Handbook of the Biology of Aging

Edited by

  • Edward Masoro, University of Texas, San Antonio, U.S.A.
  • Steven Austad, University of Texas Health Science Center, San Antonio, TX, USA

The Handbook of the Biology of Aging, Sixth Edition, provides a comprehensive overview of the latest research findings in the biology of aging. Intended as a summary for researchers, it is also adopted as a high level textbook for graduate and upper level undergraduate courses. The Sixth Edition is 20% larger than the Fifth Edition, with 21 chapters summarizing the latest findings in research on the biology of aging. The content of the work is virtually 100% new. Though a selected few topics are similar to the Fifth Edition, these chapters are authored by new contributors with new information. The majority of the chapters are completely new in both content and authorship. The Sixth Edition places greater emphasis and coverage on competing and complementary theories of aging, broadening the discussion of conceptual issues. Greater coverage of techniques used to study biological issues of aging include computer modeling, gene profiling, and demographic analyses. Coverage of research on Drosophilia is expanded from one chapter to four. New chapters on mammalian models discuss aging in relation to skeletal muscles, body fat and carbohydrate metabolism, growth hormone, and the human female reproductive system. Additional new chapters summarize exciting research on stem cells and cancer, dietary restriction, and whether age related diseases are an integral part of aging. The Handbook of the Biology of Aging, Sixth Edition is part of the Handbooks on Aging series, including Handbook of the Psychology of Aging and Handbook of Aging and the Social Sciences, also in their 6th editions.
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Gerontological researchers, developmental psychologists, sociologists, practioners dealing with aging populations, biologists involved in aging research, & medical researchers.


Book information

  • Published: December 2005
  • ISBN: 978-0-12-088387-5

Table of Contents

HANDBOOK OF THE BIOLOGY OF AGING, 6eEdited by Edward J. Masoro and Steve AustadSection I: Conceptual and Technical IssuesChapter 1Reliability Theory of Aging and LongevityLeonid A. Gavrilov and Natalia S. GavrilovaChapter 2 - Are Age-Associated Diseases an Integral Part of Aging?Edward J. MasoroChapter 3 - Dietary Restriction, Hormesis and Small Molecule MimeticsDavid A. Sinclair and Konrad T. HowitzChapter 4 - Hematopoietic Stem Cells, Aging, and CancerDeborah Bell and Gary Van ZantChapter 5 - Mitochondria: A Critical Role in AgingTamara Golden, Karl Morten, Felicity Johnson, Enrique Samper, and Simon MelovChapter 6 - P53 and Mouse Aging ModelsCathy Gatza, George Hinkal, Lynette Moore, Melissa Dumble, and Lawrence A. DonehowerChapter 7 - Complex Genetic Architecture of Drosophila LongevityTrudy Mackay, Natalia V. Roshina, Jeff W. Leips, and Elena G. PasyukovaChapter 8 - Evolutionary Biology of Aging: Future DirectionsDaniel Promislow, Ken Fedorka, and Joep BurgerChapter 9 - Senescence in Wild Populations of Mammals and BirdsAnja Brunet-Rossini and Steven N. AustadChapter 10 - Biodemography of Aging and Age-Specific Mortality in Drosophila melanogasterJames Curtsinger, Natalia S. Gavrilova, and Leonid A. GavrilovChapter 11 - Microarray Analysis of Gene Expression Changes in AgingF. Noel Hudson, Matt Kaeberlein, Nancy Linford, David Pritchard, Richard Beyer, and Peter S. RabinovitchChapter 12 - Computer Modeling in the Study of Aging Thomas Kirkwood, Richard Boys, Colin Gillespie, Carole Procter, Daryl Shanley, and Darren WilkensonSection II: Non-Mammalian ModelsChapter 13 - Dissecting the Processes of Aging Using the Nematode Caenorhabditis elegansThomas E. Johnson, Samuel T. Henderson, Shane ReaChapter 14 - Genetic Manipulation of Life span in Drosophila. MelanogasterDaniel Ford and John TowerChapter 15 - Juvenile and Steroid Hormones in Drosophila melanogaster LongevityMeng-Ping Tu, Thomas Flatt,, Marc TatarChapter 16 - A Critical Evaluation of Nonmammalian Models for Aging ResearchSteven N. Austad, Andrej PodlutskySection III: Mammalian ModelsChapter 17 - Differential Aging Among Skeletal MusclesRoger J. M. McCarterChapter 18 - Aging, Body Fat, and Carbohydrate MetabolismMarielisa Rincon, Radhika Muzumdar, and Nir BarzilaiChapter 19 - Growth and Aging: Why do Big Dogs Die young?Richard Miller and Steven N. AustadChapter 20 - Growth Hormone, Insulin-Like Growth Factor-1 and the Biology of AgingChristy S. Carter and William E. SonntagChapter 21 - Aging of the Female Reproductive System Phyllis Wise