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 To order this title, and for more information, click here
Edited By
Helen Osborn, Department of Chemistry, University of Reading, Whiteknights, Reading
Included in series
Best Synthetic Methods,
Description
There is a vast and often bewildering array of synthetic methods and reagents available to organic chemists today. The Best Synthetic
Methods series allows the practising synthetic chemist to choose between all the alternatives and assess their real advantages and
limitations.
Each chapter in this book details a particular theme associated with carbohydrate synthesis. A brief review of the
subject area is provided, but the emphasis in all cases is on describing efficient practical methods to effect the transformations described.
In order for the roles of carbohydrates to be thoroughly analysed and assessed, glycobiologists require access to defined target
carbohydrates in useful quantities. Thus carbohydrates and glycoconjugates are now recognized as important targets for total synthesis
programmes and it is essential to develop efficient regio- and stereoselective methods for the synthesis of carbohydrates. Whilst carbohydrates
can sometimes be isolated from natural sources, synthetic strategies often offer the advantage of allowing access to larger quantities
of material as well as entry to analogues of the natural carbohydrates.
Audience
For general supplementary reading and as a reference book for use in organic chemistry research laboratories. It is also appropriate as
a supplementary text and reference book for university courses and for the practical classes on synthetic organic chemistry.
Contents
An introduction to carbohydrate synthesis (H.M.I. Osborn). Selective hydroxyl protection and deprotection (J. Robertson, P.M. Stafford).
Synthesis and activation of carbohydrate donors : acetates, halides, phenylselenides and glycals ( B.G. Davis et al.). Synthesis
and activation of carbohydrate donors : thioglycosides and sulfoxides (K.P.R. Kartha, R.A. Field). Synthesis and activation of carbohydrate
donors : acetimidates, n-pentenyl and vinyl glycosides (A.J. Fairbanks, C.M.P. Seward). Modern glycosidation methods: tuning
of reactivity (J. Pietruszka). Modern glycosidation methods: orthogonal glycosidation (J. Pietruszka). The stereoselective synthesis
of ?-mannosides (S.C. Ennis, H.M.I. Osborn). Synthesis of sialic acid containing carbohydrates (H. Ando et al.). The synthesis
of glycosyl amino acids (P.G. Evans et al.). The synthesis of C-linked glycosides (P. Meo, H.M.I. Osborn). The uses
of glycoprocessing enzymes in synthesis (B.G. Davis, S.J. Hancock).
Bibliographic & ordering Information
Hardbound, 452 pages, publication date: APR-2003
ISBN-13: 978-0-12-312085-4
ISBN-10: 0-12-312085-3
Imprint: ACADEMIC PRESS
Price: Order form
USD 200
GBP 105
EUR 165
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Last update: 29 Aug 2008
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