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| HANDBOOK OF MICRODIALYSIS, 16
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 Methods, Applications and Perspectives
To order this title, and for more information, click here
Ben Westerink, Research Institute of Pharmacy, University of Groningen, The Netherlands
Thomas Cremers, Research Institute of Pharmacy, University of Groningen, The Netherlands
Included in series
Handbook of Behavioral Neuroscience,
Description
Microdialysis is currently one of the most important in vivo sampling methods in physiology and pharmacology. It is used to determine
the chemical components of the fluid in the extracellular space of tissues. The technique is now well established in neuroscience research
and is used excessively in behavioral neuroscience to determine the concentrations and identities of molecules in brain tissues, and
their change due to behavior, hormonal and transmitter changes in the nervous system. The book provides a detailed comprehensive overview
of the technology and its applications, including application in pathology, drug development, and the application in the clinic. The
authors are all well known researchers in Neuroscience and experts in the use of Microdialysis.
Organized into two parts of seven sections,
the Handbook of Microdialysis critically examines recent developments in the field through a variety of chapters written by an
internationally acclaimed group of authors. It is the first comprehensive handbook covering the technology of Microdialysis and its
applications in Neuroscience.
Audience
Graduate, post-doc students and researchers in neurobiology, neurochemistry, and neuropharmacology.
Contents
PART ONE
Interpretation and significance.
What Did We Learn from Microdialysis?
Microdialysis: fact or artefact .
Insights into
Glutamate Physiology: Contribution of Studies Utilizing In Vivo Microdialysis.
The Validity of Intracerebral Microdialysis.
Microdialysis
in the Brain of Anaesthetized vs Freely Moving Animals.
Quantitative Aspects of Brain Microdialysis: Insights from Voltammetric Measurements
of Dopamine next to Microdialysis Probes.
Methods.
New methodological aspects of microdialysis.
Principles of Quantitative
Microdialysis.
Automation of Blood and Microdialysis Sampling: Combinatorial Pharmacology.
Dopamine-Acetylcholine Interactions in the
Brain Studied by In Vivo Microdialysis.
Microdialysis as a Platform for Multidisciplinary Strategies.
Ultraslow Microfiltration and
Microdialysis for in vivo Sampling: Principle, Techniques and Applications.
Analytical chemical aspects of microdialysis
Liquid
Chromatographic Methods Used for Microdialysis.
Microdialysis Coupled with Liquid Chromatography / Mass Spectrometry.
Sampling Improvement
of the Temporal Resolution of Brain Microdialysis: Sampling in Seconds.
In Vivo Peptidomics: Discovery and Monitoring of Neuropeptides
Using Microdialysis and Liquid Chromatography with Mass Spectrometry.
PART TWO
Microdialysis and the study of behaviour.
Microdialysis
to Study the Effects of Stress on Serotonin, Corticosterone and Behaviour.
Microdialysis of Dopamine and Norepinephrine During Conditioning
and Operant Behaviour.
Microdialysis in the Study of Behavior Reinforcement and Inhibition.
Changes in Acetylcholine Extracellular Levels
During Cognitive Processes.
CNS Pathology models.
Microdialysis in Genetically Altered Animals.
The Use of Microdialysis in
Neuropsychiatric Disease Models.
The Use of Microdialysis for the Study of Neurological Disorders.
Online Glucose and Lactate Monitoring
During Physiological and Pathological Conditions.
Microdialysis in Pain Research.
Role of microdialysis in drug development.
The Role of Microdialysis in Drug Discovery: Focus on Antipsychotic Agents.
Use of Microdialysis in Drug Discovery and Development:
Industry and Regulatory Perspectives.
The Use of Brain Microdialysis in Antidepressant Drug Research.
Microdialysis as a Method to
Study Blood-Brain Barrier Transport Mechanisms.
Assaying Protein Unbound Drugs Using Microdialysis Techniques.
Microdialysis for Characterization
of PK/PD Relationships.
Application of Microdialysis in Pharmacokinetic Studies
Clinical applications.
Microdialysis in Clinical
Drug Delivery Studies.
Transport of Glucose to a Probe in Adipose Tissue.
Microdialysis in the Human Brain: Clinical applications.
| Bibliographic details |
Hardbound, 712 pages, publication date: JAN-2007
ISBN-13: 978-0-444-52276-4
ISBN-10: 0-444-52276-X
Imprint: ACADEMIC PRESS
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| Price and Ordering |
Price:
GBP 86
EUR 125
USD 149.95
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095/945
Last update: 27 Sep 2008
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