Editor’s Choice in Autoimmunity

Explore a handpicked selection of influential research from three esteemed journals dedicated to advancing knowledge in autoimmune diseases:

Our editorial teams have selected these standout articles for their significance, innovation, and impact on the field. Whether you’re a researcher, clinician, or student, this collection offers essential insights to keep you at the forefront of autoimmune disease research and care.

Editor’s Choice: Selected research highlights from autoimmunity journals

Dear Readers, We are pleased to present a selection of impactful papers chosen by the editorial teams from three distinguished journals: Journal of Translational Autoimmunity, Journal of Autoimmunity, and Autoimmunity Reviews. This collection highlights significant advancements in understanding autoimmune diseases and related therapeutic strategies.

Journal of Translational Autoimmunity

• Single-cell transcriptomic analysis uncovers heterogeneity in the labial gland microenvironment of primary Sjögren's syndrome This research employs single-cell transcriptomics to reveal the complex cellular landscape within the labial glands of patients with primary Sjögren's syndrome. The findings indicate significant heterogeneity, which may inform targeted therapeutic approaches.

• Cellular therapies in rheumatic and musculoskeletal diseases This article reviews the current landscape of cellular therapies in treating rheumatic and musculoskeletal diseases, discussing recent advances, challenges, and future directions for these innovative treatments.

• Urinary soluble CD163 is useful as “liquid biopsy” marker in lupus nephritis at both diagnosis and follow-up to predict impending flares The study investigates urinary soluble CD163 as a potential liquid biopsy marker for lupus nephritis. The results demonstrate its utility in diagnosing and monitoring disease progression, offering insights into predicting flares in affected patients.

Journal of Autoimmunity

• Advances in chimeric antigen receptor T cell therapy for autoimmune and autoinflammatory diseases and their complications This paper highlights recent advances in chimeric antigen receptor (CAR) T cell therapy, exploring its applications in treating autoimmune and autoinflammatory diseases. The authors discuss both the potential benefits and complexities of this therapy.

• Poorer survival for patients with inflammatory arthritis treated with immune checkpoint inhibitors for melanoma This research reports on the survival outcomes of patients with inflammatory arthritis who were treated with immune checkpoint inhibitors for melanoma. The findings suggest that these patients may experience poorer survival rates, raising important clinical considerations.

• Exploring glucagon-like peptide-1 receptor agonists as potential disease-modifying agents in autoimmune diseases The article evaluates the potential of glucagon-like peptide-1 receptor agonists as disease-modifying agents in various autoimmune conditions. The authors discuss the mechanisms of action and clinical implications of these therapies.

Autoimmunity Reviews

• Global, regional, and national burden of inflammatory bowel disease and its associated anemia, 1990 to 2019 and predictions to 2050: An analysis of the global burden of disease study 2019 This comprehensive analysis assesses the global and regional burden of inflammatory bowel disease (IBD) and associated anemia from 1990 to 2019, with projections to 2050. The findings highlight the growing public health challenge posed by IBD.

• Is fibromyalgia an autoimmune disorder? This thought-provoking article explores the controversial question of whether fibromyalgia should be classified as an autoimmune disorder. The authors review existing literature and propose a framework for understanding the condition in relation to autoimmune mechanisms.

• Subclinical giant cell arteritis in polymyalgia rheumatica: Concurrent conditions or a common spectrum of inflammatory diseases? The study examines the relationship between subclinical giant cell arteritis and polymyalgia rheumatica, questioning whether these conditions represent concurrent diseases or part of a broader spectrum of inflammatory disorders.

Editor’s Choice: Essential reads in autoimmunity

Stay ahead with the latest research shaping the future of autoimmune disease care. We’ve handpicked key studies from Autoimmunity Reviews, Journal of Autoimmunity, and Journal of Translational Autoimmunity—so you can quickly access insights that matter for your work.

Autoimmunity Reviews:

• Global burden and cross-country inequalities in autoimmune diseases from 1990 to 2019 This comprehensive study examines the worldwide prevalence of autoimmune diseases over three decades, uncovering significant disparities between countries. It sheds light on the socioeconomic and healthcare factors driving these inequalities, emphasizing the need for targeted global health strategies.

• Global, regional, and national burden of inflammatory bowel disease and its associated anemia, 1990 to 2019 and predictions to 2050: An analysis of the global burden of disease study 2019 An in-depth analysis tracking the impact of inflammatory bowel disease (IBD) and its common complication, anemia, across different regions. The authors project future trends up to 2050, providing crucial data for healthcare planning and intervention development.

Journal of Autoimmunity:

• Gut microbiome, metabolome, host immunity associated with inflammatory bowel disease and intervention of fecal microbiota transplantation This article explores the complex interactions between gut bacteria, metabolic profiles, and immune responses in IBD patients. It also evaluates the promising therapeutic role of fecal microbiota transplantation in restoring gut health and modulating disease activity.

• Gut microbiota in pre-clinical rheumatoid arthritis: From pathogenesis to preventing progression Focusing on early-stage rheumatoid arthritis, this study investigates how alterations in gut microbiota contribute to disease onset. The findings highlight potential microbiome-targeted interventions that could delay or prevent progression to full-blown arthritis.

Journal of Translational Autoimmunity:

• Ppar agonists for the treatment of primary biliary cholangitis: Old and new tales Reviewing both established and emerging peroxisome proliferator-activated receptor (PPAR) agonists, this article discusses their therapeutic potential in managing primary biliary cholangitis, offering insights into drug mechanisms and future treatment directions.

• Could a simple biomarker as neutrophil-to-lymphocyte ratio reflect complex processes orchestrated by neutrophils? This provocative piece examines the neutrophil-to-lymphocyte ratio as an accessible biomarker, questioning whether it can effectively mirror the intricate immune functions of neutrophils in autoimmune conditions, with implications for diagnosis and monitoring.

Stay informed with these expertly selected articles and deepen your understanding of the evolving landscape in autoimmunity research.