Antibody Fc: book cover

Antibody Fc:

Linking Adaptive and Innate Immunity

Antibody Fc is the first single text to synthesize the literature on the mechanisms underlying the dramatic variability of antibodies to influence the immune response. The book demonstrates the importance of the Fc domain, including protective mechanisms, effector cell types, genetic data, and variability in Fc domain function. This volume is a critical single-source reference for researchers in vaccine discovery, immunologists, microbiologists, oncologists and protein engineers as well as graduate students in immunology and vaccinology.

Antibodies represent the correlate of protection for numerous vaccines and are the most rapidly growing class of drugs, with applications ranging from cancer and infectious disease to autoimmunity. Researchers have long understood the variable domain of antibodies, which are responsible for antigen recognition, and can provide protection by blocking the function of their target antigen. However, recent developments in our understanding of the protection mediated by antibodies have highlighted the critical nature of the antibody constant, or Fc domain, in the biological activity of antibodies. The Fc domain allows antibodies to link the adaptive and innate immune systems, providing specificity to a wide range of innate effector cells. In addition, they provide a feedback loop to regulate the character of the immune response via interactions with B cells and antigen-presenting cells.


vaccinologists, immunologists, microbiologists, oncologists, protein engineers, in academic and industrial research institutions; graduate students in immunology and vaccinology.

Hardbound, 358 Pages

Published: September 2013

Imprint: Academic Press

ISBN: 978-0-12-394802-1


  • Part 1: Effector Mechanisms
    Ch 1: Antibody Dependent Cellular Cytotoxicity
    Ch 2: Antibody-Dependent Cellular Phagocytosis and its Impact on Pathogen Control
    Ch 3: Interactions between the Complement System and Fcy Receptors

    Part 2: Effector Cells
    Ch 4: Natural Killer Cells
    Ch 5: Phagocytes and Immunoglobulins
    Ch 6: B Cells

    Part 3: FcR
    Ch 7: Structural Recognition of Immunoglobulins by Fcg Receptors
    Ch 8: FcyRs Across Species
    Part 4: Variability of the Fc Domain
    Ch 9: Human IgG Subclasses
    Ch 10: Antibody Glycosylation

    Part 5: Genetic Associations
    Ch 11: Activating and Inhibitory FcyRs in Autoimmune Disorders
    Ch 12: Fcg Receptor Polymorphisms and Susceptibility to Infection
    Ch 13: Role of IgG Fc Receptors in Monoclonal Antibody Therapy of Cancer

    Part 6: Evolving areas
    Ch 14: Interactions Among Monoclonal Antibody Mechanisms of Action
    Ch 15: Fc Receptor-Dependent Immunity
    Ch 16: Fcy Receptors as Therapeutic Targets
    Ch 17: Fc Protein Engineering
    Ch 18: Bacterial Modulation of Fc Effector Functions
    Ch 19: Pathogenic Exploitation of Fc Activity
    Ch 20: Mechanisms of Immunoglobulin-Mediated Mucus Entrapment of Pathogens at Various Mucosal Surfaces


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