Annotating New Genes

From in Silico Screening to Experimental Validation


  • Shizuka Uchida, Max-Planck-Institute, Germany

In recent years, a number of academic and commercial software packages and databases have been developed for the analysis and screening of biological data; however, the usability of these data is compromised by so-called novel genes to which no biological function is assigned. Annotating new genes outlines an approach to the analysis of evolutionary-conserved, heart-enriched genes with unknown functions, offering a step-by-step description of the procedure from screening to validation. The book begins by offering an introduction to the databases and software available, before moving on to cover programming guidelines, including a specific case study on the use of C-It for in silico screening. The second half of the book offers a step-by-step guide to experimental validation concepts and procedures, as well as an overview of additional potential applications of this approach in the field of stem cells and tissue regeneration, before a concluding chapter summarises the concepts and theories presented.
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Academics and researchers in the field of bioinformatics and developmental biology; Geneticists and biologists


Book information

  • Published: August 2012
  • Imprint: Woodhead Publishing
  • ISBN: 978-1-907568-68-8

Table of Contents

Databases and software to make your research life easier; How to program like a bioinformatician? Case study: C-It, knowledge database for screening evolutionarily conserved, tissue-enriched, uncharacterized genes; Experimental validation: Concepts and practice; Further application: Adult stem cells and tissue regenerations; Conclusion.