Description

Each volume of Advances in Pharmacology provides a rich collection of reviews on timely topics. Emphasis is placed on the molecular basis of drug action, both applied and experimental.

Readership

Pharmacologists, cancer researchers, biochemists, microbiologists, cell biologists.

Table of Contents

J.C. Wang, DNA Topoisomerases as Targets of Therapeutics: An Overview. Y.-C. Tse-Dinh, Biochemistry of Bacterial Type I DNA Topoisomerases. R. Menzel and M. Gellert, The Biochemistry and Biology of DNA Gyrase.J.J. Champoux, Mechanism of Catalysis by Eukaryotic DNA Topoisomerase I. A.H. Andersen, J.Q. Svejstrup, and O. Westergaard, The DNA Binding, Cleavage, and Religation Reactions of Eukaryotic Topoisomerases I and II. J.L. Nitiss, Roles of DNA Topoisomerases in Chromosomal Replication and Segregation. M. Drolet, H.-Y. Wu., and L.F. Liu, Roles of DNA Topoisomerases in Transcription. H. Ikeda, DNA Topoisomerase-Mediated Illegitimate Recombination. J. Hwang and C.-L. Hwong,Cellular Regulation of Mammalian DNA Topoisomerases. T.-s. Hsieh, M.P. Lee, and S.D. Brown, Structure of Eurkaryotic Type I DNA Topoisomerase. W.M. Huang, Type II DNA Topoisomerase Genes. H.C. Neu, Major Advances in Antibacterial Quinolone Therapy. K. Drlica and B. Kreiswirth, 4-Quinolones and the Physiology of DNA Gyrase. L.L. Shen, Molecular Mechanisms of DNA Gyrase Inhibition by Quinolone Antibacterials. References. Subject Index.

Details

No. of pages:
320
Language:
English
Copyright:
© 1994
Published:
Imprint:
Academic Press
Electronic ISBN:
9780080581200
Print ISBN:
9780120329298
Print ISBN:
9780123994110

About the serial-volume-editor

Leroy Liu

Leroy F. Liu serves as the Chair and Professor in the Department of Pharmacology at the Robert Wood Johnson Medical School in Piscataway, New Jersey. Dr. Liu earned his B.S. in Chemistry at the National Taiwan University in 1971. He attended the University of California, Berkeley, and received his doctorate in Biophysical Chemistry in 1977. Liu has also held various teaching positions, including Visiting Professor at Academic Sinica in Taiwan and both Assistant and Associate Professor at the Johns Hopkins University School of Medicine.A Searle Scholar (1981-1984), Liu was awarded the American Chemical Society Faculty Research Award (1985-1990) and the George H. Hitchings Award for Innovative Drug Design in 1989. Dr. Liu's research interests include Topoisomerases in DNA structure and function, DNA damage and repair, and cancer biology and pharmacology. Along with this contribution to Advances in Pharmacology, Liu has written more than 100 scientific articles.

Reviews

@from:Praise for the Serial @qu:"The book provides superb reading material which chemists and pharmacologists interested in the area of chemotherapy will surely enjoy reading." @source:--JOURNAL OF PHARMACEUTICAL SCIENCES