Foundations of Comparative Genomics


  • Arcady Mushegian, Stowers Institute for Medical Research and Kansas University Medical Center, Kansas City, Missouri, U.S.A.

This book provides an overview of computational analysis of genes and genomes, and of some most notable findings that come out of this work. Foundations of Comparative Genomics presents a historical perspective, beginning with early analysis of individual gene sequences, to present day comparison of gene repertoires encoded by completely sequenced genomes. The author discusses the underlying scientific principles of comparative genomics, argues that completion of many genome sequences started a new era in biology, and provides a personal view on several state-of-the-art issues, such as systems biology and whole-genome phylogenetic reconstructions. This book is an essential reference for researchers and students in computational biology, evolutionary biology, and genetics.
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Researchers and students in computational bioloy, evolutionary biology, and genetics


Book information

  • Published: March 2007
  • ISBN: 978-0-12-088794-1

Table of Contents


1. The Beginning of Computational Genomics

2. Finding Sequence Similarities

3. Homology: Can We Get It Right?

4. Getting Ready for the Era of Comparative Genomics: The Importance of Viruses

5. The First Fact of Comparative Genomics: Protein Sequences are Remarkably Resilient in Evolution

6. The Second Fact of Comparative Genomics: Functional Convergence at the Molecular Level

7. Prediction of Function and Reconstruction of Metabolism from Genomic Data: Homology-Based Approaches

8. Prediction of Function and Reconstruction of Metabolism: Post-Homology Approaches

9. Structural Genomics:What Does It Tell Us about Life?

10. How Many Protein Families are There?

11. Phylogenetic Inference and the Era of Complete Genomes

12. Two Stories about Evolution

13. Minimal and Ancestral Genomes

14. Comparative Genomics and Systems Biology