Haschek and Rousseaux

Haschek and Rousseaux's Handbook of Toxicologic Pathology

A comprehensive understanding of toxicologic pathology is essential for those in industry, academia, and government who make decisions concerning the safety and efficacy of drugs and chemicals. Toxicologic pathology relies heavily on the fields of both toxicology and pathology, which are well covered individually in various texts and references; however, there are few texts that address the field of toxicologic pathology. The Handbook of Toxicologic Pathology fills this void and is thus essential for all health professionals within or interacting with the field of toxicologic pathology.
This two-volume set provides the reader with a single reference for toxicologic pathology. In volume I, the book covers toxicologic pathology in its basic aspects, including its definition, the basic biochemical and morphologic mechanisms underlying the discipline, the basic practice of toxicologic pathology (including special techniques) and issues essential to the understanding of toxicologic pathology such as risk assessment, experimental design, and statistical analysis. Next, the book moves to specific issues affecting the "practice" toxicologic pathology, including issues such as knowledge management, regulatory affairs and writing pathology reports. Finally, Volume I closes with several chapters that deal with specific classes of environmental toxicants such as endocrine disruptors and heavy metals. Volume II addresses the toxicologic pathology in a thoroughly standardized systems manner, addressing the basic structure and function of a particular organ system, its response to toxic injury, mechanisms of injury and methods of evaluation of such injury.

Audience
Researchers in the area of toxicology and pathology, veterinary scientists, veterinary diagnostic and medical forensic laboratories, and pharmaceutical and chemical companies.

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Published: October 2001

Imprint: Academic Press

ISBN: 978-0-12-330215-1

Reviews

  • "The 2 volumes are excellent companions that complement each other as a "1,2" punch! This publication should be on the bookshelf of clinical toxicologists, environmental professionals and laboratory investigators..."
    -VETERINARY AND HUMAN TOXICOLOGY (October 2002)
    "...gives an excellent overview of the numerous processes associated with toxicologic pathology as used in risk assessment. It stands alone as a classic textbook in toxicology, or would be an excellent supplement to other such books. ...Its readability will allow acceptance to all scientists ranging from undergraduate to experienced industry/regulatory professional."
    -Paul Baldrick for THE BRITISH TOXICOLOGY SOCIETY NEWSLETTER (Spring 2002)
    "...very readable, well-referenced, and current... an excellent book for research training."
    --DOODY'S

    "[W]ell illustrated with good quality diagrams, colour and black and white photographs…. [A]n excellent, eminently readable book to have as a study or reference book, covering the essential basics and providing a good overview for any toxicological pathologist, toxicologist or research scientist with an interest in the pathological changes seen in toxicological studies."--British Toxicology Society Newsletter


Contents

  • Volume 1: General Toxicologic PathologyPreface.Contributors.Part A: Basics of Toxicologic PathologyToxicologic Pathology: An Introduction.Biochemical Basis of Toxicity.Morphologic Manifestation of Toxic Cell Injury.Organelle Biochemistry and Regulation of Cell Death.Carcinogenesis.Applied Clinical Pathology in Preclinical Toxicology Testing.Nomenclature.Part B: The Practice of Toxicologic PathologyBasic Techniques.Managing Pitfalls in Toxicologic Pathology.Special Techniques in Toxicologic Pathology.Application of New Technologies to Toxicologic Pathology.Issues in Laboratory Animal Science for the Toxicologic Pathologist.New Animal Models in Toxicology.Pathology Issues in the Design of Toxicology Studies.Use and Misuse of Statistics in the Design and Interpretation of Studies.Preparation of the Report for a Toxicology/Pathology Study.Part C: Selected Topics in Toxicologic PathologyRisk Assessment: The Changing Paradigm.Principles of Risk Communication: Building Trust and Credibility with the Public.Biomedical Devices and Biomaterials.Biotechnology and Its Products.Endocrine Disruptors.Radiation and Heat.Nutritional Toxicologic Pathology.Phycotoxins.Mycotoxins.Heavy Metals.Volume 2: Organ Specific Toxicologic PathologyOrgan-Specific Toxicologic Pathology: An Introduction.Respiratory System.Skin and Oral Mucosa.Gastrointestinal Tract.Liver.Pancreas.Kidney.Lower Urinary Tract.Cardiovascular and Skeletal Muscle Systems.Bones and Joints.Nervous System.The Eye.Immune System.Hematopoietic System.Endocrine System.Male Reproduction.Female Reproduction.Embryo and Fetus.Index.

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