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Handbook of Epigenetics

The New Molecular and Medical Genetics

Edited by
  • Trygve Tollefsbol, Professor of Biology, University of Alabama at Birmingham, Birmingham, AL. Dr. Tollefsbol is a Professor of Biology and a Senior Scientist in the Center for Aging, Comprehensive Cancer Center, Nutrition Obesity Research Center, and the Comprehensive Diabetes Center at the University of Alabama at Birmingham (UAB). He is Director of the UAB Cell Senescence Culture Facility which he established in 1999 and a Steering Committee Member of the UAB Center for Aging. Dr. Tollefsbol trained as a Postdoctoral Fellow and Assistant Research Professor with members of the National Academy of Science at Duke University and the University of North Carolina. He earned doctorates in molecular biology and osteopathic medicine from the University of North Texas Health Sciences Center and his bachelor's degree in Biology from the University of Houston. He has received prior funding from the NIA, NCI, NHLBI, NIMH and other federal institutes as well as the Glenn Foundation for Medical Research, Susan G. Komen for the Cure, the American Federation for Aging Research (AFAR), and the American Institute for Cancer Research (AICR) among many other sources. The Glenn Foundation for Medical Research funding was unsolicited and was awarded to Dr. Tollefsbol for lifetime contributions to the field of aging. In 2006 Dr. Tollefsbol was selected and highlighted as part of the 25th anniversary of the AFAR for significant contributions to aging research. Dr. Tollefsbol's research interests have covered a wide range of topics such as aging, epigenetics, nutrition, cancer, telomerase, and caloric restriction. Work from his laboratory has been featured in Women's Health magazine, Shape magazine, and the AICR Newsletter and Dr. Tollefsbol has been a Scientist in the Spotlight in ScienceNow. Currently he serves as an Associate Editor for Frontiers in Epigenomics and is on the Editorial Boards of the international journals Open Longevity Science, Epigenetics of Diabetes and Obesity, Molecular Biot

Hardbound, 638 Pages

Published: September 2010

Imprint: Academic Press

ISBN: 978-0-12-375709-8

Reviews

  • "The Handbook of Epigenetics contains an impressive collection of 37 articles, mainly dealing with the biology of epigenetics. Covered topics range from molecular marks and mechanism, over model systems, epidemiology, aging and the brain to diseases…. In summary, the Handbook of Epigenetics provides a unique and useful combination of information and it is a valuable addition to the bookshelf of scientists with experience in the field."--CHEMBIOCHEM


Contents

  • 1. Epigenetics: The New Science of Genetics

    SECTION I: Molecular Mechanisms of Epigenetics

    2. Mechanisms of DNA Methylation, Methy-CpG Recognition, and Demethylation in Mammals

    3. Mechanisms of Histone Modifications

    SECTION II: Additional Epigenetic Processes

    4. The Epigenetics of Non-coding RNA

    5. Prions and Prion-like Phenomena in Epigenetic Inheritance

    6. Chromosomal Position Effects and Gene Variegation: Impact in Pathologies

    7. Polycomb Mechanisms and Epigenetic Control of Gene Activity

    SECTION III: Epigenetic Technology

    8. Analysis of Gene-specific DNA Methylation

    9. Methods for Assessing Genome-wide DNA Methylation

    10. Methylation of Lysine-9 of Histone H3: Role in Heterochromatin Modulation and Tumorigenesis

    11. Chromatin Modifications Distinguish Genomic Features and Physical Organization of the Nucleus

    12. Assessing Epigenetic Information

    SECTION IV: Model Organisms of Epigenetics

    13. Epigenetics of Eukaryotic Microbes

    14. Drosophila Epigenetics

    15. Mouse Models of Epigenetic Inheritance

    16. Epigenetic Regulatory Mechanisms in Plants

    SECTION V: Metabolism and Epigenetics
     
    17. Metabolic Regulation of DNA Methylation in Mammals

    18. Dietary and Metabolic Compounds Affecting Chromatin Dynamics/Remodeling 

    SECTION VI: Functions of Epigenetics

    19. Epigenetics, Stem Cells and Cellular Differentiation

    20. Epigenetic Basis of Skeletal Muscle Regeneration

    21. Epigenetics of X Chromosome Inactivation

    22. Genomic Imprinting

    23. Epigenetics of Memory Processes

    24. Transgenerational Epigenetics

    25. Aging Epigenetics

    SECTION VII: Evolutionary Epigenetics
       
    26. Epigenetics in Adaptive Evolution and Development

    SECTION VIII: Epigenetic Epidemiology

    27. The Effects of Diet on Epigenetic Processes

    28. Environmental Agents and Epigenetics

    29. Impact of Microbial Infections on the Human Epigenome and Carcinogenesis

    30. DNA Methylation Profiles in the 5’-Upstream Region of the Human FMR1 Promoter and in an Adenovirus Transgenome

    31. Population Pharmacoepigenomics

    SECTION IX: Epigenetics and Human Disease

    32. Cancer Epigenetics

    33. The Role of Epigenetics in Immune Disorders

    34. Epigenetics of Brain Disorders

    35. Complex Metabolic Syndromes and Epigenetics

    36. Imprinting Disorders in Humans

    SECTION X: Epigenetic Therapy

    37. Clinical Applications of Histone Deacetylase Inhibitors

     

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