Store-Operated Calcium Channels

Store-operated calcium channels are found in most animal cells and regulate many cellular functions including cell division, growth, differentiation, and cell death. This volume provides a concise and informative overview of the principles of store-operated calcium entry and the key developments in the field from researchers who have led these advances. The overall goal of the volume is to provide interested students and investigators with sufficient information to enable a broad understanding of the progress and current excitement in the field. The volume contains a wealth of information that even experienced investigators in the field will find useful.
View full description


Scientists and researchers in biochemistry and molecular and cellular biology


Book information

  • Published: August 2013
  • ISBN: 978-0-12-407870-3

Table of Contents

  1. Store-operated Orai channels: structure and function
    Murali Prakriya
  2. STIM-Orai Interactions that Control the CRAC Channel
    Aparna Gudlur, Yubin Zhou and Patrick G. Hogan
  3. Structure and Function of Endoplasmic Reticulum STIM Calcium Sensors
    Peter B. Stathopulos and Mitsuhiko Ikura
  4. On the Stoichiometry of Resting and Activated CRAC Channels
    Liangyi Chen and Tao Xu
  5. Alternative forms of the Store-operated Calcium Entry Mediators, STIM1 and Orai1
    James W. Putney
  6. The ARC Channel - An Endogenous Store-independent Orai Channel
    Jill L. Thompson, Olivier Mignen, and Trevor J. Shuttleworth
  7. Contribution and Regulation of TRPC Channels in Store-Operated Ca2+ Entry
    Kwong Tai Cheng, Hwei Ling Ong, Xibao Liu, and Indu S. Ambudkar
  8. Molecular Regulation of the Pore Component of CRAC Channels, Orai1
    Sonal Srikanth and Yousang Gwack
  9. Emerging Roles for Native Orai Ca2+ Channels in Cardiovascular Disease
    Brian Ruhle and Mohamed Trebak
  10. The Neglected CRAC Proteins: Orai2, Orai3 and STIM2
    Markus Hoth and Barbara A. Niemeyer