Biomaterials for Cancer Therapeutics

Biomaterials for Cancer Therapeutics

Diagnosis, Prevention and Therapy

1st Edition - October 21, 2013
There is a Newer Edition Available
  • Editor: Kinam Park
  • eBook ISBN: 9780857096760
  • Hardcover ISBN: 9780857096647

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Description

Cancer can affect people of all ages, and approximately one in three people are estimated to be diagnosed with cancer during their lifetime. Extensive research is being undertaken by many different institutions to explore potential new therapeutics, and biomaterials technology is now being developed to target, treat and prevent cancer. This unique book discusses the role and potential of biomaterials in treating this prevalent disease.The first part of the book discusses the fundamentals of biomaterials for cancer therapeutics. Chapters in part two discuss synthetic vaccines, proteins and polymers for cancer therapeutics. Part three focusses on theranosis and drug delivery systems, whilst the final set of chapters look at biomaterial therapies and cancer cell interaction.This extensive book provides a complete overview of the latest research into the potential of biomaterials for the diagnosis, therapy and prevention of cancer. Biomaterials for cancer therapeutics is an essential text for academics, scientists and researchers within the biomedical industry, and will also be of interest to clinicians with a research interest in cancer therapies and biomaterials.

Key Features

  • A complete overview of the latest research into the potential of biomaterials for the diagnosis, therapy and prevention of cancer
  • Discusses the fundamentals of biomaterials for cancer therapeutics
  • Discusses synthetic vaccines, proteins and polymers for cancer therapeutics

Readership

Engineers/scientists working in the field of biomaterials with an emphasis on technologies for cancer; Researchers in pharmaceutical sciences, nanotechnologies, and related field

Table of Contents

  • Contributor contact details

    Woodhead Publishing Series in Biomaterials

    Preface

    Chapter 1: Introduction to biomaterials for cancer therapeutics

    Abstract:

    1.1 Introduction

    1.2 Biomaterials used in cancer therapeutics

    1.3 Materials used in anticancer formulations

    1.4 Conclusion and future trends

    Chapter 2: Cancer cell biology

    Abstract:

    2.1 Introduction

    2.2 Public perception and misunderstanding of cancer cell activity

    2.3 The ‘War on Cancer’

    2.4 The genetic basis of cancer

    2.5 Cancer interface with the environment

    2.6 Cancer cells as moving targets

    2.7 Conclusion and future trends

    Chapter 3: Targeted drug delivery for cancer therapy

    Abstract:

    3.1 Introduction

    3.2 Current paradigm

    3.3 Challenges to current paradigm

    3.4 Conclusion and future trends

    Chapter 4: Chemical synthesis of carbohydrate-based vaccines against cancers

    Abstract:

    4.1 Introduction

    4.2 Semi-synthetic vaccines

    4.3 Fully synthetic vaccines

    4.4 Conclusion and future trends

    Chapter 5: Generating functional mutant proteins to create highly bioactive anticancer biopharmaceuticals

    Abstract:

    5.1 Introduction

    5.2 Artificial proteins for cancer therapy

    5.3 How to create functional mutant proteins as beneficial therapeutics

    5.4 Mutant TNFα for cancer therapy

    5.5 Conclusion and future trends

    5.6 Sources of further information and advice

    Chapter 6: Polymer therapeutics for treating cancer

    Abstract:

    6.1 Introduction

    6.2 Polyamines and polyamine analogs

    6.3 Polymeric P-glycoprotein (Pgp) inhibitors

    6.4 Conclusion and future trends

    6.5 Acknowledgment

    Chapter 7: Nanotechnology for cancer screening and diagnosis

    Abstract:

    7.1 Introduction

    7.2 Nanotechnology for cancer diagnosis

    7.3 Nanotechnology-based biosensing platforms

    7.4 Nanotechnology for biosensing – early detection of cancer

    7.5 Nanotechnology for cancer imaging

    7.6 Concerns with using nanomaterials

    7.7 Conclusion and future trends

    Chapter 8: Synergistically integrated nanomaterials for multimodal cancer cell imaging

    Abstract:

    8.1 Introduction

    8.2 Nanomaterial-based multifunctional imaging probes

    8.3 Nanoparticles with exogenous imaging ligands

    8.4 Nanoparticles with endogenous contrast

    8.5 Cocktail injection

    8.6 Conclusion

    Chapter 9: Hybrid nanocrystal as a versatile platform for cancer theranostics

    Abstract:

    9.1 Introduction

    9.2 Imaging modality

    9.3 Developing theranostic systems

    9.4 Hybrid nanocrystal as theranostic platform

    9.5 Conclusion

    9.6 Acknowledgment

    Chapter 10: Embolisation devices from biomedical polymers for intra-arterial occlusion drug delivery in the treatment of cancer

    Abstract:

    10.1 Introduction

    10.2 Biomedical polymers and embolisation agents

    10.3 Particulate embolisation agents

    10.4 Drug-eluting embolisation beads

    10.5 Polymer structure, form and property relationships

    10.6 Experience with drug-eluting embolisation beads

    10.7 Conclusions and future trends

    10.8 Acknowledgement

    Chapter 11: Small interfering RNAs (siRNAs) as cancer therapeutics

    Abstract:

    11.1 Introduction

    11.2 Prerequisites for siRNAs cancer therapeutics

    11.3 Delivery systems for anticancer siRNAs

    11.4 Current challenges for clinical trials

    11.5 Conclusion

    11.6 Acknowledgement

    Chapter 12: Reverse engineering of the low temperature-sensitive liposome (LTSL) for treating cancer

    Abstract:

    12.1 Introduction

    12.2 What is reverse engineering?

    12.3 Investigating the thermal-sensitive liposome’s performance-in-service

    12.4 Defining the function of the liposome

    12.5 Component design: mechanism of action

    12.6 Selecting the most appropriate material when designing the Dox-LTSL

    12.7 Analysis of materials performance in the design

    12.8 Specification sheet

    12.9 Production

    12.10 Prototypes

    12.11 Further development

    12.12 Conclusion and future trends

    12.13 Acknowledgements

    Chapter 13: Gold nanoparticles (GNPs) as multifunctional materials for cancer treatment

    Abstract:

    13.1 Introduction

    13.2 Physical properties of gold nanoparticles

    13.3 Surface chemistry of GNPs

    13.4 GNPs as vehicles for drug delivery

    13.5 GNPs in biomedical imaging and theranostics

    13.6 GNPs as radiosensitizing agents

    13.7 Challenges in the development of GNPs as therapeutic agents

    13.8 Conclusion and future trends

    13.9 Acknowledgments

    Chapter 14: Multifunctional nanosystems for cancer therapy

    Abstract

    14.1 Introduction

    14.2 Design of multifunctional nanosystems

    14.3 Illustrative examples of multifunctional nanosystems for tumor-targeted therapies

    14.4 Polymeric nanosystems

    14.5 Lipid nanosystems

    14.6 Hybrid nanosystems

    14.7 Regulatory and clinical perspectives

    14.8 Conclusions

    Chapter 15: Biomaterial strategies to modulate cancer

    Abstract:

    15.1 Introduction

    15.2 Understanding cancer with biomaterials

    15.3 Molecular markers for cancer

    15.4 Biomaterials for cancer therapy

    15.5 Conclusion

    Chapter 16: 3D cancer tumor models for evaluating chemotherapeutic efficacy

    Abstract:

    16.1 Introduction

    16.2 Efforts to fight cancer

    16.3 Preclinical drug evaluation in cellular and animal models

    16.4 In vivo environment

    16.5 2D vs 3D culture systems

    16.6 3D tumor models

    16.7 Methods to culture multicellular tumor spheroids

    16.8 Conclusion

    Chapter 17: Nanotopography of biomaterials for controlling cancer cell function

    Abstract:

    17.1 Introduction

    17.2 The influence of surface topography and roughness of PLGA on cancer cells: creation of nanoscale PLGA surfaces

    17.3 The influence of nanoscale PLGA topographies on surface wettability and surface free energy

    17.4 The influence of PLGA nanotopographies on protein adsorption

    17.5 The impact of PLGA surface nanopatterns on cancer cell functions

    17.6 The impact of nanopatterns and LBL monolayers on cell functions

    17.7 Conclusions

    Index

Product details

  • No. of pages: 530
  • Language: English
  • Copyright: © Woodhead Publishing 2013
  • Published: October 21, 2013
  • Imprint: Woodhead Publishing
  • eBook ISBN: 9780857096760
  • Hardcover ISBN: 9780857096647

About the Editor

Kinam Park

Kinam Park is Showalter Distinguished Professor of Biomedical Engineering & Professor of Pharmaceutics at Purdue University, USA. His research focuses in the areas of nano/micro particles, polymer micelles, drug-eluting stents, extracellular matrix, fast dissolving tablets, and smart hydrogels.

Affiliations and Expertise

Professor of Biomedical Engineering and Professor of Pharmaceutics, Purdue University, USA