Asthma and COPD

Basic Mechanisms and Clinical Management

Edited by

  • Peter Barnes, DM FRS FMedSci, Head of Respiratory Medicine, Imperial College, London, UK, Airway Disease Section, National Heart and Lung Institute
  • Jeffrey Drazen, Brigham and Women's Hospital, Boston, MA, USA
  • Stephen Rennard, University of Nebraska Medical Center, Omaha, USA
  • Neil Thomson, Western Infirmary, Glasgow, Scotland

The Second Edition of Asthma and COPD: Basic Mechanisms and Clinical Management continues to provide a unique and authoritative comparison of asthma and COPD. Written and edited by the world's leading experts, it continues to be a comprehensive review of the most recent understanding of the basic mechanisms of both conditions, specifically comparing their etiology, pathogenesis, and treatments.
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Cell biologists, immunologists, pharmacologists and physicians working in pulmonary research in academia or the pharmaceutical industry


Book information

  • Published: October 2008
  • ISBN: 978-0-12-374001-4


"...textbooks, such as the one discussed here, are all essential in shaping a necessary way forward to fight chronic respiratory diseases worldwide...At first it was a surprise to see that this impressive textbook covered both asthma and chronic obstructive pulmonary disease (COPD) in one volume. Asthma and COPD: Basic Mechanisms and Clinical Management is edited and written by prominent individuals who have done everything possible in the past to convey the message that asthma and COPD are two different diseases: that they are characterised by different risk factors; have a different pathophysiology; are characterised by clinical phenotypes that are distinctly different; require different therapeutic strategies; and probably pose very different challenges to the health-care system. Yet in this textbook they now provide a truly novel approach towards our understanding and perception of asthma and COPD...the combined approach set out in this book towards asthma and COPD is not so much the Dutch hypothesis revisited, rather it is a more than sensible approach to understanding the nature and the challenges of chronic respiratory diseases in general.
Asthma and COPD provides a superb synthesis of the most up-to-date knowledge on obstructive airways diseases by leading experts in the field...The description of basic mechanisms is a particularly strong feature, but the reader also finds excellent chapters on the pathogenic mechanisms of asthma and COPD, a description of risk factors and triggers, and a clinically useful description of the clinical assessment of these frequent conditions...this textbook is a joy to browse through and to read; it is very well illustrated, and the tabulated material is truly educational...I hope that this book will become one of the major reference sources for information on asthma and COPD and that it might have the potential to serve a much wider medical community than respiratory textbooks usually do."
--Klaus F. Rabe, The Lancet

Table of Contents

1 Definitions, Epidemiology and Genetics of Asthma and COPD2 Epidemiology3 Natural History4 Genetics of Asthma and COPD5 Pulmonary Physiology6 Airway Pathology 7 Airway Remodeling8 Animal Models9 Mast Cells and Basophils10 Dentritic Cells11 Macrophages12 Eosinophils13 Lymphocytes14 Neutrophils15 Fibroblasts16 Epithelial Cells17 Mucus and Mucin-Secreting Cells18 Airway Smooth Muscle19 Tracheobronchial Circulation20 Pulmonary Vessels21 Adhesion Molecules 22 Extracellular Matrix23 Prostanoids24 Leukotrienes and Lipoxins25 Reactive Oxygen Species 26 Chemokines27 Cytokines28 Matrix Degrading Proteinases29 Growth Factors, 30 Nitric Oxide31 Transcription Factors32 Neural and Humoral Control33 Pathophysiology of Asthma34 Pathogenesis of COPD35 Allergens36 Occupational Agents37 Infections38 Exercise as a Stimulus39 Atmospheric Pollutants40 Drugs41 Diagnosis42 Non-invasive Assessment of Airway Inflammation43 Imaging44 Systemic Manifestations45 Cardiovascular Effects46 Allergen Avoidance47 Smoking Cessation48 â2-adrenoceptor Agonists49 Anticholinergic Bronchodilators50 Theophylline51 Corticosteroids52 Mediator Antagonists53 Antibiotics54 Long-term Oxygen Therapy55 Immunomodulators56 Pulmonary Vasodilators57 Ventilator Support58 Pulmonary Rehabilitation59 Surgery and Other Mechanical Interventions60 Other Therapies61 Future Therapies62 Health Economics63 Management of Chronic Asthma in Adults64 Asthma Exacerbations65 Childhood Asthma66 Treatment for Stable COPD67 Acute Exacerbations of COPD68 Education and Self-Management