Providing Pharmacological Access to the Brain

Alternate Approaches

1st Edition, Volume 21 - September 16, 1994

Editors: Thomas R. Flanagan, P. Michael Conn, Dwaine F. Emerich, Shelley R. Winn

eBook ISBN:

9 7 8 - 1 - 4 8 3 2 - 8 8 3 5 - 2

This volume focuses on contemporary approaches for delivering experimental and therapeutic agents into the brain. The contributions provide methodological details that are… Read more

Providing Pharmacological Access to the Brain

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This volume focuses on contemporary approaches for delivering experimental and therapeutic agents into the brain. The contributions provide methodological details that are typically not available in the literature. Subtleties and shortcuts critical to each procedure are included to facilitate their use by both the experienced researcher and novice.

Characterizing the Blood-Brain Barrier:
A. Logan and M. Berry, Cellular Response of Central Nervous System Tissue to Invasive Therapeutic Measures.
J.M. Rosenstein and J.M. Krum, Models of Angiogenesis and the Blood-Brain Barrier.
Transiently Removing the Blood-Brain Barrier:
P.J. Robinson, Osmotic Opening of the Blood-Brain Barrier and Brain Tumor Chemotherapy.
E.A. Neuwelt and R.A. Kroll, Osmotic Blood-Brain Barrier Modification: Increasing Delivery of Diagnostic and Therapeutic Agents to the Brain.
Facilitated Transport through the Blood-Brain Barrier:
A.-C. Granholm, P.T. Biddle, C. Bäckman, T. Ebendal, G. Gerhardt, B. Hoffer, L. Mackerlova, L. Olson, S. Söderström, L. Walus, and P. Friden, Peripheral Administration of Nerve Growth Factor Conjugated to an Anti-transferrin Receptor Antibody Increases Cholinergic Neuron Survival in Intraocular Forebrain Transplants.
R.D. Broadwell, B.J. Baker, W.A. Banks, P. Friden, M. Moran,C. Oliver, and J.C. Villegas, Ferrotransferrin and Antibody against the Transferrin Receptor as Potential Vehicles for Drug Delivery across the Mammalian Blood-Brain-Barrier into the Central Nervous System.
S. Kim, Depofoam-Mediated Drug Delivery into Cerebrospinal Fluid. Polymeric Release Systems for the Central Nervous System:
R.J. Tamargo, R. Langer, and H. Brem, Interstitial Drug Delivery to the Central Nervous System Using Controlled Release Polymers: Chemotherapy for Brain Tumors.
A. Mendez, P.J. Camarata, R. Suryanarayanan, and T.J. Ebner, Sustained Intracerebral Delivery of Nerve Growth Factor with Biodegradable Polymer Microspheres.
A.J. Domb and I. Ringel, Polymeric Drug Carrier Systems in the Brain.
Using Pump Delivery Devices within the Brain:
J.D. White and M.W. Schwartz, Using Osmotic Minipumps for Intracranial Delivery of Amino Acids and Peptides.
T. Hagg, Continuous Central Nervous System Infusion with Alzet Osmotic Pumps.
P.M. Carvey,T.J. Maag, and D. Lin, Injection of Biologically Active Substances into the Brain.
Using Implanted Living Tissues within the Brain:
R. Barker, R. Fricker, and S.B. Dunnett, Factors Important in the Survival of Dopamine Neurons in Intracerebral Grafts of Embryonic Substantia Nigra.
M.S. Fiandaca and J.H. Kordower, Techniques in Adrenal Medullary Transplantation for Experimental Nonhuman Primate Parkinsonism.
S.W. Carmichael, S.L. Stoddard, and P.J. Kelly, Technical Aspects of Transplantation of the Adrenal Medulla to the Caudate Nucleus as a Treatment for Parkinsons Disease.
Creating Cell Lines for Transplant Therapies:
J.P. Hammang, B.A. Reynolds, S. Weiss, A. Messing, and I.D. Duncan, Transplantation of Epidermal Growth Factor-Responsive Neural Stem Cell Progeny into the Murine Central Nervous System.
J.P. Kesslak and R.J. Bridges, Application of Astrocyte Transplants as a Therapeutic Intervention.
M. Giordano, H. Takashima, M. Poltorak, H.M. Geller, and W.J. Freed, Development of Immortalized Cell Lines for Transplantation in Central Nervous System Injury and Degeneration Models.
Using Implanted Living Cells within the Central Nervous System:
L.J. Fisher, G.R. Chalmers, and F.H. Gage, Use of Genetically Modified Cells to Deliver Neurotrophic Factors and Neurotransmitters to the Brain.
J. Sagen, J.D. Ortega, and G.D. Pappas, Neuropeptide and Catecholamine Delivery to the Central Nervous System by Implanted Chromaffin Cells.
Using Implanted Encapsulated Cells within the Brain:
M.V. Sefton, H. Uludag, J. Babensee, T. Roberts, V. Horvath, and U. De Boni, Microencapsulation of Cells in Thermoplastic Copolymer (Hydroxyethyl Methacrylate-Methyl Methacrylate).
S.R. Winn and P.A. Tresco, Hydrogel Applications for Encapsulated Cellular Transplants.
T.R. Flanagan, B. Frydel, B. Tente, M. Lavoie, E. Doherty, D. Rein, D.F. Emerich, and S.R. Winn, Test for Validating the Safety of Encapsulated Xenografts.
Induced Gene Expression in Intrinsic Central Nervous System Cells with DNA Injected into the Brain:
N.-S. Yang, S. Jiao, and C. De Luna, Particle Bombardment for Gene Transfer into Nerve Cell Systems.
Viral Transfection of Intrinsic Cells within the Brain:
A.I. Geller, M.J. During, and R. Neve, A Defective Herpes Simplex Virus Vector System for Genetic Intervention in the Adult Brain: Applications to Gene Therapy and Neuronal Physiology.
M.D. Geschwind, B. Lu, and H. Federoff, Expression of Neurotropic Factor Genes from Herpes Simplex Virus Type 1 Vectors: Modifying Neuronal Phenotype.
Predicting the Future of Central Nervous System Delivery System Technologies:
J.S. Swen, T.R. Flanagan, and T.G. Wiggans, Assessing the Commercial Potential of Central Nervous System Delivery Approaches.
Index.

Thomas R. Flanagan

Affiliations and expertise

Chatham Associates, Barrington, Rhode Island, U.S.A.

P. Michael Conn

P. Michael Conn is the Senior Vice President for Research and Associate Provost, Texas Tech Health Sciences Center. He is The Robert C. Kimbrough, Professor of Internal Medicine and Cell Biology/Biochemistry. He was previously Director of Research Advocacy and Professor of Physiology and Pharmacology, Cell Biology and Development and Obstetrics and Gynecology at Oregon Health and Science University and Senior Scientist of the Oregon National Primate Research Center (ONPRC). He served for twelve years as Special Assistant to the President and Associate Director of the ONPRC. After receiving a B.S. degree and teaching certification from the University of Michigan (1971), a M.S. from North Carolina State University (1973), and a Ph.D. degree from Baylor College of Medicine (1976), Conn did a fellowship at the NIH, then joined the faculty in the Department of Pharmacology, Duke University Medical Center where he was promoted to Associate Professor in 1982. In 1984, he became Professor and Head of Pharmacology at the University of Iowa College of Medicine, a position he held for eleven years. Conn is known for his research in the area of the cellular and molecular basis of action of gonadotropin releasing hormone action in the pituitary and therapeutic approaches that restore misfolded proteins to function. His work has led to drugs that have benefitted humans and animals. Most recently, he has identified a new class of drugs, pharmacoperones, which act by regulating the intracellular trafficking of receptors, enzymes and ion channels. He has authored or co-authored over 350 publications in this area and written or edited over 200 books, including texts in neurosciences, molecular biology and endocrinology. Conn has served as the editor of many professional journals and book series (Endocrinology, Journal of Clinical Endocrinology and Metabolism, Endocrine, Methods, Progress in Molecular Biology and Translational Science and Contemporary Endocrinology). Conn served on the National Board of Medical Examiners, including two years as chairman of the reproduction and endocrinology committee. The work of his laboratory has been recognized with a MERIT award from the NIH, the J.J. Abel Award of the American Society for Pharmacology and Experimental Therapeutics, the Weitzman, Oppenheimer and Ingbar Awards of the Endocrine Society, the National Science Medal of Mexico (the Miguel Aleman Prize) and the Stevenson Award of Canada. He is the recipient of the Oregon State Award for Discovery, the Media Award of the American College of Neuropsychopharmacology and was named a distinguished Alumnus of Baylor College of Medicine in 2012. Conn is a previous member of Council for the American Society for Cell Biology and the Endocrine Society and is a prior President of the Endocrine Society, during which time he founded the Hormone Foundation and worked with political leadership to heighten the public’s awareness of diabetes. Conn’s students and fellows have gone on to become leaders in industry and academia. He is an elected member of the Mexican Institute of Medicine and a fellow of the American Association for the Advancement of Science. He is the co-author of The Animal Research War (2008) and many articles for the public and academic community on the value of animal research and the dangers posed by animal extremism. His op/eds have appeared in The Washington Post, The LA Times, The Wall Street Journal, the Des Moines Register, and elsewhere. Conn consults with organizations that are influenced by animal extremism and with universities and companies facing challenges from these groups.

Affiliations and expertise

Senior Vice President for Research and Associate Provost, Texas Tech Health Sciences Center, TX, USA

Dwaine F. Emerich

Affiliations and expertise

LCT Biopharma, Providence, Rhode Island, U.S.A.

Shelley R. Winn

Affiliations and expertise

CytoTherapeutics, Providence, Rhode Island, U.S.A.