G Protein Coupled Receptors book cover

G Protein Coupled Receptors

Modeling, Activation, Interactions and Virtual Screening

      This new volume of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers G protein coupled receptors, and includes chapters on such topics as GPCR modelling, interactions with other molecules, virtual screening and GPCR activation.


Biochemists, biophysicists, molecular biologists, analytical chemists, and physiologists

Included in series
Methods in Enzymology

Hardbound, 528 Pages

Published: February 2013

Imprint: Academic Press

ISBN: 978-0-12-407865-9


  • GPCR Modeling

    1. The Protein Local Optimization Program and G-Protein Coupled Receptors: Loop Restoration and Applications to Homology Modeling
    2. Dahlia A. Goldfeld and Richard A. Friesner

    3. Modeling Active GPCR Conformations
    4. Bruck Taddese, Lisa M Simpson, Ian D Wall, Frank E Blaney and Christopher A Reynolds

    5. Molecular Modeling of Adenosine Receptors
    6. Adriano Martinelli and Gabriella Ortore

    7. Predicting G Protein-Coupled Receptors Families using Different Physiochemical Properties and Pseudo Amino Acid Composition
    8. Zia-ur-Rehman, Muhammad Tayyeb Mirza, Asifullah Khan, Henri Xhaard

    9. Computational Design and Experimental Characterization of GPCR Segment Models
    10. Abby L. Parrill

      GPCR Interactions with Other Molecules and Cross-Talk

    11. G Protein-Coupled Receptor Interaction with Small GTPases
    12. Chunmin Dong and Guangyu Wu

    13. Quantification of Receptor Tyrosine Kinase Activation and Transactivation by G Protein Coupled Receptors Using Spatial Intensity Distribution Analysis (SpIDA)
    14. Annie Barbeau, Antoine G. Godin, Jody L. Swift, Yves De Koninck, Paul W. Wiseman and Jean-Martin Beaulieu

    15. NMR Methods for Detection of Small Molecule Binding to RGS4
    16. Andrew J. Storaska and Richard R. Neubig

    17. Group II Activators of G-protein Signaling: Monitoring the Interaction of Ga with the G-Protein Regulatory Motif in the Intact Cell
    18. Sukru Sadik Oner, Joe B. Blumer and Stephen M. Lanier

    19. Homogeneous Time-Resolved Fluorescence Assay to Probe Folded G Protein-Coupled Receptors
    20. Adam M. Knepp, Thomas P. Sakmar, and Thomas Huber

    21. cAMP Biosensors Applied in Molecular Pharmacological Studies of G Protein-Coupled Receptors
    22. Jesper Mosolff Mathiesen, Line Vedel and Hans Bräuner-Osborne

    23. Rhodopsin-Lipid Interactions Studied by NMR
    24. Olivier Soubias and Klaus Gawrisch

      GPCR Bias

    25. Biasing the Parathyroid Hormone Receptor: Relating In Vitro Ligand Efficacy to In Vivo Biological Activity
    26. Kathryn M. Appleton, Mi-Hye Lee, Christian Alele, Christine Alele, Deirdre K. Luttrell, Yuri K. Peterson, Thomas A . Morinelli, and Louis M. Luttrell

      Virtual Screening

    27. Application of Monte Carlo-based Receptor-Ensemble Docking to Virtual Screening for GPCR Ligands
    28. Santiago Vilar and Stefano Costanzi

    29. From Heptahelical Bundle to Hits from the Haystack: Structure-Based Virtual Screening for GPCR Ligands
    30. A.J. Kooistra, L. Roumen, R. Leurs, I.J.P. de Esch, C. de Graaf

      GPCR Activation

    31. Kinetics and Dynamics in the G-Protein Coupled Receptor Signaling Cascade
    32. Jean-Pierre Vilardaga, Timothy N. Feinstein, Vanessa L. Wehbi, and Guillermo Romero

    33. Magic Angle Spinning Nuclear Magnetic Resonance Spectroscopy of G Protein-Coupled Receptors
    34. Joseph Goncalves, Markus Eilers, Kieron South, Chikwado A. Opefi, Philippe Laissue, Philip J. Reeves and Steven O. Smith

    35. Post-Translation Modification of G Protein-Coupled Receptor in Relationship to Biased Agonism
    36. Hui Zheng, Horace H. Loh and Ping-Yee Law

    37. Protein S-Nitrosylation Measurement

    Yu Qin, Anindya Dey and Yehia Daaka


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