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 | COMBINATORIAL CHEMISTRY - A PRIMER
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To order this title, and for more information, click here
Edited By
A Ganesan, School of Chemistry, University of Southampton, U.K.
Description
Traditionally, organic synthesis is concerned with the preparation of a single target molecule in an efficient maner. This includes, for
example, the well established areas ot total synthesis in academia and process chemistry in industry. Recently, the development of high-throughput
methods for screening compounds has precipitated a change in the classical paradigm. For many applications, it is now useful (or even
necessary) to prepare a large set of compounds. This is the basis of combinatorial chemistry, or parallel organic synthesis as it is
often referred to.
The book begins with an introduction, followed by a detailed discussion of the organic reactions that are widely
used in parallel synthesis. Both solution and solid-phase methods are covered and throughout the intention is to guide the reader's understanding
of the principles. The next section of the book is concerned with the important issue of what types of compounds should be made, and
covers current thinking on library design.
The second half of the book describes a series of illustrative examples of combinatorial
chemistry and parallel synthesis. These are primarily taken from drug discovery applications, and include both synthesis of discrete
and pooled libraries. Each chapter of the book contains an extensive bibliography of both reviews and the primary literature.
Audience
This book is suitable for researchers in pharmaceutical, biotech and academia fields. It is also suitable for advanced undergraduate or graduate students.
Bibliographic & ordering Information
Hardbound, publication date: APR-2010
ISBN-13: 978-0-08-044792-6
ISBN-10: 0-08-044792-9
Imprint: ELSEVIER
Price: Order form
USD 176 GBP 110 EUR 160
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Last update: 30 Aug 2008
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