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 To order this title, and for more information, click here
Edited By
B. Castellano López, Department of Cell Biology, Physiology and Immunology, Autonomous University of Barcelona, Campus de Bellaterra, 08193 Barcelona, Spain
M. Nieto-Sampedro, Instituto Cajal (CSIC), Avenida del Doctor Arce 37, 28002 Madrid, Spain
Description
Although knowledge of the development and differentiation of glial cells has significantly increased in recent years, there are still
many questions unanswered. The first section of the book is devoted to this very active topic and includes contributions on Schwann
cells, oligodendrocytes, astroglia and microglia.
The second section of the book covers cellular interactions, the role they play on
myelination and remyelination, how these interactions take place and the molecules involved.
The third section of this volume focuses
on the interactions of neurons with glial cells and their role in brain function. Neuron-glia cross talk appears to be fundamental for
synaptic transmission and several chapters in this section address this topic.
The topic of how glial cells react to brain injury
and how they participate in neuroprotection and brain repair is covered in section four of this book. As our knowledge about the molecules
involved in the regenerative properties of glia increases, new avenues are open for the use of genetically modified glia with therapeutic
purposes.
The final section of the book is devoted to therapeutic approaches to tumours, viral and prion infections. Gene therapy
is a promising approach for the treatment of gliomas, one of the most devastating forms of cancer. A chapter on prion diseases and microglia
addresses a question of tremendous actuality, since prion diseases in cows is at this moment the major veterinary problem in Europe and
has created a considerable social alarm.
Audience
Neuroscientists.
Contents
List of contributors.
Preface.
Glial cell development: origin and phenotype acquisition.
1. Regulation of genes involved in
Schwann cell development and differentiation
(R. Mirsky, D.B. Parkinson, Z. Dong, C. Meier, E. Calle, A. Brennan, P. Topilko, B. Harris,
G. Zoidl, H.J.S. Stewart, K.R. Jessen).
2. Regulation of radial glia phenotype
(P. LePrince, G. Chanas-Sacre).
3. Astrocytic intermediate
filaments: lessons from GFAP and vimentin knock-out mice
(M. Pekny).
4. Glial cells: a target for steroid hormones
(R.C. Melcangi,
V. Magnaghi, M. Galbiati, L. Martini).
5. Thyroid hormone role on nervous system morphogenesis
(F.C.A. Carvalho, A. Gomes, F.R.S. Lima,
A.G. Trentin, V. Moura Neto).
6. Early origin and colonization of the developing CNS by microglial precursors
(M.A. Cuadros, J. Navascués).
7. Microglia: its development and role as a neuropathology sensor
(E.A. Ling, Y.K. Ng, C.H. Wu, C. Kaur).
8. Colonisation of the
human central nervous system by microglia: the roles of chemokines and vascular adhesion molecules
(D. Male, P. Rezaie).
Myelination,
demyelination and remyelination.
9. Astrocyte influences on oligodendrocyte progenitor migration
(O. Schnädelbach, J.W. Fawcett).
10. Tenascin-R as a regulator of CNS glial cell function
(P. Pesheva, S. Gloor, R. Probstmeier).
11. Process extension and myelin
sheet formation in maturing oligodendrocytes
(P.C. Buttery, C. ffrench-Constant).
12. Recent advances in human perinatal white matter
injury
(S.A. Back).
13. Models for demyelination
(A. Van Der Goes, C.D. Dijkstra).
14. The response of adult oligodendrocyte progenitors
to demyelination in EAE
(R. Reynolds, I. Cenci Di Bello, M. Dawson, J. Levine).
15. Neural precursors and demyelinating diseases
(L.
Decker, F. Lachapelle, A. Baron-Van Evercooren).
16. What roles do growth factors play in CNS remyelination?
(R.J.M. Franklin, G.L.
Hinks, R.H. Woodruff, M.T. O'Leary).
Glial-neuronal interactions.
17. Molecular mechanisms of interactions between radial glia
and neurons
(B. McGrath, C. McCann, S. Eisenhuth, E.S. Anton).
18. Connexins and gap junctional communication in astrocytes are targets
for neuroglial interaction
(N. Rouach, C. Giaume).
19. Glial signalling in response to neuronal activity in the leech central nervous
system
(J.W. Deitmer, C. Lohr, F.C. Britz, J. Schmidt).
20. Glial cells as active partners in synaptic functions
(A. Castonguay, S.
Lévesque, R. Robitaille).
21. Calcium signaling in retinal glial cells and its effect on neuronal activity
(E.A. Newman).
22.
Neuron-astrocyte cross-talk during synaptic transmission: physiological and neuropathological implications
(P. Bezzi, M. Domercq, S.
Vesce, A. Volterra).
23. Regulation of glutamate transporters in health and disease
(G. Gegelashvili, M.B. Robinson, D. Trotti, T. Rauen).
24. Ionotropic glutamate receptors in astrocytes
(G. Seifert, C. Steinhäuser).
25. Metabotropic glutamate receptors in freshly
isolated astrocytes from rat hippocampus
(H.K. Kimelberg, M. Zhou, Z. Cai, G.P. Schools).
26. The pleiotropin/midkine family of cytokines:
role in glial-neuronal signaling
(L. Haynes, M. Rumsby).
27. The nitric oxide/cyclic GMP system in astroglial cells
(M.A. Baltrons,
A. García).
28. Glial diffusion barriers during aging and pathological states
(E. Syková).
Glial response to injury
and molecular mechanisms of neuroprotection.
29. Glial cells responses to lysophospholipids bound to albumin in serum and plasma
(A. Nadal, E. Fuentes, P.A. McNaughton).
30. Glial activation in the immature rat brain: implication of inflammatory transcription factors
and cytokine expression
(L. Acarin, B. González, B. Castellano).
31. Role of nuclear factor Kappa B in neuropathological mechanisms
(D.F. Cechetto).
32. Ischemia: astrocytes show their sensitive side
(R. Fern).
33. Adaptative responses of spinal astrocytes to oxidative
stress
(P. Cassina, H. Peluffo, L. Barbeito).
34. Glial expression of heat shock proteins (HSPs) and oxygen regulated protein (ORPs)
(F.R. Sharp, M. Bernaudin, M. Bartels, K.R. Wagner).
35. Nitric oxide-mediated mitochondrial impairment in neural cells: a role for
glucose metabolism in neuroprotection (J.P. Bolaños, P. García-Nogales, V. Vega-Agapito, M. Delgado-Esteban, P. Cidad, Á. Almeida).
36. Keeping TNF-induced apoptosis under control in astrocytes: PEA-15 as a "double key" on caspase-dependent and
MAP-kinase dependent pathways
(D. Zvalova, E. Formstecher, M. Fauquet, B. Canton, H. Chneiweiss).
37. Astroglia play a key role in the
neuroprotective actions of estrogen
(I. Azcoitia, D. Garcia-Ovejero, J.A. Chowen, L.M. García-Segura).
Inflammation and cytokine
signalling
38. Cytokine-mediated inflammation and signaling in the intact central nervous system
(I.L. Campbell).
39. Inhibition
of nitric oxide production for down-regulation of CNS inflammation and demyelination
(T. Brenner, F. Pinto, O. Abramsky, R. Gallily).
40. Chemokine targets in acute brain injury and disease
(D.C. Anthony, D. Blond, R. Dempster, V.H. Perry)
41. Microglial chemokines
and chemokine receptors
(P.J. Gebicke-Haerter, O. Spleiss, L.-Q. Ren, H. Li, S. Dichmann, J. Norgauer, H.W.G.M. Boddeke).
42. The role
of chemokines and chemokine receptors in CNS inflammation
(C.J.A. De Groot, M.N. Woodroofe).
43. Signals regulating neurotrophin expression
in glial cells
(U. Otten, P. März, K. Heese, C. Hock, D. Kunz, S. Rose-John).
44. Microglial signalling cascades in neurodegenerative
disease
(J. M. Pocock, A.C. Liddle).
Repair and regeneration.
45. Transcription factors in nerve regeneration
(P. Küry,
F. Bosse, H.W. Müller).
46. The role of astrocytes in axonal regeneration in the mammalian CNS
(M. Giménez y Ribotta, V.
Menet, A. Privat).
47. Chondroitin sulphate proteoglycans: inhibitory components of the glial scar
(R.A. Asher, D.A. Morgenstern, L.D.F.
Moon, J.W. Fawcett).
48. Axon regeneration across the dorsal root entry zone
(M.S. Ramer, S.B. McMahon, J.V. Priestley).
49. Transplants
of olfactory bulk ensheathing cells promote functional repair of multiple dorsal rhizotomy
(J.S. Taylor, V.C. Muňetón-Gómez,
R. EguRa-Recuero, M. Nieto-Sampedro).
50. Regulatable and cell-type specific transgene expression in glial cells: prospects for gene
therapy for neurological disorders
(M. Castro, A. Hurtado-Lorenzo, P.Umana, J.R. Smith-Arica, A. Zermansky, E. Abordo-Adesida, R. Löwenstein).
Therapeutical approaches to tumours, viral and prion infections.
51. Immune escape of gliomas
(P.R. Walker, P.Y. Dietrich).
52. Clinical trials of adenoviral-mediated suicide gene therapy of malignant gliomas
(D. Nanda, M.J. Driesse, P.A.E. Sillevis-Smitt).
53. Gene therapy of glioblastomas: from suicide to homicide
(G. Finocchiaro).
54. Glial cells as targets of viral infection in the
human central nervous system
(B. Schweighardt, W.J. Atwood).
55. Pathogenesis of prion diseases - possible implications of microglial
cells
(F.L. Heppner, M. Prinz, A. Aguzzi).
Bibliographic & ordering Information
Paperback, 780 pages, publication date: SEP-2003
ISBN-13: 978-0-444-51486-8
ISBN-10: 0-444-51486-4
Imprint: ELSEVIER
Price: Order form
USD 250
GBP 125
EUR 185
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Last update: 29 Aug 2008
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