1. EGFR and HER2 inhibitors as sensitizing agents for cancer chemotherapy
2. BCR-ABL inhibitors as sensitizing agents for cancer chemotherapy
3. VEGFR inhibitors as sensitizing agents for cancer chemotherapy
4. ALK inhibitors as sensitizing agents for cancer chemotherapy
5. JAK2 inhibitors as sensitizing agents for cancer chemotherapy
6. FLT3 inhibitors as sensitizing agents for cancer chemotherapy
7. BRAF inhibitors as sensitizing agents for cancer chemotherapy
8. Bruton kinase inhibitors as sensitizing agents for cancer chemotherapy
Tyrosine Kinase Inhibitors as Sensitizing Agents for Chemotherapy, the fourth volume in the Cancer Sensitizing Agents for Chemotherapy Series, focuses on strategic combination therapies that involve a variety of tyrosine kinase inhibitors working together to overcome multi-drug resistance in cancer cells. The book discusses several tyrosine kinase inhibitors that have been used as sensitizing agents, such as EGFR, BCR-ABL, ALK and BRAF. In each chapter, readers will find comprehensive knowledge on the inhibitor and its action, including its biochemical, genetic, and molecular mechanisms' emphases. This book is a valuable source for oncologists, cancer researchers and those interested in applying new sensitizing agents to their research in clinical practice and in trials.
- Summarizes the sensitizing role of some tyrosine kinase inhibitors in existing research
- Brings recent findings in several cancer types, both experimental and clinically, with a particular emphases on underlying biochemical, genetic, and molecular mechanisms
- Provides an updated and comprehensive knowledge regarding the field of combinational cancer treatment
Cancer researchers; oncologists; pharmacists; graduate students on cancer studies
- No. of pages:
- © Academic Press 2019
- 1st November 2018
- Academic Press
- Hardcover ISBN:
Zhe-Sheng Chen opened the St. John’s University’s first cancer pharmacology laboratory. His research interest is multidrug resistance and its reversal, novel anti-cancer drug development. Chen serves as Editor of "African Journal of Pharmacy and Pharmacology"; Editor-in-Chief of “Journal of Cancer Research Updates" and "Journal of New Developments in Chemistry". He also serves as an Editorial Board member of 25 journals, an Ad Hoc reviewer of 180 journals, and a guest editor of "Current Pharmaceutical Biotechnology", "Cancer" and "Journal of International Medical Research". Chen has over 170 papers published, 6 book chapters, and 5 patents.
Director, Institute for Biotechnology and Professor of Cancer Pharmacology, St. John’s University, USA
Dong-Hua Yang is an Assistant Professor at Fox Chase Cancer Center, where she takes charge of the Tissue Research Service at the Biosample Repository Core Facility. She is a leading expert in the field of immunohistochemistry (IHC) and quantitative analysis. She has applied IHC technology to study the molecular alterations of known and novel signaling pathways that regulate embryogenesis, organ morphogenesis and tumorigenesis. Yang leads the automatic quantitative analysis (AQUA) for immunohistochemistry and immunofluorescence assays for biomarker research. Yang is an active member of the Developmental Therapeutics Program at the Fox Chase Cancer Center with the central goal of developing new agents to treat human cancer by incorporating a broad range of scientists and physicians with research interests ranging from basic science to early phase clinical trials and expertise in structural biology, signal transduction, antibody engineering, preclinical efficacy and clinical development (early phase clinical trials). She is member of the editorial boards of the “Journal of Cancer Research Updates” and the “Journal of Analytical Oncology”; ad hoc reviewer for a number of journals including “Biomarkers”, “Biochemical Pharmacology”, “Current Pharmaceutical Biotechnology”, “Current Proteomics” and “Experimental Neurology”.
Assistant Research Professor of Cancer Pathology, Fox Chase Cancer Center, USA