G Protein-Coupled Receptors in Health and Disease, Part B book cover

G Protein-Coupled Receptors in Health and Disease, Part B

G protein-coupled receptors (GPCRs) transduce signals from a diverse array of endogenous ligands, including ions, amino acids, nucleotides, lipids, peptides, and large glycoprotein hormones. They are also responsible for our sensing of exogenous stimuli, including photons and odorants. GPCRs regulate almost every aspect of our physiological functions. It is estimated that 40% to 50% of currently used therapeutic drugs target GPCRs directly or indirectly. Because the current drugs target only a small portion of the GPCRs, opportunities for targeting the remaining GPCRs is enormous. This volume reviews the latest developments in this rapidly advancing field.

Audience
Researchers, professors and graduate students in biochemistry, chemistry, molecular biology, biotechnology, and medicine

Hardbound, 192 Pages

Published: October 2009

Imprint: Academic Press

ISBN: 978-0-12-374756-3

Reviews

  • PRAISE FOR THE SERIES
    "Full of interest not only for the molecular biologist-for whom the numerous references will be invaluable-but will also appeal to a much wider circle of biologists, and in fact to all those who are concerned with the living cell."-British Medical Journal


Contents

  • 1. Diseased G protein-coupled receptors: An Introduction

    Ya-Xiong Tao

    2. GPR56 and its related diseases

    Xianhua Piao and Ze Tian

    3. GnRHR mutations and hypogonadotropic hypogonadism

    Nicholas de Roux

    4. LHR mutations and reproductive disorders

    Deborah L. Segaloff

    5. FSHR mutations and reproductive disorders

    Ya-Xiong Tao and Deborah L. Segaloff

    6. V2R mutations and nephrogenic diabetes insipidus

    Daniel G. Bichet

    7. Calcium-sensing receptor mutations

    Geoffrey N. Hendy

    8. Diseases caused by prostacyclin receptor mutations

    John Hwa and Kathleen A Martin

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