Racism takes its toll on brain and body

Structural racism has not only psychosocial but also biological consequences. Discrimination has been shown to contribute to mental and physical disorders including obesity, depression, and addiction, but the biological pathways from a social experience to its impacts on the body remain unknown. A new study 新しいタブ／ウィンドウで開く examines the role of the brain-gut microbiome (BGM) system in discrimination-related health issues.

The study appears in Biological Psychiatry 新しいタブ／ウィンドウで開く, published by Elsevier.

Past research around discrimination and illness pointed to the hypothalamic-pituitary-adrenal axis, which regulates stress, but the authors wanted to broaden their scope. Recent studies have found that the BGM is also highly responsive to stressful experiences. Dysregulation of the BGM is associated with inflammation and long-term health issues resulting from immune cell, neuronal, and hormone signaling that link our experiences to our health.

The new study, led by Tien S. Dong, MD, PhD, and Gilbert C. Gee, PhD, at UCLA, tests the hypothesis that discrimination influences the central and enteric nervous systems, thus altering the bidirectional signaling between the brain and gut microbiome as mediated by inflammation.

Recognizing that past research exploring discrimination and illness predominantly compared Black and White individuals, the authors investigated multiple racial and ethnic groups. The study included 154 adults in the Los Angeles community who self-reported their race or ethnicity as Asian American, Black, Hispanic, or White. Participants completed questionnaires to assess experiences of discrimination.

Participants of all ethnic and racial backgrounds reported experiences of discrimination, although they reported a variety of reasons for discrimination, ranging from race to sex to age. “These different reasons were associated with different changes in the BGM system across the different racial and ethnic groups,” explains Dr. Dong.

The researchers collected functional magnetic resonance imaging data to assess the link between discrimination and brain connectivity. They also collected blood samples to measure inflammatory markers and fecal samples to assess the microbial population and its metabolites. Together, these metrics were used to assess discrimination-related BGM alterations and psychological variables, while controlling for sex, age, body mass index, and diet.

“Our research suggests that for Black and Hispanic individuals, discrimination leads to changes that include increased systemic inflammation,” explained Dr. Dong. “For Asian individuals, the patterns suggest [that] possible responses to discrimination include somatization, or the production of multiple medical symptoms with no discernible known cause. Among White individuals, discrimination was related to anxiety but not inflammation. But just as importantly, for all races, discrimination also had an increase in the emotional arousal and limbic regions of the brain, which are associated with the stress response of fight or flight. We also saw elevations in pro-inflammatory microbes such as Prevotella copri.”

John Krystal, MD, editor of Biological Psychiatry, said, “This new study sheds light on the broad impact of exposure to racism on emotions, brain activity, inflammatory markers in the blood, and the composition of the gut microbiome. We would not be surprised to learn that exposure to racism affects how we feel and how we cope with this exposure and other life stresses. However, this study goes further to highlight brain patterns of response to racism and other factors that affect physical health, including the types of bacteria growing in the gut and the levels of inflammation in the body. These are factors that influence many disease processes in the body."

The work suggests that discrimination produces group-specific effects on certain biological pathways, providing a first step toward understanding how social inequities become whole-body experiences.

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Notes for editors

The article is “How Discrimination Gets Under the Skin: Biological Determinants of Discrimination Associated with Dysregulation of the Brain-Gut Microbiome System and Psychological Symptoms," by Tien S. Dong, Gilbert C. Gee, Hiram Beltran-Sanchez, May Wang, Vadim Osadchiy, Lisa A. Kilpatrick, Zixi Chen, Vishvak Subramanyam, Yurui Zhang, Yinming Guo, Jennifer S. Labus, Bruce Naliboff, Steve Cole, Xiaobei Zhang, Emeran A. Mayer, and Arpana Gupta (https://doi.org/10.1016/j.biopsych.2022.10.011 新しいタブ／ウィンドウで開く). It appears as an Article in Press in Biological Psychiatry 新しいタブ／ウィンドウで開く, published by Elsevier.

The paper is openly available at https://www.biologicalpsychiatryjournal.com/article/S0006-3223(22)01703-6/fulltext 新しいタブ／ウィンドウで開く.

Copies of this paper are also available to credentialed journalists upon request; please contact Rhiannon Bugno at +1 254 522 9700 or [email protected] 新しいタブ／ウィンドウで開く. Journalists wishing to interview the authors may contact Tien S. Dong, MD, PhD, at [email protected] 新しいタブ／ウィンドウで開く, Gilbert C. Gee, PhD, at [email protected] 新しいタブ／ウィンドウで開く, or Arpana Gupta, PhD, at [email protected] 新しいタブ／ウィンドウで開く.

The authors’ affiliations and disclosures of financial and conflicts of interests are available in the article.

John H. Krystal, MD, is Chairman of the Department of Psychiatry at the Yale University School of Medicine, Chief of Psychiatry at Yale-New Haven Hospital, and a research psychiatrist at the VA Connecticut Healthcare System. His disclosures of financial and conflicts of interests are available here 新しいタブ／ウィンドウで開く.

About Biological Psychiatry

Biological Psychiatry 新しいタブ／ウィンドウで開く is the official journal of the Society of Biological Psychiatry 新しいタブ／ウィンドウで開く, whose purpose is to promote excellence in scientific research and education in fields that investigate the nature, causes, mechanisms and treatments of disorders of thought, emotion, or behavior. In accord with this mission, this peer-reviewed, rapid-publication, international journal publishes both basic and clinical contributions from all disciplines and research areas relevant to the pathophysiology and treatment of major psychiatric disorders.

The journal publishes novel results of original research which represent an important new lead or significant impact on the field, particularly those addressing genetic and environmental risk factors, neural circuitry and neurochemistry, and important new therapeutic approaches. Reviews and commentaries that focus on topics of current research and interest are also encouraged.

Biological Psychiatry is one of the most selective and highly cited journals in the field of psychiatric neuroscience. It is ranked 12^th out of 155 Psychiatry titles and 14^th out of 274 Neurosciences titles in the Journal Citations Reports^TM published by Clarivate Analytics. The 2021 Impact Factor score for Biological Psychiatry is 12.810. www.sobp.org/journal 新しいタブ／ウィンドウで開く

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