Handbook of Epigenetics

The New Molecular and Medical Genetics

Edited by

  • Trygve Tollefsbol, Professor of Biology, University of Alabama at Birmingham, AL, USA

Epigenetics is considered by many to be the "new genetics" because of the overwhelming evidence of the contribution of non-genetic factors such as  nutrition, environment, and chemical exposure on gene expression. The effects of epigenetics are vast, including tissue/organ regeneration, X-chromosome inactivation, and stem cell differentiation and genomic imprinting and aging. Aberrations of epigenetics influence many diseases for which clinical intervention is already in place, and many novel epigenetic therapies for cancer, immune disorders, neurological and metabolic disorders, and imprinting diseases are on the horizon.

This comprehensive collection of reviews written by leaders in the field of epigenetics provides a broad view of this important and evolving topic. From molecular mechanisms and epigenetic technology to discoveries in human disease and clinical epigenetics, the nature and applications of the science will be presented for those with interests ranging from the fundamental basis of epigenetics to therapeutic interventions for epigenetic-based disorders.

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Audience

Genetic, genomic, molecular biology, cell biology, regenerative medicine and tissue engineering researchers; disease-specific researchers and clinicians studying cancer and immunological, neurological, and metabolic disorders; environmental scientists; evolutionary biologists; graduate students, postdoctoral fellows/research associates in these areas; pharmaceutical and biotechnology researchers interested in drug development

 

Book information

  • Published: September 2010
  • Imprint: ACADEMIC PRESS
  • ISBN: 978-0-12-375709-8

Reviews

"The Handbook of Epigenetics contains an impressive collection of 37 articles, mainly dealing with the biology of epigenetics. Covered topics range from molecular marks and mechanism, over model systems, epidemiology, aging and the brain to diseases…. In summary, the Handbook of Epigenetics provides a unique and useful combination of information and it is a valuable addition to the bookshelf of scientists with experience in the field."--CHEMBIOCHEM




Table of Contents

1. Epigenetics: The New Science of Genetics

SECTION I: Molecular Mechanisms of Epigenetics

2. Mechanisms of DNA Methylation, Methy-CpG Recognition, and Demethylation in Mammals

3. Mechanisms of Histone Modifications

SECTION II: Additional Epigenetic Processes

4. The Epigenetics of Non-coding RNA

5. Prions and Prion-like Phenomena in Epigenetic Inheritance

6. Chromosomal Position Effects and Gene Variegation: Impact in Pathologies

7. Polycomb Mechanisms and Epigenetic Control of Gene Activity

SECTION III: Epigenetic Technology

8. Analysis of Gene-specific DNA Methylation

9. Methods for Assessing Genome-wide DNA Methylation

10. Methylation of Lysine-9 of Histone H3: Role in Heterochromatin Modulation and Tumorigenesis

11. Chromatin Modifications Distinguish Genomic Features and Physical Organization of the Nucleus

12. Assessing Epigenetic Information

SECTION IV: Model Organisms of Epigenetics

13. Epigenetics of Eukaryotic Microbes

14. Drosophila Epigenetics

15. Mouse Models of Epigenetic Inheritance

16. Epigenetic Regulatory Mechanisms in Plants

SECTION V: Metabolism and Epigenetics
 
17. Metabolic Regulation of DNA Methylation in Mammals

18. Dietary and Metabolic Compounds Affecting Chromatin Dynamics/Remodeling 

SECTION VI: Functions of Epigenetics

19. Epigenetics, Stem Cells and Cellular Differentiation

20. Epigenetic Basis of Skeletal Muscle Regeneration

21. Epigenetics of X Chromosome Inactivation

22. Genomic Imprinting

23. Epigenetics of Memory Processes

24. Transgenerational Epigenetics

25. Aging Epigenetics

SECTION VII: Evolutionary Epigenetics
   
26. Epigenetics in Adaptive Evolution and Development

SECTION VIII: Epigenetic Epidemiology

27. The Effects of Diet on Epigenetic Processes

28. Environmental Agents and Epigenetics

29. Impact of Microbial Infections on the Human Epigenome and Carcinogenesis

30. DNA Methylation Profiles in the 5’-Upstream Region of the Human FMR1 Promoter and in an Adenovirus Transgenome

31. Population Pharmacoepigenomics

SECTION IX: Epigenetics and Human Disease

32. Cancer Epigenetics

33. The Role of Epigenetics in Immune Disorders

34. Epigenetics of Brain Disorders

35. Complex Metabolic Syndromes and Epigenetics

36. Imprinting Disorders in Humans

SECTION X: Epigenetic Therapy

37. Clinical Applications of Histone Deacetylase Inhibitors