Polymers and Nanomaterials for Gene Therapy

Polymers and Nanomaterials for Gene Therapy

1st Edition - January 9, 2016
This is the Latest Edition
  • Editor: Ravin Narain
  • Hardcover ISBN: 9780081005200
  • eBook ISBN: 9780081005217

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Description

Polymers and Nanomaterials for Gene Therapy provides the latest information on gene therapy, a topic that has attracted significant attention over the past two decades for the treatment of inherited and acquired genetic diseases. Major research efforts are currently focused on designing suitable carrier vectors that compact and protect oligonucleotides for gene therapy. The book explores the most recent developments in the field of polymer science and nanotechnology, and how these advancements have helped in the design of advanced materials. Non-viral vector systems, including cationic lipids, polymers, dendrimers, peptides and nanoparticles, are potential routes for compacting DNA for systemic delivery. However, unlike viral analogues that have no difficulty in overcoming cellular barriers and immune defense mechanisms, non-viral gene carriers consistently exhibit significant reduced transfection efficiency due to numerous extra- and intracellular obstacles. Therefore, biocompatibility and potential for large-scale production make these compounds increasingly attractive for gene therapy. This book contains chapters on the engineering of polymers and nanomaterials for gene therapy, and how they can form complexes with DNA and avoid both in vitro and in vivo barriers. Other chapters describe in vitro, ex vivo, in vivo gene therapy studies, and the current issues affecting non-viral gene therapy.

Key Features

  • Explores current challenges in the research of genetic diseases
  • Discusses polymers for gene therapy and their function in designing advanced materials
  • Provides examples of organic and inorganic nanomaterials for gene therapy
  • Includes labeling, targeting, and assays
  • Looks at characterization, physico-(bio)chemical properties, and applications

Readership

Academics and graduate students researching gene therapy, and clinical scientists investigating cancer and other genetic diseases.  

Table of Contents

    • Current challenges of gene therapy
    • Engineering of polymers and nanomaterials for gene therapy
    • Detailed description of in vitro, ex vivo and in vivo gene therapy studies using polymers and nanomaterials

Product details

  • No. of pages: 302
  • Language: English
  • Copyright: © Woodhead Publishing 2016
  • Published: January 9, 2016
  • Imprint: Woodhead Publishing
  • Hardcover ISBN: 9780081005200
  • eBook ISBN: 9780081005217

About the Editor

Ravin Narain

Ravin Narain, PhD, P.Eng, FRSC is a Professor in the Department of Chemical and Materials Engineering, University of Alberta, Canada. Prof. Narain has made significant contributions to research on the design, fabrication, and characterization of novel polymers and nanomaterials for a wide range of applications. His research has also covered biomaterials, nanomedicine and regenerative medicine, with an emphasis on developing advanced materials for biomedical uses. He has published over 170 articles in peer-reviewed and high impact journals and has edited several books He is currently the section editor for the second edition of Comprehensive Glycoscience (Elsevier). He is also on the Advisory Board for Polymer Chemistry (RSC). He was the recipient for a Distinguished Visiting Scientist Award from CSIRO (Manufacturing), Melbourne, Australia (2017-2018).

Affiliations and Expertise

Professor, Department of Chemical and Materials Engineering, University of Alberta, Edmonton, AB, Canada