Autoantibodies book cover


Autoantibodies was published and presented in November 2006 at the International Congress of Autoimmunity in Sorrento, a small town in Campania, Italy. The Congress also celebrated the 100th anniversary of the first routine test for autoantibodies. An autoantibody is a type of antibody that is produced by the immune system and that fights one or more of a person’s own proteins. These autoantibodies cause autoimmune diseases such as lupus erythematosus. The authors and editors of this book provide a critical review of autoantibodies and their primary functions. They cite a number of major developments in the field of autoantibodies, including the detection of autoantibodies in which a healthy person is a carrier; the discovery that autoantibodies can be both pathogenic and protective in some cases; and the development of a device that will help monitor and detect a specific autoantibody using a small amount of serum and proteomic arrays. Aside from the pathogenic and protective autoantibodies, the book also discusses irrelevant autoantibodies, as these may be relevant for future research. It also addresses the importance of the autoantibodies in a person’s body. Clinical physicians, as well as scientists interested in the significance of autoantibodies in the human body, will find this book relevant. It will also be of interest to those who suffer from an autoimmune disease.

Physicians and students in Internal Medicine, Rheumatology, Clinical Immunology, Hematology, Endocrinology, Gastroenterology, Neurology, Nephrology, and Dermatology. Also of interest to those working in companies involved in selling diagnostic assays for autoimmune disorders.


Published: November 2006

Imprint: Elsevier

ISBN: 978-0-444-52763-9


  • Foreword

    Autoantibodies: History and Horizons


    About the Editors

    List of Contributors


    I Introduction: Autoantibodies-Unique Characteristics

    1 What is an Autoantibody?

    2 Natural Autoantibodies, Heralding, Protecting and Inducing Autoimmunity

    3 Molecular Mimicry

    4 Affinity and Avidity of Autoantibodies

    5 Pathogenic Mechanisms and Clinical Relevance of Autoantibodies

    6 Native Autoantigens Versus Recombinant Autoantigens

    7 Redox-Reactive Autoantibodies

    8 Predictive Autoantibodies

    9 Autoantibody Subclasses

    10 Idiotypes and Anti-Idiotypes

    11 Novel Diagnostic Methods for Autoantibody Detection

    II Allergic Disease Autoantibodies

    12 Human IgE-Specific Autoantibodies and Autoantibodies to IGE Receptors

    III Antineutrophil Antibodies

    13 Antineutrophil Cytoplasmic Autoantibodies with Specificity for Myeloperoxidase

    14 Antineutrophil Cytoplasmic Autoantibodies with Specificity for Proteinase 3

    15 Neutrophil-Specific Antinuclear and Anti-cytoplasmic Antibodies in Chronic Inflammatory Diseases

    16 Antineutrophil Cytoplasmatic Autoantibodies with Specificity to Proteinase 3

    IV Introduction: Antinuclear Antibodies

    17 Antinuclear Antibodies: General Introduction

    18 Antinucleolar Antibodies

    19 Anti-Chromatin (Nucleosome) Autoantibodies

    20 Centromere Autoantibodies

    21 dsDNA Autoantibodies

    22 Histone Autoantibodies

    23 Ku and Ki Autoantibodies

    24 Neuronal Nuclear Autoantibodies, Type 1 (HU)

    25 Nuclear Envelope Protein Autoantibodies/Antilamin Autoantibodies

    26 Anti-Nucleosome Autoantibodies

    27 Proliferating Cell Nuclear Antigen Autoantibodies

    28 Anti-RA33 Antibodies (Antibodies to the Heterogeneous Nuclear Ribonucleoprotein A2)

    29 Anti-Ribosomal P Antibodies

    30 SS-A (Ro) Autoantibodies

    31 Topoisomerase-I (Scl-70) Autoantibodies

    32 SS-B (La) Autoantibodies

    33 Anti-RNA Polymerase III Antibodies

    V Autoantibodies to Biologic Factors/Structures

    34 GW Bodies, P Bodies and Components of the miRNA Pathway

    35 Golgi Complex and Endosome Antibodies

    36 p53 Autoantibodies

    37 Human Antiganglioside Autoantibodies

    38 Human Anti--Galactosyl Antibodies

    39 Autoantibodies in Therapeutic Preparations of Human Intravenous Immunoglobulin (IVIG)

    40 Cytokine Antibodies

    41 Cytoskeletal Autoantibodies/Anti-Actin Antibodies

    42 Fibrillarin Autoantibodies

    43 Fibronectin Autoantibodies

    44 Interferon-Inducible Protein IFI16 Autoantibodies

    VI Cardiac Autoantibodies

    45 Autoantibodies in Atherosclerosis

    46 Heat Shock Protein Autoantibodies

    47 Myocardial Autoantibodies and their Clinical Significance

    VII Endocrine Autoantibodies

    48 Glutamic Acid Decarboxylase Autoantibodies

    49 Humoral Immunity in Type 1 Diabetes Mellitus

    50 Antibodies to Adrenal, Gonadal Tissues and Steroidogenic Enzymes

    51 Thyroglobulin, Thyroperoxidase, and Thyrotropin-Receptor Autoantibodies

    VIII GI And Liver Autoantibodies

    52 Anti-Intestinal Goblet Cell Antibodies

    53 Tumor-Associated Autoantibodies

    54 Cryoglobulins and Cryoglobulins Secondary to Hepatitis C Virus Infection

    55 Anti-Tissue Transglutaminase and Anti-Endomyisial Antibodies

    56 Anti-Gliadin Antibodies

    57 Reticulin Autoantibodies

    58 Liver Cytosol Antigen Type 1 Autoantibodies, Liver Kidney Microsomal Autoantibodies, and Liver Microsomal Autoantibodies

    59 Antimitochondrial Antibodies

    60 Parietal Cell and Intrinsic Factor Autoantibodies

    61 Smooth Muscle Antibodies

    IX Hematologic Autoantibodies

    62 Coagulation Factor Autoantibodies

    63 Autoantibodies in Heparin-Induced Thrombocytopenia

    64 Platelet Autoantibodies

    65 Red Cell Autoantibodies

    66 Lymphocytotoxic Autoantibodies

    X Kidney Autoantibodies

    67 Anti-ATP Synthase β-Chain Autoantibodies

    68 Glomerular Basement Membrane Autoantibodies

    69 Nephritic Factor Autoantibodies

    XI Neurological System Autoantibodies

    70 Acetylcholine Receptor and Muscle Specific Kinase Autoantibodies

    71 Myositis Autoantibodies: Aminoacyl-tRNA Synthetase, Signal Recognition Particle, Mi-2, and PM-Scl Autoantibodies

    72 Anti-MOG Antibodies

    73 Antibodies to Hsp 70 in Inner Ear Disease

    74 Autoantibodies in the Lambert-Eaton Myasthenic Syndrome (LEMS) and Amyotrophic Lateral Sclerosis (ALS)

    75 Ganglioside Autoantibodies

    76 Myelin Associated Antibodies: Myelin-Associated Glycoprotein Autoantibodies, Myelin Basic Protein Autoantibodies and Myelin Proteolipid Autoantibodies in Neurologic Diseases

    77 Paraneoplastic Neurological Antibodies: Nuclear

    78 Paraneoplastic Neurological Antibodies: Purkinje Cell Cytoplasm

    79 Paraneoplastic Neurological Antibodies: Additional Reactivities

    80 Retinal Autoantibodies

    81 Autoantibodies in Epilepsy

    XII Rheumatic Disease Autoantibodies

    82 Anti-Fodrin Antibodies

    83 Antibodies to Laminin

    84 Autoantibodies Against Muscarinic Acetylcholine Receptor in Patients with Sjögren’s Syndrome

    85 β2-Glycoprotein I Autoantibodies

    86 C1 Inhibitor Autoantibodies

    87 Autoantibodies to C1q

    88 Anti-Collagen Antibodies

    89 Anti-Cyclic Citrullinated Peptide Antibody

    90 Anti-Endothelial Cell Autoantibodies

    91 Lupus Anticoagulant Testing

    92 Anticardiolipin Antibodies

    93 Phospholipid Autoantibodies (Non-Anticardiolipin)-Anti-Prothrombin Antibodies

    94 Rheumatoid Factors

    XIII Skin Disease Autoantibodies

    95 Autoantibodies to Mucocutaneous Antigens

    XIV Unique Clinical Situations

    96 Autoimmunity and the Newer Biopharmaceuticals

    97 Autoantibodies Against Tumor Suppressor Proteins

    98 Detection of Autoantibodies Using Protein Arrays

    99 Autoantibodies and Pregnancy Loss

    XV Future Directions

    100 Anti-Glycan Antibodies

    101 Future Trends



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