Drug Discovery and Development book cover

Drug Discovery and Development

Technology in Transition

Audience

Pharmacy students

Pharmacists working in the pharmaceutical industry

Lab technicians

,

Published: July 2012

Imprint: Churchill Livingstone

ISBN: 978-0-7020-5316-0

Contents

  • Contents

    SECTION 1

    INTRODUCTION AND BACKGROUND

    1. The development of the pharmaceutical industry 

    H P Rang

    2. The nature of disease and the purpose of therapy 

    H P Rang, R G Hill

    3. Therapeutic modalities 

    H P Rang, H LeVine, R G Hill

    SECTION 2

    DRUG DISCOVERY

    4. The drug discovery process: general principles and some case histories 

    H P Rang, R G Hill

    5. Choosing the project 

    H P Rang, R G Hill

    6. Choosing the target 

    H P Rang, R G Hill

    7. The role of information, bioinformatics and genomics  

    B Robson, R McBurney

    8. High-throughput screening 

    D Cronk

    9. The role of medicinal chemistry in the drug discovery process 

    P Beswick, A Naylor

    10. DMPK optimization strategy in drug discovery 

    P G Ballard, P Brassil, K H Bui, H Dolgos, C Petersson, A Tunek, P J H Webborn

    11. Pharmacology: its role in drug discovery 

    H P Rang

    12. Biopharmaceuticals 

    H LeVine

    13. Scaffolds: Small globular proteins as antibody substitutes  

    D Grabulovski, J Bertschinger

    SECTION 3

    DRUG DEVELOPMENT

    14. Drug development: introduction

    H P Rang, R G Hill

    15. Assessing drug safety 

    H P Rang, R G Hill

    16. Pharmaceutical developmentT Lundqvist, S Bredenberg

    17. Clinical Development - Present and Future 

    C Keywood

    18. Clinical imaging in drug development 

    P M Matthews

    19. Intellectual property in drug discovery and development 

    P Grubb

    20. Regulatory affairs 

    I Hägglöf, Å Holmgren

    21. Marketing the drug 

    V L Lawton

    SECTION 4

    FACTS AND FIGURES

    22. Drug discovery and development - facts and figures 

    H P Rang, R G Hill

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