Elsevier adds 43 million Enamine make-on-demand compounds to Reaxys to accelerate chemistry R&D

Elsevier, a global leader in information and analytics, and Enamineopens in new tab/window, a global leader in supplying small molecules and early drug discovery services, have announced a partnership to integrate Enamine’s database of over 43 million make-on-demand (MADE) analog compounds into Reaxys. The integration will provide chemists with unparalleled access to a diverse array of chemical compounds for accelerated drug discovery and materials science research.

Reaxys is a leading chemical database that combines over a billion chemistry data points from scientific journals and patents with AI to support innovation in drug discovery, chemical R&D and academia. This new integration combines Enamine's expertise in compound synthesis with the comprehensive capabilities of the Reaxys platform, enabling researchers to access a vast repository of chemical information and facilitating the identification of novel drug targets, biomarkers, and screening compounds.

Enamine has a >70% success rate for generating novel make-on-demand compounds and can typically synthesize compounds in two to six weeks. This helps chemists to significantly accelerate the Make stage of the Design-Make-Test-Analyze (DMTA) cycle, reducing development times and costs by up to 90%.

Mirit Eldor, Managing Director, Life Sciences Solutions at Elsevier, said: “Chemists across all sectors are under more pressure than ever to accelerate development of novel and innovative products. Enamine’s high success rate has made it one of the most important suppliers of substances for researchers. By integrating Enamine’s database into Reaxys, chemists will have access to millions of quick-to-make novel analog compounds, allowing them to critically accelerate the DMTA cycle. This latest partnership further enhances the value that Reaxys offers to customers as the most up-to-date chemical database in the world.”

Enamine’s compounds are derived from Enamine MADE building blocks and Enamine REAL (REadily AccessibLe) screening compounds, and are prepared from in-stock available reagents in 1-5 well-validated synthetic steps. Each compound is cataloged with detailed information on pricing and lead time, providing researchers with valuable insights to streamline their research processes.

Prof. Dr. Andrey Tolmachov, Founder and CEO of Enamine, said: “The decision on whether to make or buy compounds is one that chemists face every day. It is typically quicker and less expensive for chemists to buy compounds rather than make them in-house – so they need to be confident that they are buying from a supplier with quick turnaround times and a high success rate. We are excited to be integrating our database into Reaxys to give even more researchers access to compounds that can accelerate the discovery and development of transformative products.”

The collaboration is supported by Chemspace, an expert in the generation and exploration of ultra-large chemical datasets. Chemspace will provide its infrastructure for streamlining order processing for Enamine.

Enamine’s compound database is available now to all Reaxys customers. For more information visit the Reaxys product page.

About Enamine

Enamine is a scientifically driven integrated discovery Contract Research Organization with unique partnering opportunities in exploring new chemical space. The company combines access to the in-house produced screening compounds (4.4M in stock) and building blocks (300K in stock) with a comprehensive platform of integrated discovery services to advance and accelerate the efforts in Drug Discovery.

Enamine MADE (MAke-on-DEmand) building blocks are a catalog of over 1 billion chemical building blocks that can be synthesized within several weeks using pre-validated experience and starting materials from Enamine in-stock reagents in 1-5 steps with over 70% success rate. For more information visit: https://enamine.net/building-blocks/made-building-blocksopens in new tab/window

Enamine REAL contains trillions of synthetically feasible molecules that can be synthesized at Enamine extremely fast (3-4 weeks), with high feasibility (over 80%), and inexpensive. The REAL Compounds are created by parallel chemistry through the compilation of 143,000 in-stock building blocks via 167 well-validated parallel synthesis protocols, underlying Enamine’s approach to design make-on-demand compounds to maximize synthesis success rate.

Both products, Enamine MADE Building Blocks and Enamine REAL Compounds, enable shortening the DMTA cycle by delivering novel hit analogs fast and thus speeding up the discovery projects.

엘스비어 소개

엘스비어는 첨단 정보와 의사결정 지원 분야의 글로벌 선도 기업으로 100년 넘게 과학과 헬스케어의 발전을 지원하며 인류 진보에 기여해 왔습니다. 우리는 170개국 이상에서 학술 및 기업 연구 커뮤니티, 의사, 간호사, 미래의 의료 전문가와 교육자들을 지원합니다. 근거에 기반한 신뢰할 수 있는 과학·의학 콘텐츠와 최첨단 AI 기술을 결합해 중요한 통찰과 혁신적인 솔루션을 제공해, 의미있는 성과를 이루도록 돕고 있습니다. 또한 다양성과 지속 가능성을 제품과 기업 문화 전반에 내재화하며, 우리가 속한 커뮤니티와 협력합니다. 엘스비어 재단opens in new tab/window은 전 세계에서 연구와 보건 파트너십을 지원합니다.

엘스비어는 전문가 및 기업 고객에게 정보 기반의 분석과 의사결정 도구를 제공하는 글로벌 기업 RELXopens in new tab/window의 일원입니다. 자세한 내용은 www.elsevier.com에서 확인할 수 있으며, 소셜미디어 @elsevierconnect를 통해 최신 소식을 받아보실 수 있습니다.