Lymphocyte Differentiation, Recognition, and Regulation

PrefaceI Introduction The Two Major Classes of Immunocompetent LymphocytesII Surface Antigens and Markers on T Lymphocytes A. Antigens Found Exclusively on T Cells B. Antigens on T Lymphocytes and on Other Nonlymphoid Cells, but Not Present on B LymphocytesIII Surface Antigens and Markers on B Lymphocytes A. Antigens Found Exclusively on Cells of the B Lymphocyte Lineage B. Antigens on B Lymphocytes and on Other Nonlymphoid Cells, but Not Present on T LymphocytesIV Surface Antigens Present on L Lymphocytes and also on B Lymphocytes A. The Major Histocompatibility Antigens B. The I-Region-Associated (Ia) Antigens C. The Fc Receptor (FcR) D. The Thymus-B Cell Common Antigen (Th-B) E. The LY-8 AntigenV Ontogeny of the Two Major Classes of Lymphocytes A. General Considerations B. Ontogeny of T Lymphocytes C. Ontogeny of B LymphocytesVI Surface Immunoglobulin on Lymphocytes A. Introduction B. Detection of Surface Immunoglobulin C. Quantitation of Surface Ig D. Tissue Distribution of Surface Ig+ Lymphocytes E. Ontogeny of Ig+ Lymphocytes F. Immunoglobulin Class Expression of Surface Ig on Lymphocytes G. Movement and Redistribution of Surface Immunoglobulin Molecules on B Lymphocytes H. Surface Immunoglobulin on T Lymphocytes I. Properties of Surface Immunoglobulin Isolated from B LymphocytesVII Immunological Specificity of Immunocompetent Lymphocytes A. Functional Evidence for Specificity in T and B Lymphocytes B. Comparative Specificities of the T and B Cell Repertoires C. Determinant Specificity of T and B Cell Receptors D. Antigen Receptors on B Lymphocytes E. Antigen Receptors on T LymphocytesVIII Functional Properties of T Lymphocytes A. Regulatory T Lymphocytes B. Effector T Lymphocytes C. Differential Sensitivities of T Cell Subpopulations to Chemical and Physical ManipulationsIX Functional Properties of B Lymphocytes A. Antibody-Forming Cell Precursors (AFCP) B. Functional Subpopulations of B Lymphocytes Distinguished by Relative Dependence on T Cells C. Other Criteria for Functional Subpopulations of B Lymphocytes D. Genetic Defects in T Lymphocyte FunctionX Regulatory Cellular Interactions in Immune Responses A. Basic Models of T-B Cell Interactions B. Nature of the Regulatory Influence of Activated T Cells on Antibody Production C. Suppressive Effects of T Lymphocytes on Antibody Production D. T Cell Regulation of IgE Antibody Synthesis E. Basic Models of T-T Cell Interactions F. Suppressive Effects of T Cells on Cell-Mediated Immune ResponsesXI The Allogeneic Effect on Immune Responses A. Essential Features of the Allogeneic Effect on Antibody Responses B. Mediation of the Allogeneic Effect via Development of the Graft-versus-Host Reaction C. The Allogeneic Effect In Vitro D. Relevance of the Allogeneic Effect to the Mechanism of Regulatory Physiological Interactions between T and B Lymphocytes in Immune Responses E. Pathophysiological Significance of the Allogeneic Effect F. ConclusionsXII Genetic Control of Immune Responses and Cellular Interactions A. Histocompatibility-Linked Ir Genes B. Histocompatibility-Linked Immune Suppression (Is) Genes C. The Role of Products of the Major Histocompatibility Complex in Cellular Interactions Which Regulate Immune Responses D. Relationship of Histocompatibility Gene Products to Each Other in Nature and Function E. General ConclusionsXIII Mechanisms of Regulatory Cellular Interactions A. General Considerations B. Properties of Biologically Active Products of Activated T Cells and Macrophages Mediating Helper or Suppressor Activities C. Hypothetical Models for Cellular InteractionsXIV Immunological Tolerance A. Historical Perspective B. Target Cells for Tolerance Induction C. Mechanisms of Tolerance Induction in Either T or B Lymphocytes D. Interrelationships among the Alternative Pathways to Unresponsiveness E. Relationships of the Alternative Pathways to Induction and Maintenance of Self-Tolerance F. Concluding RemarksXV Concluding RemarksGlossaryBibliographyIndex