Drug-Induced Liver Disease book cover

Drug-Induced Liver Disease

This field has shown tremendous growth in recent years, primarily due to the recognition that drug-induced liver disease is the most common cause of liver failure and one of the major contributors to the withdrawal of drugs developed by the pharmaceutical industry. Drug-Induced Liver Disease, 3rd edition is a comprehensive reference that covers mechanisms of injury, diagnosis and management, major hepatotoxins, regulatory perspectives and much more. Written by highly respected authorities, this new edition is an updated and definitive reference for clinicians and scientists in academia, the pharmaceutical industry and government settings. This book contains 4 new chapters on key topics in the area and provides a current and extensive review of the latest developments concerning the toxicology, pharmacology, genetics and immunology of drug-induced liver disease.


This reference is geared primarily towards medical specialists, including gastroenterologists, hepatologists, and pathologists, toxicologists, members of the pharmaceutical industry, and regulators.  This book also provides an extensive review of mechanisms of toxicity and of drug safety and would be an excellent reference for students of toxicology, as a secondary audience.

Hardbound, 776 Pages

Published: May 2013

Imprint: Academic Press

ISBN: 978-0-12-387817-5


  • "This volume is a fascinating read for toxicologists interested in liver toxicity, since it provides an up-to-date view of the many mechanisms of hepatotoxicity… a must-have book which should be kept close at hand, in which case it will be opened regularly by toxicologists concerned with the development and safe use of medications in a practical context."--The British Toxicology Society Newsletter, 2008 (Review of 2nd edition)


  • Part I. Mechanisms of Liver Injury
    Chapter 1: Drug-Induced Liver Injury: Introduction and Overview
    Chapter 2: Cytochrome P450 Activation of Toxins and Hepatotoxicity
    Chapter 3: Mechanistic Role of Acyl Glucuronides
    Chapter 4: Oxidative Stress, Antioxidant Defense and Liver Injury
    Chapter 5: Hepatotoxicity due to Mitochondrial Injury
    Chapter 6: Mechanisms of Cell Death and Relevance to Drug Hepatotoxicity
    Chapter 7: Role of Membrane Transport in Hepatotoxicity and Pathogenesis of Drug-Induced Cholestasis
    Chapter 8: Liver Sinusoidal Endothelial Cell and Liver Injury
    Chapter 9: Macrophages and Kupffer Cells in Hepatotoxicity
    Chapter 10: Role of Inflammation in Drug-Induced Liver Disease
    Chapter 11: Role of Adaptive Immune System
    Chapter 12: Role of Tissue Repair in Liver Injury
    Chapter 13: Genetic Factors in Pathogenesis

    Part II. Diagnosis and Management
    Chapter 14: Clinical Manifestations and Management of Drug-Induced Liver Diseases
    Chapter 15: Histopathology of Drug-Induced Liver Disease
    Chapter 16: Risk Factors for Drug-Induced Liver Disease
    Chapter 17: The Promise of Genomics, Proteomics and Metabolomics of Blood and Liver in the Diagnosis of Drug-Induced Liver Disease
    Chapter 18: Causality Assessment

    Part III. Hepatotoxicity of Specific Drugs
    Chapter 19: Mechanisms of Acetaminophen-Induced Liver Disease
    Chapter 20: Acetaminophen – Pathology and Clinical Presentation of Hepatotoxicity
    Chapter 21: Mechanisms Underlying the Hepatotoxicity of Non-Steroidal Anti-Inflammatory Drugs
    Chapter 22: Non-Steroidal Anti-Inflammatory Drugs – Pathology and Clinical Presentation of Hepatotoxicity
    Chapter 23: Mechanisms, Pathology and Clinical Presentation of Hepatotoxicity of Anesthetic Agents
    Chapter 24: Anticonvulsant AgentsChapter 25: Psychotropic Drugs and Drugs of Abuse
    Chapter 26: Hepatotoxicity of Antimicrobials and Antifungal Agents
    Chapter 27: Antituberculosis Agents
    Chapter 28: Hepatotoxicity in Antiviral Agents
    Chapter 29: Hepatotoxicity of Cardiovascular and Antidiabetic Drugs
    Chapter 30: Cancer Chemotherapy
    Chapter 31: Hepatotoxicity of Immunomodulating Agents and the Transplant Situation
    Chapter 32: Methotrexate
    Chapter 33: Hormones and Hormone Antagonists
    Chapter 34: Mushroom Poisoning: A Clinical Model of Toxin-Induced Centrilobular Necrosis
    Chapter 35: Hepatotoxicity and Herbal Medicines, Vitamins and Natural Hepatoxins
    Chapter 36: Occupational and Environmental Hepatotoxicity
    Chapter 37: Chronic Liver Disease from Drugs

    Part IV. Future Directions
    Chapter 38: Regulatory Perspectives
    Chapter 39: Drug-Induced Liver Injury Networks
    Chapter 40: Liver Tox: The Future


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