Antioxidant and Redox Regulation of Genes

Edited by

  • Chandan Sen, The Ohio State University, Wexner Medical Center, Columbus, Ohio, USA
  • Lester Packer, Department of Molecular Pharmacology and Toxicology, School of Pharmaceutical Sciences, University of Southern California, USA
  • Patrick Baeuerle, Micromet GmbH, Martinsried, Germany

This volume addresses oxidant-reduction or redox and antioxidant sensitive molecular mechanisms and how they are implicated in different disease processes. Possible strategies to pharmacologically and/or nutritionally manipulate such redox-sensitive molecular responses are emphasized.
View full description


Clinical researchers, molecular biologists, geneticists, pharmacologists, nutritionists, physiologists, biomedical researchers, and gerontologists.


Book information

  • Published: October 1999
  • ISBN: 978-0-12-636670-9

Table of Contents

Reactive Species as Intracellular Messengers:L.-O. Klotz, K. Briviba, and H. Sies, Signalling by Singlet Oxygen in Biological Systems.D.R. Crawford, T. Suzuki, and K.J.A. Davies, Oxidant-modulated Gene Expression.H.H. Hassanain and P.J. Goldschmidt-Clermont, RAC, Superoxide, and Signal Transduction.S.K. Koliwad, A.K. Brzezinska, and S.J. Elliott, Redox Regulation of Ion Channels.J. Giron-Calle and H.J. Forman, Cell Ca2+ in Signal Transduction: Modulation in Oxidative Stress.G.L. Schieven, Introduction of Protein Tyrosine Phosphorylation by Oxidative Stress and its Implications.A.A. Deora and H.M. Lander, Regulation of Signal Transduction and Gene Expression by Reactive Nitrogen Species.Redox Sensitive Molecular Processes and Cellular Responses:P.A. Baeuerle, Reactive Oxygen Species as Costimulatory Signals of Cytokine-Induced NFkappaB Activation Pathways.T. Okamoto, T. Tetsuka, and T. Kawabe, Redox Regulation of Nuclear Factor kappa B.C.K. Sen, Oxidants and Antioxidants in Aptosis: Role of Bcl-2.V. Goossens, K. De Vos, D. Vercammen, M. Steemans, K. Vancompernolle, W. Fiers, P. Vandenabeele, and J. Grooten, Role of Reactive Oxygen Species in TNF Toxicity.S. Roy, C.K. Sen, A. Gozin, V. Andrieu, and C. Pasquier, Redox Regulation of Cell Adhesion Processes.H. Masutani, M. Ueno, S. Ueda, and J. Yodoi, Role of Thioredoxin and Redox Regulation in Oxidative Stress Response and Signalling.A.H. Schönthal, S. Mueller, and E. Cadenas, Redox Regulation of p21, Role of Reactive Oxygen and Nitrogen Species in Cell Cycle Progression.Clinical Implications of Redox Signaling and Antioxidant Therapy:H. Viita and S. Ylä-Hertuala, Effect of Lipoxygenases on Gene Expression in Mammalian Cells.A. Azzi, Tocopherol in the Pathogenesis of Atherosclerosis: One Molecule, Several Functions.D.-Y. Jin and K.-T. Jeang, Peroxiredoxins in Cell Signaling and HIV Infection.J.S. Bertram, T. King, L. Fukishima, and F. Khachik, Enhanced Activity of an Oxidation Product of Lycopene Found in Tomato Products and Human Serum Relevant to Cancer Prevention.C. Bladier, J.B. de Haan, and I. Kola, Antioxidant Genes and Reactive Oxygen Species in Down's Syndrome.B.S. Kristal and B.P. Yu, Oxidant-mediated Repression of mtDNA Transcription.Y. Kajimoto, Y. Yamasaki, T. Matsuoka, H. Kaneto, and M. Hori, Suppression of the Insulin Gene Promoter Activity by Oxidative Stress.N. Maulik and D.K. Das, Redox Regulation of Ischemic Adaptation.W.C. Orr and R.S. Sohal, Oxidative Stress as a Governing Factor in Physiological Aging.W. Dröge, V. Hack, R. Breitkreutz, E. Holm, S. Holm, and R. Kinscherf, Antioxidants in Senescence and Wasting.Subject Index.