Thanh Nguyen

Dr. Nguyen is an associate professor of Mechanical Engineering, joined with the Biomedical Engineering department at the University of Connecticut (UConn). His research is highly interdisciplinary and at the interface of biomedicine, materials and nano/micro technology. Specifically, his research focuses on the science and technology to transform biodegradable and biocompatible materials (e.g surgical-suture polymers and amino acids) into special forms, shapes, or structures with “smart” functions at nano/micro-scales for diverse applications in vaccine/drug delivery, regenerative engineering and electrical implants. He developed a platform technology, so-called SEAL (StampEd Assembly of polymer Layer) to create 3-dimensional microstructures of biodegradable polymers and advanced the SEAL method to create a novel single-administration self-boosting skin microneedle patch for vaccines and other therapeutics, avoiding all painful and inconvenient injections in the traditional vaccine/drug administration methods. Besides, his research group at UConn has extensively studied biodegradable piezoelectric materials, derived from safe medical polymers and natural amino acids, to develop novel biodegradable implanted force-sensor and ultrasound transducer for monitoring vital intra-organ pressures and delivering medicines through the blood-brain barrier, respectively. The biodegradable piezoelectric materials were also used as a tissue scaffold which can be remotely activated to produce electrical cues for stimulating tissue regeneration. Dr. Nguyen’s works have been published in prestigious journals including Science, Science Translational medicine, Nature Nanotechnology, Nature Communication, Advanced Materials, PNAS etc. and highlighted in major media such as The New York Times, BBC News, the Guardian, NIH research matter etc. He was elected as the senior member of National Academy of Inventor - NAI (2024). He is the associate editor of the journal of Biomaterials and serving as a standing review member for National Institute of Health (NIH). He received several awards/honors including the MRS Early Distinguished Invited Speaker (2025), Young Investigator Award from the journal of Biomaterials (2022), ACell Young Investigator Award (2020), MIT top innovator under 35 for Asia Pacific (2019), NIH Trailblazer Award for Young and Early Investigators (2018), SPIE Rising Researcher Award (2019), Young Investigator Award in Biosciences and Bioengineering of Applied Sciences (2019), and the SME Outstanding Young Manufacturing Engineer Award (2018) etc.