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8-Membered Heterocycle Synthesis
1st Edition - February 21, 2023
Author: Navjeet Kaur
Paperback ISBN:
9 7 8 - 0 - 3 2 3 - 9 5 6 5 2 - 9
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 9 5 6 5 3 - 6
8-Membered Heterocycle Synthesis focuses on both the new and established methods for the synthesis of various 8-membered heterocycles. 8-membered heterocyclic compounds act as… Read more
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8-Membered Heterocycle Synthesis focuses on both the new and established methods for the synthesis of various 8-membered heterocycles. 8-membered heterocyclic compounds act as target molecules for a wide range of synthetic studies and are present in a broad range of natural products, showing a wide variety of pharmaceutical and biological properties. Covering an important and rapidly growing branch of heterocyclic chemistry, this book brings together every protocol for the synthesis of 8-membered heterocycles in one place, allowing the reader to see all the possibilities for making a particular compound using one particular reagent.
Providing up-to-date and comprehensive information about the synthesis of medium-ring heterocycles and the latest information on this fast-moving field, with easy access to the synthetic protocols for different 8-membered heterocycles, case studies, and application, this book will be essential reading for students, pharmacologists, biochemists, organic and medicinal chemists, researchers, and academic professionals.
- Covers the different methodologies for the synthesis of eight-membered heterocycles
- Includes summary schemes for each type of heterocycle, giving an overview of all the reactants that can be used, and the experimental conditions
- Includes discussion of the applications of eight-membered heterocycles
Students and Researchers in Chemistry, Synthetic Chemists, Organic Chemists, Academics and professionals in the field of catalytic and organic chemistry
1. Synthesis of azocines
1.1 Introduction
1.2 Synthesis of azocines from diazo compounds
1.3 Synthesis of azocines from nitro compounds
1.4 Synthesis of azocines from amines
1.5 Synthesis of azocines from oxy-amine compounds
1.6 Synthesis of azocines from carbonyl-amine compounds
1.7 Photochemical synthesis of azocines
References
2. Synthesis of azocines by diene metathesis
2.1 Introduction
2.2 Synthesis of azocines from 1,3-dienes
2.3 Synthesis of azocines from 1,4-dienes
2.4 Copper-catalyzed synthesis of azocines from 1,9-dienes
2.5 Molybdenum-catalyzed synthesis of azocines from 1,9-dienes
2.6 Ruthenium-catalyzed synthesis of azocines from 1,9-dienes
2.7 Ruthenium-catalyzed synthesis of benzazocines from 1,9-dienes
2.8 Ruthenium-catalyzed synthesis of fused azocines from 1,9-dienes
2.9 Ruthenium-catalyzed synthesis of fused azocines from dienes
References
3. Synthesis of azocines by ring-expansion
3.1 Introduction
3.2 Ring-expansion of three-membered heterocycles for the synthesis of azocines
3.3 Ring-expansion of four-membered rings for the synthesis of azocines
3.4 Ring-expansion of four-membered heterocycles for the synthesis of azocines
3.5 Ring-expansion of five-membered rings for the synthesis of azocines
3.6 Ring-expansion of five-membered heterocycles for the synthesis of azocines
3.7 Ring-expansion of six-membered rings for the synthesis of azocines
3.8 Ring-expansion of six-membered heterocycles for the synthesis of azocines
3.9 Ring-expansion of seven-membered rings for the synthesis of azocines
3.10 Ring-expansion of seven-membered heterocycles for the synthesis of azocines
References
4. Synthesis of azocines and diazocines from amine containing alkenes and alkynes
4.1 Introduction
4.2 Synthesis of azocines from amine containing alkenes
4.3 Synthesis of azocines from amine containing alkynes
4.4 Synthesis of diazocines from amine containing alkenes and alkynes
References
5. Synthesis of diazocines
5.1 Introduction
5.2 Synthesis of diazocines from azides
5.3 Synthesis of diazocines from amines
5.4 Synthesis of diazocines by dimerization
5.5 Synthesis of diazocines from nitro compounds
5.6 Photochemical synthesis of diazocines
References
6. Synthesis of diazocines and oxocines by cyclization of dienes
6.1 Introduction
6.2 Synthesis of diazocines
6.3 Synthesis of oxocines
6.4 Synthesis of benzoxocines
6.5 Synthesis of fused oxocines
6.6 Synthesis of dioxocines
References
7. Synthesis of diazocines and oxocines by ring-contraction and -expansion
7.1 Introduction
7.2 Synthesis of diazocines
7.3 Synthesis of benzodiazocines
7.4 Synthesis of fused diazocines
7.5 Synthesis of fused benzodiazocines
7.6 Synthesis of tetrazocines
7.7 Synthesis of oxocines
7.8 Synthesis of benzoxocines
7.9 Synthesis of fused oxocines
7.10 Synthesis of dioxocines
References
8. Synthesis of azocines and oxocines by ring-closure of halo, amine and oxo compounds
8.1 Introduction
8.2 Synthesis of azocines from haloamines
8.3 Synthesis of benzazocines from haloamines
8.4 Synthesis of fused azocines from haloamines
8.5 Synthesis of fused benzazocines from haloamines
8.6 Synthesis of diazocines from haloamines
8.7 Synthesis of tetraazocines from amines
8.8 Synthesis of oxocines from oxo-halo compounds
8.9 Synthesis of benzoxocines from oxo-halo compounds
8.10 Synthesis of dioxocines from oxo-halo compounds
References
9. Synthesis of oxocines
9.1 Introduction
9.2 Synthesis of oxocines from hydroxy compounds
9.3 Synthesis of dioxocines from hydroxy compounds
9.4 Synthesis of trioxocines from hydroxy compounds
9.5 Synthesis of oxocines from ene-oxo compounds
9.6 Synthesis of dioxocines from ene-oxo compounds
9.7 Synthesis of oxocines from oxo-carbonyl compounds
9.8 Synthesis of oxocines from diazo compounds
9.9 Photochemical synthesis of dioxocines
References
10. Synthesis of oxazocines
10.1 Introduction
10.2 Synthesis of oxazocines
10.2.1 Synthesis of 1,3-oxazocines
10.2.2 Synthesis of 1,4-oxazocines
10.2.3 Synthesis of 2,5-oxazocines
10.2.4 Synthesis of 1,5-oxazocines
10.2.5 Synthesis of 1,6-oxazocines
10.3 Synthesis of oxadiazocines
10.4 Synthesis of dioxazocines
10.5 Synthesis of oxatriazocines
References
11. Synthesis of thiocines and thiazocines
11.1 Introduction
11.2 Synthesis of thiocines
11.3 Synthesis of dithiocines
11.4 Synthesis of tetra- and pentathiocines
11.5 Synthesis of 1,2-thiazocines
11.6 Synthesis of 1,3-thiazocines
11.7 Synthesis of 1,4-thiazocines
11.8 Synthesis of 1,4-benzothiazocines
11.9 Synthesis of 1,5-thiazocines
11.10 Synthesis of thiadiazocines
11.11 Synthesis of oxathiocines
11.12 Synthesis of oxathiazocines
References
1.1 Introduction
1.2 Synthesis of azocines from diazo compounds
1.3 Synthesis of azocines from nitro compounds
1.4 Synthesis of azocines from amines
1.5 Synthesis of azocines from oxy-amine compounds
1.6 Synthesis of azocines from carbonyl-amine compounds
1.7 Photochemical synthesis of azocines
References
2. Synthesis of azocines by diene metathesis
2.1 Introduction
2.2 Synthesis of azocines from 1,3-dienes
2.3 Synthesis of azocines from 1,4-dienes
2.4 Copper-catalyzed synthesis of azocines from 1,9-dienes
2.5 Molybdenum-catalyzed synthesis of azocines from 1,9-dienes
2.6 Ruthenium-catalyzed synthesis of azocines from 1,9-dienes
2.7 Ruthenium-catalyzed synthesis of benzazocines from 1,9-dienes
2.8 Ruthenium-catalyzed synthesis of fused azocines from 1,9-dienes
2.9 Ruthenium-catalyzed synthesis of fused azocines from dienes
References
3. Synthesis of azocines by ring-expansion
3.1 Introduction
3.2 Ring-expansion of three-membered heterocycles for the synthesis of azocines
3.3 Ring-expansion of four-membered rings for the synthesis of azocines
3.4 Ring-expansion of four-membered heterocycles for the synthesis of azocines
3.5 Ring-expansion of five-membered rings for the synthesis of azocines
3.6 Ring-expansion of five-membered heterocycles for the synthesis of azocines
3.7 Ring-expansion of six-membered rings for the synthesis of azocines
3.8 Ring-expansion of six-membered heterocycles for the synthesis of azocines
3.9 Ring-expansion of seven-membered rings for the synthesis of azocines
3.10 Ring-expansion of seven-membered heterocycles for the synthesis of azocines
References
4. Synthesis of azocines and diazocines from amine containing alkenes and alkynes
4.1 Introduction
4.2 Synthesis of azocines from amine containing alkenes
4.3 Synthesis of azocines from amine containing alkynes
4.4 Synthesis of diazocines from amine containing alkenes and alkynes
References
5. Synthesis of diazocines
5.1 Introduction
5.2 Synthesis of diazocines from azides
5.3 Synthesis of diazocines from amines
5.4 Synthesis of diazocines by dimerization
5.5 Synthesis of diazocines from nitro compounds
5.6 Photochemical synthesis of diazocines
References
6. Synthesis of diazocines and oxocines by cyclization of dienes
6.1 Introduction
6.2 Synthesis of diazocines
6.3 Synthesis of oxocines
6.4 Synthesis of benzoxocines
6.5 Synthesis of fused oxocines
6.6 Synthesis of dioxocines
References
7. Synthesis of diazocines and oxocines by ring-contraction and -expansion
7.1 Introduction
7.2 Synthesis of diazocines
7.3 Synthesis of benzodiazocines
7.4 Synthesis of fused diazocines
7.5 Synthesis of fused benzodiazocines
7.6 Synthesis of tetrazocines
7.7 Synthesis of oxocines
7.8 Synthesis of benzoxocines
7.9 Synthesis of fused oxocines
7.10 Synthesis of dioxocines
References
8. Synthesis of azocines and oxocines by ring-closure of halo, amine and oxo compounds
8.1 Introduction
8.2 Synthesis of azocines from haloamines
8.3 Synthesis of benzazocines from haloamines
8.4 Synthesis of fused azocines from haloamines
8.5 Synthesis of fused benzazocines from haloamines
8.6 Synthesis of diazocines from haloamines
8.7 Synthesis of tetraazocines from amines
8.8 Synthesis of oxocines from oxo-halo compounds
8.9 Synthesis of benzoxocines from oxo-halo compounds
8.10 Synthesis of dioxocines from oxo-halo compounds
References
9. Synthesis of oxocines
9.1 Introduction
9.2 Synthesis of oxocines from hydroxy compounds
9.3 Synthesis of dioxocines from hydroxy compounds
9.4 Synthesis of trioxocines from hydroxy compounds
9.5 Synthesis of oxocines from ene-oxo compounds
9.6 Synthesis of dioxocines from ene-oxo compounds
9.7 Synthesis of oxocines from oxo-carbonyl compounds
9.8 Synthesis of oxocines from diazo compounds
9.9 Photochemical synthesis of dioxocines
References
10. Synthesis of oxazocines
10.1 Introduction
10.2 Synthesis of oxazocines
10.2.1 Synthesis of 1,3-oxazocines
10.2.2 Synthesis of 1,4-oxazocines
10.2.3 Synthesis of 2,5-oxazocines
10.2.4 Synthesis of 1,5-oxazocines
10.2.5 Synthesis of 1,6-oxazocines
10.3 Synthesis of oxadiazocines
10.4 Synthesis of dioxazocines
10.5 Synthesis of oxatriazocines
References
11. Synthesis of thiocines and thiazocines
11.1 Introduction
11.2 Synthesis of thiocines
11.3 Synthesis of dithiocines
11.4 Synthesis of tetra- and pentathiocines
11.5 Synthesis of 1,2-thiazocines
11.6 Synthesis of 1,3-thiazocines
11.7 Synthesis of 1,4-thiazocines
11.8 Synthesis of 1,4-benzothiazocines
11.9 Synthesis of 1,5-thiazocines
11.10 Synthesis of thiadiazocines
11.11 Synthesis of oxathiocines
11.12 Synthesis of oxathiazocines
References
- No. of pages: 564
- Language: English
- Published: February 21, 2023
- Imprint: Elsevier
- Paperback ISBN: 9780323956529
- eBook ISBN: 9780323956536
NK
Navjeet Kaur
Dr. Navjeet Kaur received her BSc from Panjab University Chandigarh (Panjab, India) in 2008. In 2010, she completed her MSc in Chemistry from Banasthali Vidyapith. She was awarded with PhD in 2014 by the same university. With 11 years of teaching experience, she has published over 160 scientific research papers, review articles, book chapters, and monographs in the field of organic synthesis in national and international reputed journals. She has published five authored books: with Elsevier. She secured her place amongst top 2% scientists of the world in 2017 (single year ranking), 2018 (full career wise ranking), 2019 [full career wise ranking with 424 world rank (04 in India) and single year ranking with 03 world rank (01 in India)] and 2020 (full career wise ranking with 372 world rank and single year ranking with 126 world rank). In 2021, Dr. Kaur was chosen as a candidate for membership by Royal Society of Research, London, England, UK with full waiver of application fees. She is serving as an Editor-in-Chief of the “Advanced Chemicobiology Research” journal.
Affiliations and expertise
Associate Professor, Department of Chemistry and Division of Research and Development, Lovely Professional University, Phagwara, Punjab, India