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Non-Enzymatic Protein Modifications in Health, Disease and Ageing
1st Edition - November 1, 2018
Authors: Izabela Sadowska-Bartosz, Grzegorz Bartosz
Paperback ISBN:
9 7 8 - 0 - 1 2 - 8 1 4 3 0 5 - 6
eBook ISBN:
9 7 8 - 0 - 1 2 - 8 1 4 3 0 6 - 3
Non-Enzymatic Protein Modifications in Health, Diseases and Ageing discusses each type of non-enzymatic protein, introducing non-enzymatic protein modifications, reviewing the… Read more
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Non-Enzymatic Protein Modifications in Health, Diseases and Ageing discusses each type of non-enzymatic protein, introducing non-enzymatic protein modifications, reviewing the state-of-the-art, and presenting updates and current trends. The book covers various aspects of the subject, including the formation and removal of modified proteins, their roles in disease, preventative methods, and possible roles in cellular signaling. This book not only provides well-established facts, but also discusses current hypotheses and controversies.
- Provides the basic chemical knowledge necessary to understand non-enzymatic protein modifications
- Combines a systematic chemical introduction to non-enzymatic protein modifications
- Presents the types of non-enzymatic proteins that are usually separately reported and reviewed
- Considers current hypotheses and controversies alongside the facts
Early-career researchers in biochemistry, biophysics, cell biology, biological chemistry, and food chemistry; Advanced researchers in aligned fields looking to update their knowledge of protein modifications
1. Chemistry of non-enzymatic protein modifications.1.1. Reactive oxygen, nitrogen and halogen species, their formation and chemistry1.2. Reducing sugars in the body and their reactivity with proteins1.3. Formation and reactivity of reactive carbonyls2. Methods for detection and quantification of non-enzymatic protein modifications3. Non-enzymatic protein modifications under physiological conditions3.1. Protein oxidation3.2. Protein glutathionylation 3.3. Protein nitration3.4. Protein nitrosylation3.5. Protein halogenation3.6. Protein glycoxidation3.7. Protein modification by reactive aldehydes3.8. Protein carbamylation3.9. Other protein modifications: deamidation, pyrophosphorylation, beta-elimination, amino acid racemization4. Possible role of non-enzymatic protein modifications in cellular signalling5. Altered non-enzymatic protein modifications in diseases and their pathogenic roles6. Accumulation of products of non-enzymatic protein modification in aging and their potential role in aging7. Prevention of non-enzymatic protein modifications and of their effects7.1. Antioxidants in prevention of non-enzymatic protein modifications7.2. Enzymatic means of prevention of protein modifications7.3. Repair of modified proteins7.4. Removal of modified proteins8. Non-enzymatic protein modifications during food and feed preparation and storage, and their effect on food and feed quality9. Summary: what to expect?
- No. of pages: 252
- Language: English
- Edition: 1
- Published: November 1, 2018
- Imprint: Academic Press
- Paperback ISBN: 9780128143056
- eBook ISBN: 9780128143063
IS
Izabela Sadowska-Bartosz
Izabela Sadowska-Bartosz is Assistant Professor in the Department of Biochemistry and Cell Biology, at the University of Rzeszów in Poland. Her research focusses on non-enzymatic protein modifications, their roles in disease and aging, and their prevention. She has published widely on the topic, and received the title of Dr.habil for her work on ‘Prevention of selected non-enzymatic modifications of proteins by natural and synthetic antioxidants’
Affiliations and expertise
Assistant Professor, Department of Biochemistry and Cell Biology, University of Rzeszow, PolandGB
Grzegorz Bartosz
Grzegorz Bartosz is a Professor and Head of the Molecular and Biophysics Department, and the Department for Membrane Biophysics at the Faculty of Biology and Environmental Protection at the University of Lodz in Poland. He has published widely in the field.
Affiliations and expertise
Professor and Head, Molecular and Biophysics Department, and the Department for Membrane Biophysics, Faculty of Biology and Environmental Protection, University of Lodz, Poland