EJIM High-impact articles

Explore the future of internal medicine

Discover a selection of high-impact articles from the European Journal of Internal Medicine, featuring innovative research published in 2024, 2025, and 2026. These studies address critical health challenges and offer fresh insights that can transform patient care. Join us in exploring these groundbreaking findings and contribute to the ongoing conversation in internal medicine.

Together, let’s shape a healthier future.

Review articles

Assessment and management of cardiovascular–kidney–liver metabolic-syndrome in the primary care setting: A multidisciplinary consensus statement by Reinhold Kreutz et al. (2026)opens in new tab/window
Frailty measurement in research and clinical practice: A review by Elsa Dent et al. (2026)opens in new tab/window
Earlier Prediction of Cardiovascular Risk with Epicardial Fat Assessment by Giuseppe Calcaterra et al. (2026)opens in new tab/window
Triglyceride glucose (TyG) index: A promising biomarker for diagnosis and treatment of different diseases by Yuting Sun et al. (2025)opens in new tab/window
Bridging the gap: Time to integrate sex and gender differences into research and clinical practice for improved health outcomes by Roberta Gualtierotti (2025)opens in new tab/window
Practical management of severe acute pancreatitis by Karim Hamesch et al. (2025)opens in new tab/window
Translating evidence into practice: Managing electrolyte imbalances and iron deficiency in heart failure by Ryosuke Sato et al. (2025)opens in new tab/window
Tularemia for clinicians: An up-to-date review on epidemiology, diagnosis, prevention and treatment by Roberta Maria Antonello et al. (2025)opens in new tab/window
Artificial intelligence and the electrocardiogram: A modern renaissance by Stefano Palermi et al. (2025) opens in new tab/window
Comprehensive management of pneumonia in older patients by Alain Putot et al. (2025)opens in new tab/window
Impact of micro- and nanoplastics on gastrointestinal diseases: Recent advances by Haonan Zhao et al. (2025)opens in new tab/window
Point of care ultrasound: focus on evidence for a critical appraisal by E. Ceriani et al. (2025)opens in new tab/window
Ultra-processed foods and cardio-kidney-metabolic syndrome: A review of recent evidence by Mehmet Kanbay et al. (2025)opens in new tab/window
Chronic obstructive pulmonary disease's eosinophilic phenotype: Clinical characteristics, biomarkers and biotherapy by Mauro Maniscalco et al. (2025)opens in new tab/window
Drug-induced hyponatremia in clinical care by Buster Mannheimer et al. (2025)opens in new tab/window
How to promote healthy aging across the life cycle by Camilla Cocchi et al. (2025)opens in new tab/window
Senolytic therapies for cardiovascular aging: tackling fibrosis and metabolic dysfunction by Sandra Atlante et al. (2025)opens in new tab/window
New strategies for the treatment of hyperkalemia by Stefano Masi et al. (2025)opens in new tab/window
Beyond creatinine: New methods to measure renal function? by M. Salman Sheikh et al. (2025)opens in new tab/window
The role of the senescence-associated secretory phenotype in cardiovascular disease among the elderly by Henry Sutanto et al. (2025)opens in new tab/window
Cancer genetic profile and risk of thrombosis by Francisco J. Pelegrín-Mateo et al. (2025)opens in new tab/window
Crystal clear – part I: The role of uric acid in cardiorenal disease by Claudio Borghi et al. (2025)opens in new tab/window

Original articles

Effectiveness of tezepelumab in severe asthma: A multicenter real-world study by Remo Poto et al. (2026)opens in new tab/window
Evaluations of metabolic and innate immunity profiles in subjects with familial hypercholesterolemia with or without subclinical atherosclerosis by Giosiana Bosco et al. (2025)opens in new tab/window
Hyperhomocysteinemia is linked to MASLD by Carlo De Matteis et al. (2025)opens in new tab/window
A large language model-based clinical decision support system for syncope recognition in the emergency department: A framework for clinical workflow integration by Alessandro Giaj Levra et al. (2025)opens in new tab/window
Risk trajectory of cardiovascular events after an exacerbation of chronic obstructive pulmonary disease: A systematic review and meta-analysis by Edoardo Pirera et al. (2025)opens in new tab/window
Hypertensive heart disease in older patients: considerations for clinical practice by Miguel Camafort et al. (2025)opens in new tab/window
Safety and efficacy of early initiation of sodium-glucose co-transporter inhibitors 2 in patients hospitalized for acute heart failure: A meta-analysis of randomized controlled trials by Renzo Laborante et al. (2025)opens in new tab/window
Chronic kidney disease classification according to different formulas and impact on adverse outcomes in patients with atrial fibrillation: A report from a prospective observational European registry by Giuseppe Boriani et al. (2025)opens in new tab/window
Modifiable lifestyle factors in the primordial prevention of hypertension in three US cohorts by Rikuta Hamaya et al. (2025)opens in new tab/window
A person-centred clinical approach to the multimorbid patient with COPD by Bartolome R. Celli et al. (2025)opens in new tab/window
Exploring phenotypes to improve long-term mortality risk stratification in obstructive sleep apnea through a machine learning approach: an observational cohort study by Pasquale Tondo et al. (2025)opens in new tab/window
Metabolic dysfunction-associated steatotic liver disease (MASLD). Assessing metabolic dysfunction, cardiovascular risk factors, and lifestyle habits by Hala Abdallah et al. (2025)opens in new tab/window
Serum interleukin-18 levels are specifically elevated in auto-inflammatory diseases involving the pyrin inflammasome: A study on 516 patients by Inès Elhani et al. (2025)opens in new tab/window
Sex-related differences in the management and outcome of intubated adults with community-acquired pneumonia in Europe: A multicentre study by Nicolas Garin et al. (2025)opens in new tab/window
Intermediate Care Units in Internal Medicine by Ciro Canetta et al. (2025)opens in new tab/window
The role of an intermediate care unit in reducing intensive care unit admissions and improving patient outcomes in internal medicine: A quasi-experimental study by Gianni Turcato et al. (2025)opens in new tab/window
Clinical characteristics and outcomes of Takotsubo syndrome in patients with chronic obstructive pulmonary disease by Luca Arcari et al. (2025)opens in new tab/window
sTREM2 evaluation in women with metabolic dysfunction-associated steatotic liver disease: Advancing diagnostic approaches for early MASH by Razieh Mahmoudian et al. (2025)opens in new tab/window
Promoting women's careers in life science and medicine: A position paper from the “International Women in Intensive Medicine” network by Olfa Hamzaoui et al. (2025)opens in new tab/window
Prevalence and impact of multidrug resistance in a cohort of patients admitted to emergency department for urinary tract-infections: The UTILY study, a prospective multicentre study by Lorenzo Onorato et al. (2025)opens in new tab/window

Other

Comparative safety and efficacy analysis of GLP-1 receptor agonists and SGLT-2 inhibitors among frail individuals with type 2 diabetes in the era of continuous population ageingopens in new tab/window by Paschalis Karakasis et al. (2025)
The lowest well tolerated blood pressure: A personalized target for all?opens in new tab/window by Verdecchia (2024)
Metabolic dysfunction-associated steatotic liver disease: Evolution of the final terminologyopens in new tab/window by Portincasa (2024)
Towards precision medicine in COPD: Targeting type 2 cytokines and alarminsopens in new tab/window by Varricchi (2024)
Glucagon-like peptide-1 receptor agonists and sodium-glucose cotransporter-2 inhibitors combination therapy versus monotherapy and major adverse cardiovascular events: Do the benefits add up?opens in new tab/window by Karakasis (2024)