Fertilization book cover


Fertilization provides in-depth reviews of individual research topics, while emphasizing key concepts and the significance of findings within other fields. The author identifies essential questions to be answered by future research. Fertilization broadly covers the many molecular and cellular events of animal fertilization and includes a section on unique problems and potential applications of fertilization research.

Reproductive endocrinologists, biotechnology industry, OB/GYNs, infertility/fertility and contraception specialists.

Hardbound, 427 Pages

Published: December 2001

Imprint: Academic Press

ISBN: 978-0-12-311629-1


  • Contributors



    Section I Fertilization Events

    1 Gamete Transport

    I. Introduction

    II. Sperm Transport

    III. Oocyte Transport

    IV. A Model for Gamete Transport


    2 Sperm Motility ActIVation and Chemoattraction

    I. Introduction

    II. Assays

    III. Motility Acquisition

    IV. Motility ActIVation

    V. Motility Modulation in the Female ReproductIVe Tract

    VI. Egg-associated Motility Stimulation

    VII. Chemoattraction

    VIII. Concluding Remarks


    3 Capacitation

    I. Introduction

    II. initiation, Propagation, and Termination of Capacitation

    III. Molecular Mechanism of Capacitation

    IV. Physiological Mechanism and Role of Capacitation

    V Conclusions


    4 Function of the Egg's Extracellular Matrix

    I. Introduction

    II. The Cumulus Oophorus

    III. The Zona Pellucida

    IV. Future Directions


    5 Sperm Adhesion to the Extracellular Matrix of the Egg

    I. Introduction

    II. Basic Biology of Sperm-Eem Adhesion

    III. Identification of Eem Adhesion Molecules

    IV. Future Prospects and Directions


    6 Signal Transduction Mechanisms Regulating Sperm Acrosomal Exocytosis

    I. Introduction

    II. Biogenesis and Morphology of the Acrosome

    III. Biological Significance of Acrosomal Exocytosis

    IV. Physiological Site of Acrosomal Exocytosis

    V. The Zona Pellucida and Progesterone as Physiological Inducers of Acrosomal Exocytosis

    VI. Sperm-associated Receptor/Binding Proteins for the Zona Pellucida and Progesterone

    VII. Signal Transduction Mechanisms Mediating the Effects of the Zona Pellucida and Progesterone


    7 Regulation of Sperm Lon Currents

    I. Importance of Ion Channels

    II. Sperm Ion Transport and EnVIronmental Sensing

    III. Modulation of Sperm Ion Transport by Diffusible Egg Components

    IV. Modulation of Sperm Ion Transport During the Acrosome Reaction

    V. Spermatogenic Cells, A New Tool To Study Sperm Ion Channels

    VI. Concluding Remarks


    8 Function of the Sperm Acrosome

    I. Introduction

    II. The Prevailing View: the Acrosome Reaction Model

    III. An AlternatIVe Paradigm: the Acrosomal Exocytosis Model

    IV. Other Considerations of Acrosomal Proteins

    V. Future Directions

    VI. Summary


    9 Gamete Fusion in Mammals

    I. Introduction

    II. Specificity of Gamete Fusion

    III. A Hypothetical Pathway Leading to Sperm-Egg Fusion

    IV. Sperm and Egg Surface Proteins Involved in Gamete Binding and Fusion

    V. Hypothetical Steps After Binding and Before Fusion

    VI. Sperm Tail Stiffening

    VII. Fusion in Other Systems

    VIII. Prospectus


    10 Membrane Events of Egg Activation

    I. Introduction

    II. Ca2+ Waves and Oscillations At Fertilization

    III. Electrical Events and Fertilization

    IV. The Latent Period of Fertilization 327

    V. Signaling Molecules and Mechanisms Leading To Ca2+ Release

    VI. Sperm as a Ca2+ Conduit

    VII. Sperm Contact as the Signal

    VIII. The Sperm Content Hypothesis

    IX. Conclusions


    Section II Unique Problems and Applications

    11 Molecular Genetics of Fertilization

    I. Introduction

    II. Gametes Have Unusual Characteristics

    III. Genetic Model Systems


    12 Gamete Immunobiology

    I. Introduction

    II. Fetal and Neonatal Germ Cells

    III. The Developing Immune System

    IV. Immune Response To Gametes in the Fetal, Neonatal, and Prepubertal Stages

    V. Immune Response To Gametes in the Adult

    VI. Immune Response To Male Gametes in the Adult Female

    VII. Concluding Remarks


    13 Fertilization Biophysics

    I. Introduction

    II. Sperm as Force-Generating Machines

    III. Tethering Sperm

    IV. Sperm Capture By Eggs

    V. Sperm Penetration of Egg Coats

    VI. The Transition From Sperm Adhesion To Penetration of the Zona Pellucida

    VII. Summary


    14 Applications of Fertility Regulation for the Management of Wild and Domestic Species

    I. Introduction

    II. Case Studies On Wildlife Management

    III. Fertility Control: Targets and Immunological Intervention

    IV. Reproductive Tract Immune Responses

    V. Bait DelIVery of An ImmunocontraceptIVe Vaccine

    VI. Concluding Remarks




advert image