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| HEMATOLOGY E-DITION
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 Text with Continually Updated Online Reference
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Fourth Edition
By
Ronald Hoffman, MD, Eileen Heidrick Professor of Oncology, Chief, Section of Hematology-Oncology, Department of Medicine, University of Illinois, College of Medicine, Chicago, IL
Edward Benz, MD, Jack D. Myers Professor and Chairman, Department of Medicine, University of Pittsburgh School of Medicine; Attending Physician, Department
of Internal Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA
Sanford Shattil, MD, Professor, Departments of Vascular Biology and Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA,
Adjunct Professor of Medicine, University of California at San Diego, San Diego, CA
Bruce Furie, MD, Professor of Medicine, Harvard Medical School; Chief, Division of Hemostasis and Thrombosis, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA
Harvey Cohen, MD, PhD, Professor and Chairman, Department of Pediatrics, Stanford University Medical Center Stanford, CA
Leslie Silberstein, MD, Director, Joint Program in Transfusion Medicine, Children?s Hospital Boston, Dana-Farber Cancer Institute, And Brigham and Women?s
Hospital; Professor of Pathology (Pediatrics), Harvard Medical School, Boston, MA
Philip McGlave, MD, Cecil J. Watson Professor of Medicine, Director, Division of Hematology, Oncology, and Transplantation, Department of Medicine, University of Minnesota, Minneapolis, MN
Description
The fourth edition of this leading text reflects the new direction and growth of the field of hematology as an academic and clinical discipline.
Both a state-of-the-art website and a critically acclaimed reference.
Audience
Hematologists
Contents
Part I. MOLECULAR AND CELLULAR BASIS OF HEMATOLOGY
Chapter 1: Anatomy and Physiology of the Gene
Chapter 2: Genomic Approaches
to the Study of Hematologic Science
Chapter 3: Protein Synthesis, Processing, and Degradation
Chapter 4: Protein Architecture:
Relationship of Form and Function
Chapter 5: Regulation of Cellular Response
Chapter 6: Cell Adhesion
Chapter 7: Control of
Cell Division
Chapter 8: Cell Death
Chapter 9: Pharmacogenomics and Hematological Diseases
Part II. IMMUNOLOGIC BASIS OF
HEMATOLOGY
Chapter 10: Overview and Compartmentalization of the Immune System
Chapter 11: B-Cell Development
Chapter 12:
T-Cell and NK-Cell Immunity
Chapter 13: Dendritic Cell Biology
Chapter 14: Regulation of Activation of B and I Lymphocytes
Chapter
15: Leukocyte Trafficking
Chapter 16: Tolerance and Autoimmunity
Part III. BIOLOGY OF STEM CELLS AND DISORDERS OF HEMATOPOIESIS
Chapter
17: Stem Cell Model of Hematopoiesis
Chapter 18: Bone Marrow Microenvironment
Chapter 19: The Humeral Regulation of Hematopoiesis
Chapter
20: Biology of Erythropoiesis, Erythroid Differentiation, and Maturation
Chapter 21: Granulopoiesis and Monocytopoiesis
Chapter
22: Thrombocytopoiesis
Chapter 23: Thrombocytopenia Due to Decreased Platelet Production
Chapter 24: Inherited Forms of Bone Marrow
Failure
Chapter 25: Aplastic Anemia
Chapter 26: Paroxysmal Nocturnal Hemoglobinuria
Chapter 27: Pure Red Cell Aplasia
Part
IV. RED BLOOD CELLS
Chapter 28: Pathobiology of the Human Erythrocyte and Its Hemoglobins
Chapter 29: Approach to Anemia in
the Adult and Child
Chapter 30: Anemia of Chronic Diseases
Chapter 31: Pathology of Iron Metabolism
Chapter 32: Disorders of
Iron Metabolism: Iron Deficiency and Overload
Chapter 33: Heme Biosynthesis and Its Disorders: Porphyrias and Sideroblastic Anemias
Chapter
34: Megablastic Anemias
Chapter 35: Thalassemia Syndromes
Chapter 36: Pathology of Sickle Cell Disease
Chapter 37: Sickle Cell
Disease
Chapter 38: Hemoglobin Variants Associated with Hemolytic Anemia, Altered Oxygen Affinity, and Methemoglobinemias
Chapter
39: Red Cell Enzymopathies
Chapter 40: Red Cell Membrane Disorders
Chapter 41: Autoimmune Hemolytic Anemias
Chapter 42: Extrinsic
Nonimmune Hemolytic Anemias
Part V. HOST DEFENSE AND ITS DISORDERS
Chapter 43: Complement Biology and Immunoglobulin
Chapter
44: Normal Phagocyte Structure and Function
Chapter 45: Eosinophilia, Eosinophil-Associated Diseases, Chronic Eosinophil Leukemia,
and the Hypereosinophilic Syndromes
Chapter 46: Disorders of Phagocyte Function and Number
Chapter 47: Disorders of Lymphocyte
Function
Chapter 48: Histiocytic Disorders
Chapter 49: Lysosomal Storage Diseases: Perspective and Principles
Chapter 50 Infectious
Mononucleosis and Other Epstein-Barr Virus-Associated Diseases
Chapter 51: The Spleen and Its Disorders
Chapter 52: Basophils,
Mast Cells, and Systemic Mastocytosis
Part VI. HEMATOLOGIC MALIGNANCIES
Chapter 53: Conventional Cytogenetics and Molecular
Cytogenetics in Hematological Malignancies
Chapter 54: The Molecular Basis of Neoplasia
Chapter 55: Pharmacology and Molecular
Mechanisms of Antineoplastic Agents for Hematologic Malignancies
Chapter 56: Radiation Therapy in the Treatment of Hematologic Malignancies
Chapter
57: Clinical Use of Hematopoietic Growth Factors
Chapter 58: Radioimmunotherapy for B-Cell and Non-Hodgkin Lymphoma
Chapter 59:
Pathobiology of Acute Myeloid Leukemia
Chapter 60: Clinical Manifestations of Acute Myeloid Leukemia
Chapter 61: Therapy for Acute
Myeloid Leukemia
Chapter 62: Acute Myeloid Leukemia in Children
Chapter 63: Pathobiology of Acute Lymphoblastic Leukemia
Chapter
64: Clinical Manifestations of Acute Lymphoblastic Leukemia
Chapter 65: Treatment of Childhood Acute Lymphoblastic Leukemia
Chapter
66: Acute Lymphoblastic Leukemia in Adults
Chapter 67: Myelodysplastic Syndrome: Biology and Treatment
Chapter 68: Polycythemia
Vera
Chapter 69: Chronic Myeloid Leukemia
Chapter 70: Myelofibrosis with Myeloid Metaplasia
Chapter 71: Essential Thrombocythemia
Chapter
72: Myelodysplastic Syndromes and Myeloproliferative Syndromes in Children
Chapter 73: Pathobiology of Non-Hodgkin Lymphomas
Chapter
74: Patho-Biology of Hodgkin?s Lymphoma
Chapter 75: Hodgkin?s Disease: Clinical Manifestations, Staging, and Therapy
Chapter 76:
The Pathologic Basis for the Classification of Non-Hodgkin Lymphomas
Chapter 77: Clinical Manifestations, Staging, and Treatment of
Non-Hodgkin Lymphoma
Chapter 78: Malignant Lymphomas in Childhood
Chapter 79: Chronic Lymphocytic Leukemia
Chapter 80: Hairy
Cell Leukemia
Chapter 81: Cutaneous T-Cell Lymphomas
Chapter 82: AIDS-Related Lymphomas
Chapter 83: Multiple Myeloma and Other
Plasma Cell Disorders
Chapter 84: Immunoglobulin Light Chain Amyloidosis (Primary Amyloidosis, AL)
Chapter 85: Atypical Immune
Lymphoproliferations
Chapter 86: Clinical Approaches to Infections in the Compromised Host
Chapter 87: Nutritional Support of Patients
with Hematologic Malignancies
Chapter 88: Psychosocial Aspects of Hematologic Disorders
Chapter 89: Pain Management and Antiemetic
Therapy in Hematologic Disorders
Chapter 90: Palliative Care
Chapter 91: Indwelling Access Devices
Chapter 92: Late Complications
of Hematologic Diseases and Their Therapies
Part VII. TRANSPLANTATION
Chapter 93: Hematopoietic Stem Cell Transplantation
for Acquired Nonmalignant Diseases and Myelodysplastic Syndrome
Chapter 94: Hematopoietic Cell Transplant for Immune Deficiences and
Genetic Diseases
Chapter 95: Results of Allogeneic Hematopoietic Cell Transplant for Hematologic Malignancies
Chapter 96: Autologous
Transplant for Hematologic malignancies and Solio Tumors
Chapter 97: Unrelated Donor Stem Cell Transplantation Therapy Anasetti
Chapter
98: Umbilical Cord Blood Transplantation
Chapter 99: Preparative Regimens for Hematopoietic Cell Transplantation
Chapter 100:
Graft-versus-Host Disease and Graft-versus-Leukemia
Chapter 101: Graft Engineering to Enhance Engraftment, Reduce Graft-versus-Host
Disease and Provide a Graft-versus-Tumor Effect
Chapter 102: Gene Transfer for Hematologic Disorders
Chapter 103: Experimental
Cell Therapy
Chapter 104: Complications After Hematopoietic Cell Transplantation
Part VIII. HEMOSTASIS AND THROMBOSIS
Chapter
105: Megakaryocyte and Platelet Structure
Chapter 106: The Molecular Basis for Platelet Function
Chapter 107: The Molecular Basis
for Platelet Activation
Chapter 108: The Blood Vessel Wall
Chapter 109: Molecular Basis of Blood Coagulation
Chapter 110: Molecular
and Cellular Basis of Fibrinolysis
Chapter 111: Regulatory Mechanisms in Hemostasis: Natural Anticoagulants
Chapter 112: Clinical
Evaluation of Hemorrhagic Disorders: Bleeding History and Differential Diagnosis of Pupura
Chapter 113: Laboratory Evaluation of Hemostatic
Disorders
Chapter 114: Structure, Biology, and Genetics of Factor VIII
Chapter 115: Biochemistry of Factor IX and Molecular Biology
of Hemophilia B
Chapter 116: Clinical Aspects and Therapy of Hemophilia
Chapter 117: Inhibitors in Hemophilia
Chapter 118: Other
Clotting Factor Deficiencies
Chapter 119: Disorders of Fibrinogen
Chapter 120: Structure, Biology, and Genetics of von Willebrand
Factor
Chapter 121: von Willebrand Disease: Clinical Aspects and Therapy
Chapter 122: Vitamin K: Metabolism and Disorders
Chapter
123: Inhibitors of Blood Coagulation
Chapter 124: Disseminated Intrvascular Coagulation
Chapter 125: Hemostatic Defects Associated
with Dysproteinemias
Chapter 126: Disorders of Coagulation in the Neonate
Chapter 127: Hypercoagulable States
Chapter 128: Venous
Thromboembolism
Chapter 129: Arterial Thromboembolism
Chapter 130: Anticoagulation and Thrombolytic Therapy
Chapter 131: Immune
Thrombocytopenic Purpura, Neonatal Alloimmune Thrombocytopenia, and Posttransfusion Purpura
Chapter 132: Thrombotic Thrombocytopenic
Purpura and the Hemolytic Uremic Syndrome
Chapter 133: Thrombocytopenia Due to Platelet Destruction and Hypersplenism
Chapter 134:
Hereditary Disorders of Platelet Function
Chapter 135: Acquired Disorders of Platelet Function
Part IX. TRANSFUSION MEDICINE
Chapter
136: Human Blood Group Anitgens and Antibodies - Part 1: Carbohydrate Determinants - Part 2: Protein Determinants
Chapter 137: Human
Platelet Antigens
Chapter 138: Human Leukocyte Antigen (HLA) and Human Neutrophil Antigen (HNA) Systems
Chapter 139: Principles
of Red Blood Cell Transfusion
Chapter 140: Principles of Platelet Transfusion Therapy
Chapter 141: Principles of Neutrophil (Granulocyte)
Transfusions
Chapter 142: Transfusion of Plasma Derivatives: Fresh-Frozen Plasma, Cryoprecipitate, Albumin, and Immunoglobulins
Chapter
143: Preparation of Plasma-Derived and Recombinant Human Plasma Proteins
Chapter 144: Transfusion Therapy for Coagulation factor Deficiencies
Chapter 145: Hemapheresis and Cellular Therapy
Chapter 146: Practical Aspects of Stem Cell Collection
Chapter 147: Transfusion
Reactions
Chapter 148: Transfusion-Transmitted Diseases
Chapter 149: Transfusion Medicine in Hematopoietic Stem Cell and Solid
Organ Transplantation
Chapter 150: Red Blood Cell Substitutes
Part X. CONSULTATIVE HEMATOLOGY
Chapter 151: Hematologic
Manifestations of Systemic Disease: Liver and Renal Disease
Chapter 152: Hematologic Manifestations of Systemic Disease: Infection,
Chronic Inflammation, and Cancer
Chapter 153: Hematologic Manifestations of AIDS
Chapter 154: Hematologic Problems in the Surgical
Patient: Bleeding and Thrombosis
Chapter 155: Hematologic Aspects of Pregnancy
Chapter 156: Hematologic Manifestations of Childhood
Illness
Part XI. SPECIAL TESTS AND PROCEDURES
Chapter 157: Bone Marrow Examination
Chapter 158: Automated Analysis of
Blood Cells
Chapter 159: Laboratory Detection of Hemoglobinopathies and Thalassemias
Chapter 160: Antenatal Diagnosis of Hematologic
Disorders
Chapter 161: Use of Molecular Techniques in the Analysis of Hematologic Diseases
Chapter 162: Molecular Imaging in Hematology
Appendix
- Normal Blood Values: Selected Reference Values for Neonatal, Pediatric, and Adult Populations
| Bibliographic details |
Hardbound, publication date: DEC-2004
ISBN-13: 978-0-443-06662-7
ISBN-10: 0-443-06662-0
Imprint: CHURCHILL LIVINGSTONE
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Last update: 27 Sep 2008
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