Handbook of Anxiety and Fear

Edited by

  • D. Caroline Blanchard
  • D. Caroline Blanchard
  • Guy Griebel
  • David Nutt, DM FRCP FRCPsych FmedSci , Edmond J Safra Chair in Neuropsychopharmacology, Imperial College London, UK

This Handbook brings together and integrates comprehensively the core approaches to fear and anxiety. Its four sections: Animal models; neural systems; pharmacology; and clinical approaches, provide a range of perspectives that interact to produce new light on these important and sometimes dysfunctional emotions. Fear and anxiety are analyzed as patterns that have evolved on the basis of their adaptive functioning in response to threat. These patterns are stringently selected, providing a close fit with environmental situations and events; they are highly conservative across mammalian species, producing important similarities, along with some systematic differences, in their human expression in comparison to that of nonhuman mammals. These patterns are described, with attention to both adaptive and maladaptive components, and related to new understanding of neuroanatomic, neurotransmitter, and genetic mechanisms. Although chapters in the volume acknowledge important differences in views of fear and anxiety stemming from animal vs. human research, the emphasis of the volume is on a search for an integrated view that will facilitate the use of animal models of anxiety to predict drug response in people; on new technologies that will enable direct evaluation of biological mechanisms in anxiety disorders; and on strengthening the analysis of anxiety disorders as biological phenomena.
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Neuroscientists, Psychologists, Psychopharmacologists, Clinical Psychologists and Psychiatrists


Book information

  • Published: March 2008
  • Imprint: ELSEVIER
  • ISBN: 978-0-444-53065-3


The Handbook of Anxiety and Fear is a lengthy and thorough review of the experimental, neurobiological, pharmacological, and clinical components of anxiety and fear. The text is written at a high level of detail, and the concepts within are supported by lengthy reference sections. This text ... does a wonderful job in covering the scientific basics of the topics.... there is strong coverage of basic science and the current state of knowledge in human clinical scenarios. This text is best suited to professionals and advanced graduate students who research anxiety disorders. Professionals wishing to review the scientific bases of the anxiety disorders would do well to include this book in their personal libraries.
-James J. Jakubow, in PsyCritiques April 1, 2009, Release 13, Article 7

Table of Contents

Section 1. IntroductionIntroduction to the Handbook on Fear and AnxietyRobert Blanchard, D. Caroline Blanchard, Guy Griebel and David NuttSection 2. Animal models of Anxiety, Fear and DefenseTheoretical approaches to the modeling of anxiety in animalsNeil McNaughton and Hélio Zangrossi Jr., The use of conditioning tasks to model fear and anxietyMichael S. Fanselow and Ravikumar PonnusamyExtinction of fear: from animal studies to clinical interventionsKaryn M. Myers and Michael DavisDefensive behaviors, fear and anxietyD. Caroline Blanchard and Robert BlanchardUnconditioned models of fear and anxietyYoav Litvin, Nathan S. Pentkowski, Roger L. Pobbe, D. Caroline Blanchard and Robert J. BlanchardSection 3. Neural Systems for Anxiety, Fear, and DefenseBrain mechanisms of Pavlovian and instrumental aversive conditioningChristopher K. Cain and Joseph E. LeDouxNeural systems activated in response to predators and partial predator stimuliNewton Sabino CanterasA behavioral and neural systems comparison of unconditioned and conditioned defensive behaviorNewton S. Canteras and D. Caroline BlanchardSection 4. The Pharmacology of Anxiety, Fear, and DefensePeptide receptor ligands to treat anxiety disordersThomas StecklerSubtype-selective GABAA/benzodiazepine receptor ligands for the treatment of anxiety disordersJames K. RowlettModulation of anxiety behaviors by 5-HT-interacting drugsFrancisco Silveira Guimarães, Antonio Pádua Carobrez and Frederico Guilherme GraeffThe glutamatergic system as a potential therapeutic target for the treatment of anxiety disordersJohn F. Cryan and Kumlesh K. DevThe endocannabinoid system and anxiety responsesMarco Bortolato and Daniele PiomelliGenetic factors underlying anxiety-behaviour: a meta-analysis of rodent studies involving targeted mutations of neurotransmission genesCatherine Belzung, Samuel Leman and Guy GriebelThe pharmacology of anxiolysisAndrew HolmesSection 5. Handbook of Fear and Anxiety: Clinical and Experimental ConsiderationsPhenomenology of anxiety disordersDavid J. Nutt, Berta Garcia de Miguel and Simon J.C. DaviesHow effective are current drug treatments for anxiety disorders, and how could they be improved?David S. Baldwin and Matthew J. GarnerExperimental models: panic and fearGabriel Esquivel, Koen Schruers and Eric GriezPrinciples and findings from human imaging of anxiety disordersAndrea L. Malizia and David NuttStress hormones and anxiety disordersElizabeth A. Young, James L. Abelson and Israel LiberzonThe genetics of human anxiety disordersEduard Maron, John M. Hettema and Jakov Shlik