistics in the Design and Interpretation of Studies.Preparation of the Report for a Toxicology/Pathology Study.Part C: Selected Topics in Toxicologic PathologyRisk Assessment: The Changing Paradigm.Principles of Risk Communication: Building Trust and Credibility with the Public.Biomedical Devices and Biomaterials.Biotechnology and Its Products.Endocrine Disruptors.Radiation and Heat.Nutritional Toxicologic Pathology.Phycotoxins.Mycotoxins.Heavy Metals.Volume 2: Organ Specific Toxicologic PathologyOrgan-Specific Toxicologic Pathology: An Introduction.Respiratory System.Skin and Oral Mucosa.Gastrointestinal Tract.Liver.Pancreas.Kidney.Lower Urinary Tract.Cardiovascular and Skeletal Muscle Systems.Bones and Joints.Nervous System.The Eye.Immune System.Hematopoietic System.Endocrine System.Male Reproduction.Female Reproduction.Embryo and Fetus.Index.


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