Non-Enzymatic Protein Modifications in Health, Disease and Ageing - 1st Edition - ISBN: 9780128143056

Non-Enzymatic Protein Modifications in Health, Disease and Ageing

1st Edition

Authors: Izabela Sadowska-Bartosz Grzegorz Bartosz
Paperback ISBN: 9780128143056
Imprint: Academic Press
Published Date: 1st June 2020
Page Count: 252
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Non-Enzymatic Protein Modifications in Health, Diseases and Ageing discusses each type of non-enzymatic protein, introducing non-enzymatic protein modifications, reviewing the state-of-the-art, and presenting updates and current trends. The book covers various aspects of the subject, including the formation and removal of modified proteins, their roles in disease, preventative methods, and possible roles in cellular signaling. This book not only provides well-established facts, but also discusses current hypotheses and controversies.

Key Features

  • Provides the basic chemical knowledge necessary to understand non-enzymatic protein modifications
  • Combines a systematic chemical introduction to non-enzymatic protein modifications
  • Presents the types of non-enzymatic proteins that are usually separately reported and reviewed
  • Considers current hypotheses and controversies alongside the facts


Early-career researchers in biochemistry, biophysics, cell biology, biological chemistry, and food chemistry; Advanced researchers in aligned fields looking to update their knowledge of protein modifications

Table of Contents

1. Chemistry of non-enzymatic protein modifications.
1.1. Reactive oxygen, nitrogen and halogen species, their formation and chemistry
1.2. Reducing sugars in the body and their reactivity with proteins
1.3. Formation and reactivity of reactive carbonyls
2. Methods for detection and quantification of non-enzymatic protein modifications
3. Non-enzymatic protein modifications under physiological conditions
3.1. Protein oxidation
3.2. Protein glutathionylation
3.3. Protein nitration
3.4. Protein nitrosylation
3.5. Protein halogenation
3.6. Protein glycoxidation
3.7. Protein modification by reactive aldehydes
3.8. Protein carbamylation
3.9. Other protein modifications: deamidation, pyrophosphorylation, beta-elimination, amino acid racemization
4. Possible role of non-enzymatic protein modifications in cellular signalling
5. Altered non-enzymatic protein modifications in diseases and their pathogenic roles
6. Accumulation of products of non-enzymatic protein modification in aging and their potential role in aging
7. Prevention of non-enzymatic protein modifications and of their effects
7.1. Antioxidants in prevention of non-enzymatic protein modifications
7.2. Enzymatic means of prevention of protein modifications
7.3. Repair of modified proteins
7.4. Removal of modified proteins
8. Non-enzymatic protein modifications during food and feed preparation and storage, and their effect on food and feed quality
9. Summary: what to expect?


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© Academic Press 2020
Academic Press
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About the Author

Izabela Sadowska-Bartosz

Izabela Sadowska-Bartosz is Assistant Professor in the Department of Biochemistry and Cell Biology, at the University of Rzeszów in Poland. Her research focusses on non-enzymatic protein modifications, their roles in disease and aging, and their prevention. She has published widely on the topic, and received the title of Dr.habil for her work on ‘Prevention of selected non-enzymatic modifications of proteins by natural and synthetic antioxidants’

Affiliations and Expertise

Assistant Professor, Department of Biochemistry and Cell Biology, University of Rzeszow, Poland

Grzegorz Bartosz

Grzegorz Bartosz is a Professor and Head of the Molecular and Biophysics Department, and the Department for Membrane Biophysics at the Faculty of Biology and Environmental Protection at the University of Lodz in Poland. He has published widely in the field.

Affiliations and Expertise

Professor and Head, Molecular and Biophysics Department, and the Department for Membrane Biophysics, Faculty of Biology and Environmental Protection, University of Lodz, Poland

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