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| CONTROL AND DISEASES OF SODIUM DEPENDENT TRANSPORT PROTEINS AND ION CHANNELS
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 Proceedings of the First International Conference, Shizuoka, Japan, 24-28 August 1999
Edited by
Y. Suketa, University of Shizuoka, School of Pharmaceutical Sciences, Department of Environmental Biochemistry & Toxicology, Shizuoka, Japan
E. Carafoli, University of Padova, School of Medicine, Department of Biological Chemistry, Padova, Italy
M. Lazdunski, Institute de Pharmacologie Moleculaire et Cellulaire, Valbonne, France
K. Mikoshiba, University of Tokyo, Institute of Medical Sciences, Department of Molecular Neurobiology, Tokyo, Japan
Y. Okada, National Institute for Physiological Sciences, Department of Cellular & Molecular Physiology, Okazaki, Japan
E.M. Wright, University of California School of Medicine, Department of Physiology, Los Angeles, CA, USA
Included in series
International Congress, 1208
Description
Control and diseases of sodium dependent transport proteins and ion channels is believed to be one of the scientific research fields which
holds great interest for biomedical investigators. The topics of gene expression, modulation and traffic of ion channels, transporters
and receptors are progressing tremendously in cellular and molecular biology. The expression and regulation of these areas has profound
implications for research in fields such as neuronal systems, intra- and intercellular signaling and close talking, cell prolification
and differentiation, and ion mobilization. Evidence from this research has fundamental effect on drug design, dialysation and gene therapy
as clinical tools.
The contributions in this volume are grouped according to subject. Much focus is placed on molecular biology,
regulatory mechanism, gene expression, physiology, pharmacology, toxicology and drug design related to Na/H exchanger, Na/Ca exchanger,
Na channel, CI channel, Na pump, GABA transporter, organic anion transporter and others in the plasma membrane of various organs.
Audience
Perfect for all scientists working in phamacology, physiology, biochemistry, endocrinology and toxicology.
Contents
1. Structure and Function of Na/K-ATPase.
Reviews.
Structure and function of Na+ or K+ (Tl+)
binding sites in Na, K-ATPase
(P.L. Jorgensen et al.).
How ouabain works: Key role of the PLasmERosome
(M.P. Blaustein, A.
Arnon, J.M. Hamlyn).
Mechanisms of aldosterone's action on epithelial Na+ transport
(D.C. Eaton et al.).
New aspects
of Na/K-ATPase: Acid labile ATP and/or ADP/Pi binding to the tetraprotomer, (αβ)4
(K. Taniguchi et al.).
Conformational
and functional changes in rat renal Na/K-ATPase caused by aging
(Y. Suketa et al.).
Gating role of the N-terminus of α-subunit
of the Na+/K+-ATPase converted into a channel by palytoxin.
(L.A. Vasilets et al.).
Transcriptional regulation of Na,K-ATPase alpha 1 subunit gene
(K. Kawakami).
Regular articles.
Hypertensinogenic action
of ouabain as a sodium transport inhibitor
(A. Goto et al.).
Na+ translocation by the cardiac Na+/K+
pump is accelerated by the cAMP-PKA pathway
(J. Kockskamper, S. Erlenkamp, H.G. Glitsch).
The mechanism of induction of THP-1 cell
differentiation by bufalin, a potent Na+,K+-ATPase inhibitor
(M. Kurosawa et al.).
Inward rectifier
potassium channel Kir7.1 is highly expressed in the ion-transporting epithelial cells: Implication for a functional coupling with Na+,K+-ATPase
(N. Nakamura et al.).
Alteration of renal Na-K-ATPase in non-insulin dependent diabetes mellitus (NIDDM) model rats
(T. Satoh et al.).
Influence of Na/K ATPase pump and Ca2+ channel blockers on cytotoxicity of T-2 toxin
(M. Ghazi-Khanasari,
F. Shokri, M. Heidari).
2. Function and Regulatory Mechanism of Na/Cl Cotransporter
Reviews.
Na-K-Cl cotransporters in salt-sensitive
hypertension
(R.P. Garay, M. Alvarez-Guerra).
Regular articles.
Gene transcription of thiazide-sensitive Na-Cl cotransporter:
Effect of steroid hormones
(Y. Taniyama et al.).
Loss of functiion by a mutation in thiazide-sensitive Na-Cl cotransporter
gene found inGitelman's syndrome
(Y. Taniyama et al.).
3. Mechanism and Diseases of Phosphate Transport System.
Reviews.
Cellular/molecular mechanisms of renal and intestinal Na/Pi-cotransport
(J. Biber et al.).
Regular articles.
Pathophysiology
of X-linked hypophosphatemic rickets (XLH)
(E. Takeda et al.).
4. Molecular and Pharmacological Properties of Na/Ca-Exchanger.
Reviews.
Transcription control of the Na+/Ca2+ exchanger
(N. Gabellini, A. Zatti, E. Carafoli).
Na+/Ca2+
Exchanger: Molecular and pharmacological properties
(M. Shigekawa et al.).
Regulation and stoichiometry of Na+-Ca2+
exchange in inside-out macro patch excised from intact guinea-pig ventricular cells
(S. Matsuoka, Y. Fujioka, A. Noma).
Sodium-coupled
ion transporters and the macula densa cell Ca-signaling
(J. Peti-Peterdi, P.D. Bell).
Regular articles.
Amiodarone inhibits
Na+/Ca2+ exchange current in Guinea-pig ventricular cells
(Y. Watanabe, K. Mizuno, J. Kimura).
Signal cascade
of Na+/Ca2+ exchanger-involved delayed apoptosis of astrocytes
(K. Takuma, T. Matsuda, A. Baba).
Functional importance
of internal repeats in Na+/Ca2+ exchanger
(T. Iwamoto et al.).
Protein kinase C-dependent regulation
of Na+/Ca2+ exchanger
(T. Iwamoto et al.).
Functional coupling of Na+/Ca2+ exchanger
with Ca2+ release from intracellular stores in cultured cells from guinea pig ileum
(T. Hisamitsu et al.).
Osteoclastogenesis
and activation of Na+/Ca2+ exchanger isoform 1
(H. Amano et al.).
5. Role of Na/H Exchanger in Biological
Controls.
Reviews.
Short-term regulation of NHE3 by EGF and protein kinase C but not protein kinase A involves vesicle trafficking
in epithelial cells and fibroblasts
(M. Donowitz et al.).
Structure-function relationships of mammalian Na+/H+
exchangers. Regulatory mechanisms and role of the cytoskelton
J. Orlowski
Structure-function of the Na+/H+ exchanger:
A novel membrane topology model
(S. Wakabayashi et al.).
The cloned capsaicin receptor is a heat- and proton-activated ion
channel
(M. Tominaga, D. Julius).
Regular articles.
Regulation of Na+/H+ exchanger activity by hyperosmolality
in rat kidney inner medullary collecting duct cells
(N. Suzuki et al.).
Cell swelling-associated activation of a voltage gated
proton (H+) current in rat microglia
(H. Morihata et al.).
Maintenance of acid-base balance by Na+/H+
exchanger (NHE3) and Na+/HCO3
- cotransporter (NBC) in the gill of dace adapted to extremely acidic conditions
(pH 3.5)
(T. Hirata et al.).
Hyperosmolality increases expression of a Na+/H+ exchanger isoform NHE1,
but not NHE4 in cultured rat kidney inner medullary collecting duct cells
(N. Anzai et al.).
The role of acidic residues in
membrane-spanning regions of Na+/H+ antiporters from bacteria
(T. Nakamura et al.).
Na+ and
Li+ torelance of a freshwater cyanobacterium Synechococcus sp. PCC 7942 transformed with nhaAn gene from Vibrio alginolyticus
(N. Kaku et al.).
6. Physiological, Biochemical and Biophysical Aspects of Sodium Channel.
Reviews.
The molecular biology and function of H+-gated Na+ channels
(R. Waldmann et al.).
Structure,
function, and molecular pharmacology of voltage-gated sodium channels
(W.A. Catterall).
Dopamine, a modulator of sodium homeostasis
in peripheral tissue as well as in central nervous system
(U. Holtback et al.).
Novel members in the NaC/DEG family of sodium
channels
(E. Lingueglia et al.).
Structure of the voltage sensitive sodium channel
(C. Sato et al.).
Functions of
voltage sensitive ion channels of muscles and its relation to myotonia and periodic paralysis
(K. Terada, S. Yoshizawa, C. Nishimura).
Calmodulin is a Iigand for neuronal voltage-gated sodium channels
(N. Tricaud, G. Alcaraz, F. Couraud).
Induction of epithelial Na+
channel (ENaC) in rat ileum after proctocolectomy
(Y. Suzuki et al.).
Regular articles.
Inorganic cation inhibition
of sodium conductance in adult rat lung type II pheumocytes
(K.J. Kim et al.).
Neuroprotective agents, riluzole and NS-7, prevent
catecholamine release by reducing sodium influx in adrenal chromaffin cells
(H. Yokoo et al.).
Mitogen-activated protein kinase,
protein kinase C and cyclic AMP-dependent protein kinase differentially regulate the density of cell surface sodium channels
(T. Yanagita et al.).
Model analysis of the ion channel diseases of muscle
(K. Terada, S. Yoshidawa, C. Nishimura).
A novel class of Na+
and Ca2+ channel dual blockers with highly potent anti-ischemic effects
(H. Annoura et al.).
Molecular cloning of
a novel form (two repeat) protein related to voltage-gated sodium and calcium channels
(K. Ishibashi, M. Suzuki, M. Imai).
Biophysical
properties of ENaC associated with Liddle's disease expressed in Xenopus oocytes
(H.-L. Ji, C.M. Fuller, D.J. Benos).
Identify the
kinetic switch in abENaC
(S.J. Copeland et al.).
Mechanisms of cation permeation cardiac sodium channel: Description by dynamic
pore model
(Y. Kurata et al.).
Effect of cAMP on electrogenic Na+ absorption in rat distal colon
(Y. Suzuki, Y.
Tsuchiya).
7. Regulatory Mechanism of Ca Channel.
Reviews.
Role of inositol 1,4,5-triphosphate (IP3) gated calcium release
channel in cell function
(K. Mikoshiba).
Cloning and expression of the epithelial calcium channel, ECaC
(R.J.M. Bindels).
Feedback
regulation of the inositol 1,4,5-trisphosphate receptor/Ca2+ release channel by Ca2+
(T. Michikawa, K. Mikoshiba).
Receptor-activated Ca2+ influx: TRP Proteins and capacitative Ca2+ entry
(Y. Mori).
Regular articles.
ANP stimulates Ca2+ reabsorption in rabbit kidney via a cGMP-dependent mechanism
(J. Hoenderop et al.).
Association
pattern of the heterooligomer of inositol 1,4,5-trisphosphate receptors
(H. Tanaka et al.).
Dialysis of inositol 1,4,5-trisphosphate
and cADP-ribose induced inward currents and Ca2+ uptake in turtle olfactory sensory neurons
(K. Sekimoto, M. Kashiwayanagi).
Calcium channel blockade by NS-7, a neuroprotective compound, is dependent on channel activity
(M. Oka, Y. Itoh, Y. Ukai).
Effects
of myosin light chain kinase inhibitor on the function of osteoclast like cells
(K. Takagi et al.).
8. Functions and Biological
Aspects on Potassium Channel.
Reviews.
Membrane phospholipids influence potassium channel function
(K. Turnheim, J. Gruber, C.
Wachter).
Translocation of a calcium-permeable cation channel induced by insulin-like growth factor-1
(I. Kojima, M. Kanzaki).
Regular
articles.
Hypoxia-sensitive K+ channels in rat adrenal chromaffin cells
(N. Mochizuki-Oda, Y. Takeuchi, Y. Watanabe).
Regulation of ATP-dependent K+ channel in opossum kidney proximal tubule cells by phosphorylation and dephosphorylation processes
(M. Kubokawa et al.).
A novel type of ATP block on an IK channel
(M. Shindo, Y. Imai, Y. Sohma).
Changes in gene expression
of cardiac K+ channels in rat fetus
(N. Tohse et al.).
Expression of putative stretch activated nonselective cation
channels of mammal
(M. Suzuki, K. Ishibashi, M. Imai).
9. A Role of Chloride Channel and Its Related Proteins in Homeostasis of
Bio-organs.
Reviews.
Cell volume-sensitive Cl channel and ATP release
(Y. Okada et al.).
Immunolocalization of voltage-gated
chloride channels CLC3 and CLC5 in rat brain
(B. Jovov, D.J. Benos, L.L. McMahon).
Regular articles
Ca2+-activated Cl-channels:
A newly emerging anion transport family
(C.M. Fuller et al.).
Effect of extracellular Ca2+ on volume sensitivity
of the swelling-activated Cl - channel in epithelial cells
(T. Shimizu, S. Morishima, Y. Okada).
Co-operative action of hypotonic
stress and a rise in external Ca2+ on Cl currents of murine osteoclasts
(H. Sakai et al.).
Chloride secretion caused
by thermostable direct hemolysin of Vibrio parahaemolyticus
(A. Takahashi, K. Imura, T. Honda).
10. Biological Aspects on Water
Channels.
Regular articles.
Trafficking of AQP5 water channel in parotid glands by neurotransmitters
(Y. Ishikawa et al.).
Phloretin inhibits a regulatory volume decrease in human epithelial cells
(H-T. Fan et al.).
11. Fundamental and Applied
Studies on Transports of Peptides and the Other Organic Compounds.
Reviews.
Flounder renal transporters for p-aminohippurate
(fROAT) and dicarboxylates (fNaDC-3)
(G. Burckhardt et al.).
Peptide Transporter and its application for drug delivery
(K.
Inui, T. Tomohiro, H. Saito).
Molecular biology of multispecific organic anion transporter family (OAT family)
(T. Sekine, S.H. Cha,
H. Endou).
Is transport mechanism-based drug molecular design possible? Molecular design of biochemical probes targeting MRP1/GS-X pump
(T. Ishikawa, K. Furuta, M. Suzuki).
Structure, function and regulation of organic cation transporters
(H. Saito et al.).
Transporter-mediated drug delivery and targeting: What are the opportunities?
(A. Tsuji).
The family of amino acid transporters associated
with type II membrane glycoproteins:
The roles in epithelial transport and cellular nutrition
(Y. Kanai et al.).
Role of the
MRP family in the intestinal and hepatobiliary transport of xenobiotics
(H. Suzuki, Y. Sugiyama).
Regular articles.
The identification
of the bile acid binding site in the ileal lipid binding protein of the ileal Na+/bile acid cotransport system
(W. Kramer,
K. Sauber, S. Stengelin).
Substrate specificity and pharmacophore model of ileal and hepatic Na+/bile acid cotransporters
(W. Kramer, K.-H. Baringhaus, S. Stengelin).
Na+-dependent carnitine transport is mediated by multifunctional OCTN transporter
family
(I. Tamai et al.).
Hybrid motor with the H+- and Na+-driven components can rotate Vibro polar
flagella using sodium ion
(Y. Asai et al.).
Hypoxanthine transport and transient expression of possible regulatory proteins
in COS-1 cells
(D. Johnson, M. Shayeghi, S.M. Jarvis)
Molecular cloning and characterization of multispecific organic anion transporter
4, OAT4.
(S.H. Cha et al.).
Tubular localization and drug recognition of organic anion transporters OAT-K1 and OAT-K2
(S.
Masuda et al.).
Sigma receptor ligand-indueed up-regulation of H+/peptide transpor PEPT1 in the human intestinal
cell line Caco-2
(T. Fujita et al.).
Functional characteristics of brain peptide transporter in rat: Involvement of high
affinity type H+/peptide transporter PEPT2
(T. Fujita et al.).
Genomic structure, mutations and, functional role
of the canalicular multispecific organic anion transporter (MRp2/cMOAT) gene in Dubin-Johnson syndrome and cancer
(M. Wada et al.).
Epinephrine-induced transmural transport of benzylpenicillin in rat small intestine
(Y. Ishikawa et al.).
12. A Role
and Genetic Control of SGLTs in Glucose Metabolism.
Review.
Post-transcriptional regulation of Na+/glucose cotransporter
expression
(J. Lever et al.).
Regular articles.
Cloning and characterization of rat SGLT2 isoforms
(H. Murao et
al.).
Transportability and recognizability of SGLT1 for alkylglucosides: TRN (Transportable, recognizable, non-interactive) classification
of glucose conjugates
(T. Mizuma, S. Matsumoto, S. Awazu).
NGF-indueed glucose uptake into rat pheochromocytoma PC12 cells
(A. Satoh,
H. Harada, Y. Suketa).
Characterization of Na+/glucose cotransporter (SGLT1) from rat jejunum
(T. Yokoyama et al.).
Glucose transport activity in cultered renal epithelial cells is suppressed by angiotensin II
(K. Kawano, H. Murao, Y. Suketa).
13.
Molecular Biology on GABA Receptor and Other's.
Reviews.
Ionotropic GABA receptors: Ligand gated ion channels
(G.A.R. Johnston,
M. Chebib, R.K. Duke).
The neuronal GABA transporter GAT1 as a target for action of antiepileptic drugs
(U. Eckstein-Ludwig et
al.).
3. Glutamic acid decarboxylase and GABA transporter as GABAergic neuron markers
(K. Obata, Y. Yanagawa, K. Makinae).
Regular
articles.
Effects of GABA-uptake inhibitor and GABA-transaminase inhibitor in EL mice
(Y. Fueta et al.).
Potentiation
of GABAA receptors expressed in Xenopus oocytes by perfume and phytoncid
(H. Aoshima, K. Hamamoto).
Functional mapping
of L-DOPAergic systems in the CNS
(Y. Goshima et al.).
Alterations of glutamate and GABA responses by in vivo neuronal injury
(J. Nabekura et al.).
Imaging glutamate neurotransmission by laserphotolysis microscopy
(T. Sakurai et al.).
Scanning
laser microphotolysis system for analysis of the functional receptors in living neurons
(A. Watanabe et al.).
Cationic modulation
of 5-HT3 receptor response in Guinia-pig atrium sensory neuron
T. Watanabe, H. Nishio
TNF-α and dexamethasone suppress
L-DOPA transport in the blood-brain barrier (BBB)
(T. Kageyama, S. Shimohama).
A critical role of nicotinic Ach receptors in a pathway
of NMDA receptor-dependent LTP
(T. Nishizaki, S. Matsuyama).
14. A Role of Purinergic Receptors as Sensory and Regulatory Systems.
Regular articles.
Ionotropic P2X7 receptor-mediated cell death in rat glomerular mesangial cells
(K. Miyamoto et
al.).
Distinct responses to ATP of identified neurons in mesencephalic trigeminal nucleus and locus coeruleus in the rat pontin
slice
(F. Kato, M. Kawamura, E. Masaki).
Synergistic interaction of oxytocin and purinergic receptors on intracellular Ca2+
increase via inositol-phospholipid signalling pathways in mammary myoepithelial cells
(H. Nakano, K. Furuya, S. Yamagishi).
A2a adenosine
receptor facilitates hippocampal neurotransmission by blocking glutamate uptake via the glial glutamate transporter GLT-1
(T. Nishizaki,
S. Matsuyama).
15. Structure and Funcion of ABC and Related Proteins.
Reviews.
Cellular bases of the selective sensitive sensitivity
to energy deprivation and excitotoxicity in different neuronal subtypes
(D. Centonze et al.).
How do P-glycoprotein and other
ABC proteins reconginize their substrates?
(K. Ueda, Y. Taguchi).
Regular articles.
CF-TR-dependant and -independant ATP release
iuduced by osmotic swelling
(A. Hazama et al.).
ATP release by Ins(1,4,5 )P3-generating peptides from Guinea pig
taenia coli
(T. Katsuragi et al.).
Reconstitution of Na+-translocating NADH-quinone reductase complex from its
component subunits
(Y. Nakayama, M. Hayashi, T. Unemoto).
Barium contracture in rat ventricular slices and its energy expenditure: Inhibitory
effect of pretreatment with cyclopiazoic acid
(H. Kohzuki et al.).
Bibliographic & ordering Information
Hardbound, 460 pages, publication date: AUG-2000
ISBN-13: 978-0-444-82986-3
ISBN-10: 0-444-82986-5
Imprint: EXCERPTA MEDICA
Price: Order form
USD 155
GBP 103.50
EUR 155
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