Biochemical Basis of Functional Neuroteratology

Edited by

  • G.J. Boer
  • M.G.P. Feenstra
  • M. Mirmiran
  • D.F. Swaab
  • F. van Haaren

Volume 73 contains papers discussed at the 15th Summer School for Brain Research held in Amsterdam, The Netherlands; the intention of which was to present high level didactic reviews of important lines of investigation in the "neurochemistry of functional neuroteratology; permanent effects of chemical on the developing brain". This topic was chosen to broaden our understanding of an increasingly important branch of brain research generally called "behavioural teratology". Rather than focussing on gross abnormalities in development as encountered in classical teratology, this field concentrates on the subtle, but long-lasting, changes found in the brain due to deleterious chemical and environmental factors experienced during neurogenesis and maturation.
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Book information

  • Published: July 1988
  • Imprint: ELSEVIER
  • ISBN: 978-0-444-80970-4

Table of Contents

Section 1 - Outlines of Functional Neuroteratology. 1. Concept of functional neuroteratology and the importance of neurochemistry (D.F. Swaab, G.J. Boer and M.G.P. Feenstra). 2. Defects of neuronal migration and the pathogenesis of cortical malformation (P. Rakic). 3. Implications of behavioral teratology for assessing the risks posed by environmental and therapeutic chemicals (B. Weiss). 4. Problems in studying functional teratogenicity in man (H.J. Huisjes). 5. Behavioural teratology of exogenous substances: regulation aspects (H.B.W.M. Koëter). Section 2 - Lasting Effects of Early Hormone Imbalance. 6. Teratogenic mechanisms of dysthyroidism in the central nervous system (A. Vaccari). 7. The role of the insulin-like growth factors in the regulation of brain development (V.R. Sara and C. Carlsson-Skwirut). 8. Stress, glucocorticoids and development (E.R. De Kloet, P. Rosenfeld, J.A.M. Van Eeekelen, W. Sutanto and S. Levine). 9. Actions of sex hormones on the brain: "organization" and "activation" in relation to functional teratology (B.S. McEwen). Section 3 - Neuroactive Drugs as Functional Teratogen. 10. Prenatal adverse effects of nicotine on the developing brain (W. Lichtensteiger, U. Ribary, M. Schlumpf, B. Odermatt and H.R. Widmer). 11. Functional deprivation of noradrenaline neurotransmission: effects of clonidine on brain development (M. Mirmiran, M.G.P. Feenstra, F.A. Dijcks, N.P.A. Bos and F. Van Haaren). 12. Long-lasting changes after perinatal exposure to antidepressants (J. Del Rio, D. Montero and M.L. De Ceballos). 13. Placental and blood element neurotransmitter receptor regulation in humans: potential models for studying neurochemical mechanisms underlying behavioral teratology (B.D. Perry). 14. Benzodiazepines: influence on the developing brain (C.K. Kellogg). 15. Anticonvulsants and brain development (C.V. Vorhees, D.R. Minck and H.K. Berry). 16. Neuropeptides and functional neuroteratology (G.J. Boer, F.G.M. Snijdewint and D.F. Swaab). 17. Perinatal exposure to methadone: how do early biochemical alterations cause neurofunctional disturbances? (T.A. Slotkin). Section 4 - Food and Environmental Factors. 18. Excitotoxic food additives: functional teratological aspects (J.W. Olney). 19. Organometals and brain development (Z. Annau). Alcohol as a social teratogen (B.E. Leonard). 21. Prenatal stress effects on functional development of the offspring (M. Weinstock, E. Fride and R. Hertzberg). Section 5 - Neurochemical Mechanisms. 22. Structural-functional relationships in experimentally-induced brain damage (P.M. Rodier). 23. Coordination of cell development by the ornithine decarbozylase (ODC) polyamine pathway as an underlying mechanism in developmental neurotoxic events (J.M. Bell and T.A. Slotkin). 24. Neurotransmitters as morphogens (J.M. Lauder). 25. Brain cell acquisition and neurotropic drugs with special reference to functional teratogenesis (A.J. Patel and P.D. Lewis). 26. Reorganization of noradrenergic neuronal systems following neonatal chemical and surgical injury (R.M. Kostrzewa). 27. Use of toxins to disrupt neurotransmitters circuitry in the developing brain (M.V. Johnston, J. Barks, T. Greenamyre and F. Silverstein). 28. Metabolic imbalance and nerve cell damage in the brain (R. Balázs). 29. Humoral and surface-anchored factors in development and repair of the nervous system (S. Varon, B. Pettman and M. Manthorpe). 30. Gangliosides as cell adhesion factors in the formation of selective connections within the nervous system (R.E. Baker). 31. Prenatal neurotransmitter programming of postnatal receptor function (J.C. Miller and A.J. Friedhoff). 32. Neuropeptide influences on the development of their receptors (G.E. Handelmann). 33. Transgenerational effects of drug and hormonal treatments in mammals: a review of observations and ideas (J.H. Campbell and P. Perkins). Acknowledgements. List of Contributors.