Handbook of Epigenetics book cover

Handbook of Epigenetics

The New Molecular and Medical Genetics

Epigenetics is considered by many to be the "new genetics" because of the overwhelming evidence of the contribution of non-genetic factors such as  nutrition, environment, and chemical exposure on gene expression. The effects of epigenetics are vast, including tissue/organ regeneration, X-chromosome inactivation, and stem cell differentiation and genomic imprinting and aging. Aberrations of epigenetics influence many diseases for which clinical intervention is already in place, and many novel epigenetic therapies for cancer, immune disorders, neurological and metabolic disorders, and imprinting diseases are on the horizon.

This comprehensive collection of reviews written by leaders in the field of epigenetics provides a broad view of this important and evolving topic. From molecular mechanisms and epigenetic technology to discoveries in human disease and clinical epigenetics, the nature and applications of the science will be presented for those with interests ranging from the fundamental basis of epigenetics to therapeutic interventions for epigenetic-based disorders.

Audience

Genetic, genomic, molecular biology, cell biology, regenerative medicine and tissue engineering researchers; disease-specific researchers and clinicians studying cancer and immunological, neurological, and metabolic disorders; environmental scientists; evolutionary biologists; graduate students, postdoctoral fellows/research associates in these areas; pharmaceutical and biotechnology researchers interested in drug development

Hardbound, 638 Pages

Published: September 2010

Imprint: Academic Press

ISBN: 978-0-12-375709-8

Reviews

  • "The Handbook of Epigenetics contains an impressive collection of 37 articles, mainly dealing with the biology of epigenetics. Covered topics range from molecular marks and mechanism, over model systems, epidemiology, aging and the brain to diseases…. In summary, the Handbook of Epigenetics provides a unique and useful combination of information and it is a valuable addition to the bookshelf of scientists with experience in the field."--CHEMBIOCHEM


Contents

  • 1. Epigenetics: The New Science of Genetics

    SECTION I: Molecular Mechanisms of Epigenetics

    2. Mechanisms of DNA Methylation, Methy-CpG Recognition, and Demethylation in Mammals

    3. Mechanisms of Histone Modifications

    SECTION II: Additional Epigenetic Processes

    4. The Epigenetics of Non-coding RNA

    5. Prions and Prion-like Phenomena in Epigenetic Inheritance

    6. Chromosomal Position Effects and Gene Variegation: Impact in Pathologies

    7. Polycomb Mechanisms and Epigenetic Control of Gene Activity

    SECTION III: Epigenetic Technology

    8. Analysis of Gene-specific DNA Methylation

    9. Methods for Assessing Genome-wide DNA Methylation

    10. Methylation of Lysine-9 of Histone H3: Role in Heterochromatin Modulation and Tumorigenesis

    11. Chromatin Modifications Distinguish Genomic Features and Physical Organization of the Nucleus

    12. Assessing Epigenetic Information

    SECTION IV: Model Organisms of Epigenetics

    13. Epigenetics of Eukaryotic Microbes

    14. Drosophila Epigenetics

    15. Mouse Models of Epigenetic Inheritance

    16. Epigenetic Regulatory Mechanisms in Plants

    SECTION V: Metabolism and Epigenetics
     
    17. Metabolic Regulation of DNA Methylation in Mammals

    18. Dietary and Metabolic Compounds Affecting Chromatin Dynamics/Remodeling 

    SECTION VI: Functions of Epigenetics

    19. Epigenetics, Stem Cells and Cellular Differentiation

    20. Epigenetic Basis of Skeletal Muscle Regeneration

    21. Epigenetics of X Chromosome Inactivation

    22. Genomic Imprinting

    23. Epigenetics of Memory Processes

    24. Transgenerational Epigenetics

    25. Aging Epigenetics

    SECTION VII: Evolutionary Epigenetics
       
    26. Epigenetics in Adaptive Evolution and Development

    SECTION VIII: Epigenetic Epidemiology

    27. The Effects of Diet on Epigenetic Processes

    28. Environmental Agents and Epigenetics

    29. Impact of Microbial Infections on the Human Epigenome and Carcinogenesis

    30. DNA Methylation Profiles in the 5’-Upstream Region of the Human FMR1 Promoter and in an Adenovirus Transgenome

    31. Population Pharmacoepigenomics

    SECTION IX: Epigenetics and Human Disease

    32. Cancer Epigenetics

    33. The Role of Epigenetics in Immune Disorders

    34. Epigenetics of Brain Disorders

    35. Complex Metabolic Syndromes and Epigenetics

    36. Imprinting Disorders in Humans

    SECTION X: Epigenetic Therapy

    37. Clinical Applications of Histone Deacetylase Inhibitors

     

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