Chemical Mediators of the Acute Inflammatory Reaction - 1st Edition - ISBN: 9780080170404, 9781483150512

Chemical Mediators of the Acute Inflammatory Reaction

1st Edition

International Series of Monographs in Pure and Applied Biology: Modern Trends in Physiological Sciences

Authors: M. Rocha E Silva J. Garcia Leme
Editors: P. Alexander Z. M. Bacq
eBook ISBN: 9781483150512
Imprint: Pergamon
Published Date: 1st January 1972
Page Count: 276
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Description

International Series of Monographs in Pure and Applied Biology, Modern Trends in Physiological Sciences, Volume 37: Chemical Mediators of the Acute Inflammatory Reaction traces the history of investigation into the acute inflammatory reaction from the early observations in invertebrates to the experiments of therapeutic significance for humans.

This book focuses on mediators that are accepted as being commonly involved in the inflammatory reaction, such as histamine, kinins, serotonin, prostaglandins, and permeability factors. The topics discussed include the phagocytic system and antibody production; factors which influence phagocytosis; measurement of the acute inflammatory reaction; and combined actions of mediators. The reaction to injury and manifestation of inflammation and biochemical aspects of anti-inflammatory drug reaction are also covered.

This volume is beneficial to anatomists, biochemists, physiologists, immunologists, pathologists, pharmacologists, and clinicians interested in acute inflammatory reaction.

Table of Contents


Preface

Acknowledgment

Chapter 1. Natural History of the Inflammatory Reaction

Earliest Theories on the Mechanism of Inflammation

Development of the Evidence

The Phagocytic System and Antibody Production

The Reticulo-Endothelial System (RES)

Factors which Influence Phagocytosis

Role of the Endothelial Cells

Role of Mast Cells

Conclusion

References

CHAPTER 2. Measurement of the Acute Inflammatory Reaction

Experimental Design

Peculiarities of the Methods Employed

Special Techniques

References

Chapter 3. Mediators of the Inflammatory Reaction

Mediators and "Immediators" of the Inflammatory Reaction

Histamine

Bradykinin and Related Kinins

High Molecular Permeability Factors

Combined Actions of Mediators

References

Chapter 4. Anti-Inflammatory Actions of Drugs

The Possible Mediators of Inflammation and Anti-Inflammatory Actions of Drugs

Effect of Anti-Inflammatory Drugs on Biogenesis and Releasing Systems of the Presumed Mediators

Reaction to Injury and Manifestation of Inflammation

Biochemical Aspects of Anti-Inflammatory Drug Reaction

Involvement of Nervous Structures in Inflammatory Reactions

Hormonal Influences on the Anti-Inflammatory Effects of Drugs

Conclusions

References

Author Index

Subject Index

Other Titles in the Division

Details

No. of pages:
276
Language:
English
Copyright:
© Pergamon 1972
Published:
Imprint:
Pergamon
eBook ISBN:
9781483150512

About the Author

M. Rocha E Silva

J. Garcia Leme

About the Editor

P. Alexander

Z. M. Bacq